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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Baumannia cicadellinicola subsp. Homalodisca coagulata
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciBCIC374463:GI6Q-20-MONOMER.
UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:BCI_0020
OrganismiBaumannia cicadellinicola subsp. Homalodisca coagulata
Taxonomic identifieri374463 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCandidatus Baumannia
Proteomesi
  • UP000002427 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821Glycerol-3-phosphate acyltransferasePRO_1000049428Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi374463.BCI_0020.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi310 – 3156HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LU65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNWRAIYNK ILYLLLKIVV RSHIIPPKLL AEICLDIQEP MMYVLPYNSK
60 70 80 90 100
CDLLTLRILC IQYQLPDPLK PIFIXGVRFP RYLFIDQSCH IRSDVTKQQQ
110 120 130 140 150
YGRILHNFIT LYRHNSCSNI QILPVWVMFG RCPGKESYKN KKTTSIQFFC
160 170 180 190 200
LLKKIINVIW LGRDSFIYFS PIGSIPISYI ANSNYTINSI MILKLFRLGR
210 220 230 240 250
IHFLRQKRIA IGPSLLVRKH LFEKLLASQT ITKLVEDEAR SKKISIKQAQ
260 270 280 290 300
QKALVIIEEI AADFSYETIR LSDRVLSWIW NMLYQGLYVC NADRVRKLAE
310 320 330 340 350
KGHEIIYLPC HRSHMDYLLL SYILYHEGLV IPYIAAGINL NFWPAGQIFR
360 370 380 390 400
KLGAFFIHRT FKGHQKLYSA IFREYLYQLF NGGYSVAYFL EGSRSRTGRL
410 420 430 440 450
QAPKTGTLTI TIQSMLHLGK KKPIILVPVY ISYEHVIEVA SYTKELYGVV
460 470 480 490 500
KKKEGLIHMI SGLRNLRNLG RGYINFGEPL PLLTWLNQQV PQWQDDINSI
510 520 530 540 550
EGNRPNWLAL TVDYLAVTIM TRINNAVAVN AMNLCSSIIL ASRQYSCSSI
560 570 580 590 600
VITRTRLLSQ LKCYLELLRN VPYDAEVTVP NVTPEDLFQH LITLNQFTIK
610 620 630 640 650
NNSIIYVSSE KTALITYYRN NIQHLFILPS LLAIIIIAQP GISRKLIHQK
660 670 680 690 700
LLSLYPLLKV ELFMRFSYQE LPHVIDLMIT ELHRQDILYE QQTKIYPVPK
710 720 730 740 750
RMDELQLLAA SGGRETLYRY AITFSLLCSY TRINRYSLEK QSIIIAQHLS
760 770 780 790 800
KIHSIYALEF IDKTIFSTLI TTLRHEGYLS DSGEIHASQA KEIYKFLSAL
810 820
ISPEIQTSIT NALYHIKTVV N
Length:821
Mass (Da):95,185
Last modified:May 30, 2006 - v1
Checksum:i64771BE4E3CE7524
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000238 Genomic DNA. Translation: ABF13834.1.
RefSeqiWP_011520232.1. NC_007984.1.

Genome annotation databases

EnsemblBacteriaiABF13834; ABF13834; BCI_0020.
KEGGibci:BCI_0020.
PATRICi21073527. VBIBauCic75062_0020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000238 Genomic DNA. Translation: ABF13834.1.
RefSeqiWP_011520232.1. NC_007984.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi374463.BCI_0020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF13834; ABF13834; BCI_0020.
KEGGibci:BCI_0020.
PATRICi21073527. VBIBauCic75062_0020.

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.
BioCyciBCIC374463:GI6Q-20-MONOMER.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_BAUCH
AccessioniPrimary (citable) accession number: Q1LU65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.