Q1LU61 (AROK_BAUCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate kinase
Short name=SK
EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	BCI_0024

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP MF_00109
Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00109
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109
Subunit structure	Monomer By similarity. HAMAP MF_00109
Subcellular location	Cytoplasm Probable HAMAP MF_00109.
Sequence similarities	Belongs to the shikimate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW shikimate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 173	173	Shikimate kinase HAMAP MF_00109		PRO_1000022965
Regions
	Nucleotide binding	14 – 19	6	ATP By similarity
Sites
	Metal binding	18	1	Magnesium By similarity
	Binding site	36	1	Substrate By similarity
	Binding site	60	1	Substrate By similarity
	Binding site	82	1	Substrate; via amide nitrogen By similarity
	Binding site	120	1	ATP By similarity
	Binding site	140	1	Substrate By similarity
	Binding site	157	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1LU61 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 4014D170B467B0AC	FASTA	173	19,629
	10 20 30 40 50 60 MVEKRNIFLI GPMGAGKSTI GRQLAQQLNM EFFDSDQEIE RLTGADIGWV FDVEGEDGFR 70 80 90 100 110 120 SREEKVINEL TEKQGIVLAT GGGSIKSRET RNRLSARGVV IYLDTTIEKQ LVRTKRDKKR 130 140 150 160 170 PLLQAKIPSR EVLEALARER NPLYEEIADI TIRANEQSAK VVAYHIISML ERN

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000238 Genomic DNA. Translation: ABF14048.1.
RefSeq	YP_588503.1. NC_007984.1.
3D structure databases
ProteinModelPortal	Q1LU61.
SMR	Q1LU61. Positions 3-171.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LU61.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4056421.
GenomeReviews	Gene locus BCI_0024 in contig CP000238_GR.
KEGG	bci:BCI_0024.
PATRIC	21073535. VBIBauCic75062_0024.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0703.
HOGENOM	HBG335815.
OMA	MSISAFF.
PhylomeDB	Q1LU61.
ProtClustDB	PRK05057.
Enzyme and pathway databases
BioCyc	BCIC186490:BCI_0024-MONOMER.
Family and domain databases
HAMAP	MF_00109. Shikimate_kinase. [Tree]
InterPro	IPR000623. Shikimate_kinase. IPR023000. Shikimate_kinase_CS. [Graphical view]
KO	K00891.
Pfam	PF01202. SKI. 1 hit. [Graphical view]
PRINTS	PR01100. SHIKIMTKNASE.
PROSITE	PS01128. SHIKIMATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_BAUCH

Accession

Primary (citable) accession number: Q1LU61

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 30, 2006
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program