Reviewed, UniProtKB/Swiss-Prot Q1LU51 (PUR9_BAUCH)

Names and origin

Protein names

Recommended name:
    Bifunctional purine biosynthesis protein purH
Including the following 2 domains:
    1- Recommended name:
            Phosphoribosylaminoimidazolecarboxamide formyltransferase
              EC=2.1.2.3
        Alternative name(s):
            AICAR transformylase
    2- Recommended name:
            IMP cyclohydrolase
              EC=3.5.4.10
        Alternative name(s):
            Inosinicase
            IMP synthetase
            ATIC

Gene names

Name:	purH
Ordered Locus Names:	BCI_0035

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP MF_00139 Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.
Domain	The IMP cyclohydrolase activity resides in the N-terminal region By similarity.
Sequence similarities	Belongs to the purH family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Hydrolase Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	IMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP phosphoribosylaminoimidazolecarboxamide formyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Bifunctional purine biosynthesis protein purH HAMAP MF_00139		PRO_1000018847

Sequences

	Sequence		Length	Mass (Da)
	Q1LU51-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 4A77AA22AA874B48	FASTA	526	58,384
	10 20 30 40 50 60 MQRPIIIRRA LLSVSDKTNI CELAKSLLKR GVQLISTNGT ARLLVNAGIH VTEVSNYTGF 70 80 90 100 110 120 PEIMDGRVKT LHPKIHGGIL ARRNIDDTIM QQYKIEHIDM VVVNLYPFAE VVASATCNHE 130 140 150 160 170 180 KVVENIDIGG TALLRSAAKN YSNVVVVVSI NDYISIINEI DCNNGAVSLE TRLNLAIKAF 190 200 210 220 230 240 QHTATYDSQI KDYFTSQVYT DSSKCSSIFP PILNINFVKK QDMRYGENQH QLAAFYLDTR 250 260 270 280 290 300 NKEKSIATTK QLQGRALSYN NIADADAALE CVKEFSEPAC VIVKHINPCS VAMGKTILVA 310 320 330 340 350 360 YQRAYETDPT SAFGGVIAFN RSLDLCTAQE IIARQFIEVI IAPTVDQEAL LILAKKKNIR 370 380 390 400 410 420 VLSSGQWNKP IPNLNFRQVN GGLLVQERDL VMINLHDLRI VSQRQPTTME IQDALFCWKV 430 440 450 460 470 480 VKFVKSNAIV YARNQRTIGI GAGQMSRIDS AKIASIKAID NKLNIRGSTM ASDAFFPFRD 490 500 510 520 GLDSAAKVGV SCVIQPGGSI RDQEVITAAN EHNIAMIFTN IRHFRH

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000238 Genomic DNA. Translation: ABF13814.1.
RefSeq	YP_588513.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4056143.
GenomeReviews	Gene locus BCI_0035 in contig CP000238_GR.
KEGG	bci:BCI_0035.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1LU51.
OMA	Q1LU51. VVKHVKS.
Family and domain databases
HAMAP	MF_00139. [Tree]
InterPro	IPR002695. AICARFT_IMPCHas. IPR013982. AICARFT_IMPCHas_formly. IPR011607. MGS. [Graphical view]
PANTHER	PTHR11692. AICARFT_IMPCHas. 1 hit.
Pfam	PF01808. AICARFT_IMPCHas. 1 hit. PF02142. MGS. 1 hit. [Graphical view]
PIRSF	PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMART	SM00798. AICARFT_IMPCHas. 1 hit. [Graphical view]
TIGRFAMs	TIGR00355. purH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR9_BAUCH

Accession

Primary (citable) accession number: Q1LU51

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 30, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)