Reviewed, UniProtKB/Swiss-Prot Q1LTQ6 (GSH1_BAUCH)

Names and origin

Protein names

Recommended name:
    Glutamate--cysteine ligase
    EC=6.3.2.2
Alternative name(s):
    Gamma-glutamylcysteine synthetase
    Gamma-ECS
      Short name=GCS

Gene names

Name:	gshA
Ordered Locus Names:	BCI_0201

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. HAMAP MF_00578
Pathway	Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. HAMAP MF_00578
Sequence similarities	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Glutathione biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glutathione biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glutamate-cysteine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 523	523	Glutamate--cysteine ligase HAMAP MF_00578		PRO_1000025168

Sequences

	Sequence		Length	Mass (Da)
	Q1LTQ6-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: B91B940CE326C55B	FASTA	523	60,200
	10 20 30 40 50 60 MIPDVSSDTL FWLKANPQAL QGIYRGVERE TLRINTQGHL AQTPHPKKLG AALTHKWITT 70 80 90 100 110 120 DFAETLLEFI TPVAQDIDHM LTLLRDIHRH VARHLCNEWM WPMSMPCFID SQQQIKLAQY 130 140 150 160 170 180 GPSNMGRMKT LYRKGLKNRY SAMMQIISGV HYNFSLPLTF WQVYAGVSDM NSNKDIISAG 190 200 210 220 230 240 YLGLIRNYYR FGWIIPYIFG ASPGVCQSFM KNRDTDLPFI KASSGFLYLP YATSLRMSDL 250 260 270 280 290 300 GYANKSQSQL DITFNSLKEY VFRLKHAIRT PYADYQRIGL KKNGSYLQLN TNILQSENEL 310 320 330 340 350 360 YAPIRPKRIT KNEESPLDAL LRRGIEYIEV RALDINPFSP VGIDEEQVRF LDLFLIWCTL 370 380 390 400 410 420 APAPKMSTRE LLYTRLNWTK VILEGRKPGL TLIVDGGSSK KPLATIGKEL FSAMQALAET 430 440 450 460 470 480 LDSHNGNIQY QQVCHKLRAC IDQPELTLSA RILKEMKKYG IRGLGLTLAN QYFQILLEEP 490 500 510 520 LEMFNELTFD KEQIRSWHRQ LELEALDILS FDDFLAHINS HQQ

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000238 Genomic DNA. Translation: ABF13792.1.
RefSeq	YP_588658.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4056732.
GenomeReviews	Gene locus BCI_0201 in contig CP000238_GR.
KEGG	bci:BCI_0201.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1LTQ6.
OMA	Q1LTQ6. EYIEVRA.
Family and domain databases
HAMAP	MF_00578. [Tree]
InterPro	IPR007370. Glu_cys_ligase. IPR006334. Glut_cys_ligase. [Graphical view]
Pfam	PF04262. Glu_cys_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01434. glu_cys_ligase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GSH1_BAUCH

Accession

Primary (citable) accession number: Q1LTQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 30, 2006
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)