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Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Baumannia cicadellinicola subsp. Homalodisca coagulata
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotation

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

Cofactori

dipyrromethaneUniRule annotationNote: Binds 1 dipyrromethane group covalently.UniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Porphobilinogen deaminase (hemC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPorphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
Short name:
PBGUniRule annotation
Alternative name(s):
Hydroxymethylbilane synthaseUniRule annotation
Short name:
HMBSUniRule annotation
Pre-uroporphyrinogen synthaseUniRule annotation
Gene namesi
Name:hemCUniRule annotation
Ordered Locus Names:BCI_0061
OrganismiBaumannia cicadellinicola subsp. Homalodisca coagulata
Taxonomic identifieri374463 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCandidatus Baumannia
Proteomesi
  • UP000002427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003042141 – 311Porphobilinogen deaminaseAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei242S-(dipyrrolylmethanemethyl)cysteineUniRule annotation1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi374463.BCI_0061.

Structurei

3D structure databases

ProteinModelPortaliQ1LU25.
SMRiQ1LU25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D6W. Bacteria.
COG0181. LUCA.
HOGENOMiHOG000228587.
KOiK01749.
OMAiCQVPIGV.
OrthoDBiPOG091H064B.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam. 1 hit.
InterProiView protein in InterPro
IPR000860. HemC.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiView protein in Pfam
PF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiView protein in PROSITE
PS00533. PORPHOBILINOGEN_DEAM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LU25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNNILKIAT RQSPLAIWQA NYVRNQLLSF YPTLLIELVP IVTSGDLILD
60 70 80 90 100
KPLMKAGGKR LFIKELEQAM LERRADIAVH SMKDITISFP EGIGLAVLCA
110 120 130 140 150
REDPRDAFIS THYASIDLLP TGAVVGTSSM RRQCQLRERR PDLVMRDLRG
160 170 180 190 200
NIGTRLEKLD KGEYDALILA AAGLKRLDLA HRIRMIIDPT ELLPAVGQGV
210 220 230 240 250
IGIEYRLEDT HILSILAPLH HSATALRVSA ERAMNAKLAG GCQVPIGSYA
260 270 280 290 300
EIEGDQIWLR ALVGSPDGSL IIRSEGRAPL SQAEILGQSI ANDLLYRGAE
310
SILCRAFQVD S
Length:311
Mass (Da):34,190
Last modified:May 30, 2006 - v1
Checksum:iC776496CBF9DC914
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000238 Genomic DNA. Translation: ABF14184.1.
RefSeqiWP_011520272.1. NC_007984.1.

Genome annotation databases

EnsemblBacteriaiABF14184; ABF14184; BCI_0061.
KEGGibci:BCI_0061.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000238 Genomic DNA. Translation: ABF14184.1.
RefSeqiWP_011520272.1. NC_007984.1.

3D structure databases

ProteinModelPortaliQ1LU25.
SMRiQ1LU25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi374463.BCI_0061.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF14184; ABF14184; BCI_0061.
KEGGibci:BCI_0061.

Phylogenomic databases

eggNOGiENOG4105D6W. Bacteria.
COG0181. LUCA.
HOGENOMiHOG000228587.
KOiK01749.
OMAiCQVPIGV.
OrthoDBiPOG091H064B.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00319.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam. 1 hit.
InterProiView protein in InterPro
IPR000860. HemC.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiView protein in Pfam
PF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiView protein in PROSITE
PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHEM3_BAUCH
AccessioniPrimary (citable) accession number: Q1LU25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 30, 2006
Last modified: June 7, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.