Reviewed, UniProtKB/Swiss-Prot Q1LU62 (AROB_BAUCH)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BCI_0023

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm By similarity HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094462

Sequences

	Sequence		Length	Mass (Da)
	Q1LU62-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 1060A952ABBC8746	FASTA	359	39,636
	10 20 30 40 50 60 MDRISITLGE RSYAIIIANG LLQDPTSFWP LARGDKVLVV TSNYIASLYL EILSQILTEL 70 80 90 100 110 120 GIIIDLCILP DGEQYKSLAM IDKIFTALLK KYHNNDTTII AFGGGVIGDL AGFAAANYLR 130 140 150 160 170 180 GVRIIQIPTT LLSQVDSSVG GKTAVNHPLG KNMIGTIYQP TSVIIDPNCL ATLPRRELSS 190 200 210 220 230 240 GLAEVIKYGI LFDVNFFNWL ELNIDALLGL EPHTVTWCIR RCCEIKAKIV TADEHEKGVR 250 260 270 280 290 300 TLLNLGHTYG HAIETHMGYG NWLHGEAVAV GIMIVVQVSC SLGYFSNVDT ERVKTLLLRA 310 320 330 340 350 GLPVIGPMKI SLEDYLPYIM RDKKTTNGIL HIILPLKLGS AEVHTYRISE WQKLIAHLI

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000238 Genomic DNA. Translation: ABF14084.1.
RefSeq	YP_588502.1.
3D structure databases
SMR	Q1LU62. Positions 3-342.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LU62.
Genome annotation databases
GeneID	4056233.
GenomeReviews	Gene locus BCI_0023 in contig CP000238_GR.
KEGG	bci:BCI_0023.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0337.
HOGENOM	HBG632303.
OMA	APESMDF.
PhylomeDB	Q1LU62.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BAUCH

Accession

Primary (citable) accession number: Q1LU62

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 30, 2006
Last modified:	February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)