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Q1LTM9

- SYL_BAUCH

UniProt

Q1LTM9 - SYL_BAUCH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Baumannia cicadellinicola subsp. Homalodisca coagulata
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei623 – 6231ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBCIC374463:GI6Q-232-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BCI_0232
    OrganismiBaumannia cicadellinicola subsp. Homalodisca coagulata
    Taxonomic identifieri374463 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCandidatus Baumannia
    ProteomesiUP000002427: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 861861Leucine--tRNA ligasePRO_1000009296Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi374463.BCI_0232.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1LTM9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi620 – 6245"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1LTM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEFYDPKNI ESTIQQYWHE NNTFTVTEDF SKEKYYCLSM LPYPSGNLHM    50
    GHVRNYTIGD VLSRYHRMLG KNVMQPIGWD AFGLPAERAA LKNQTAPATW 100
    TYANIETMKK QLKQLGFSYD WSREITTCRP EYYRWEQWFF IQLYEKGLVY 150
    KKTSFVNWCS NDQTVLANEQ VIDGCCWRCG APIMLKDIPQ WFLKITAYAD 200
    QLLHDLDKLD GWPEQIKNMQ RNWIGRSEGI NITFQVIDMK ETLTIYTTRP 250
    DTLMGVTYLS IAINHHLAQQ AANNNRLLSD FIEHSRPTKL SEAEIVKVNR 300
    VKTGIFTGLY AIHPLTEEKL PIWVTNFVLM DYGTGAIMAV PGHDQRDWDF 350
    ARQYNLPVKN IIRNIDGSKP TISGIIPEGI LYNSGEFNGL RSLEASKIIT 400
    DILVARGIGE TKVNYRLRDW VISRQRYWGT PIPMMTLEDG TVVPTPVDQL 450
    PVILPEYLLI NSISNPLKDD HLWMKTNYNN NIATRETDTF DTFMESSWYY 500
    ARYTCPNYDQ GMLDTTAANY WLPIDQYIGG IEHAIMHLMY FRFYHKLLRD 550
    AGMLTSDEPT IRILCQGMVL ADSFYYISCT TGERIWVSPI NVRVQRDEKG 600
    NIINAIDLQG HHLVYAGTIK MSKSKNNSID PLTMVEKYGA DTIRLFIMFA 650
    SPVTMALEWR ESGVEGANRF LKRLWKLTYD HIQRGKVIKL DLAAMSNDNK 700
    ILRRELHQTI AKVTDDISRR YAFNTAIAAL MEITNKLMHA SYHSQQDRAI 750
    VQEALLAVVR MLYPFTPHLC FKLWQALNGE GDIDNAPWPI VDQLALVEDT 800
    NLIVIQINGR FRSKIIVPVS ADKALIIERA SKEKLVAKYL EGTKVQKIIY 850
    VPGKLLNLVL K 861
    Length:861
    Mass (Da):99,335
    Last modified:May 30, 2006 - v1
    Checksum:i151E545728E934B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000238 Genomic DNA. Translation: ABF13994.1.
    RefSeqiWP_011520418.1. NC_007984.1.
    YP_588685.1. NC_007984.1.

    Genome annotation databases

    EnsemblBacteriaiABF13994; ABF13994; BCI_0232.
    GeneIDi4056741.
    KEGGibci:BCI_0232.
    PATRICi21073965. VBIBauCic75062_0221.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000238 Genomic DNA. Translation: ABF13994.1 .
    RefSeqi WP_011520418.1. NC_007984.1.
    YP_588685.1. NC_007984.1.

    3D structure databases

    ProteinModelPortali Q1LTM9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374463.BCI_0232.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF13994 ; ABF13994 ; BCI_0232 .
    GeneIDi 4056741.
    KEGGi bci:BCI_0232.
    PATRICi 21073965. VBIBauCic75062_0221.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BCIC374463:GI6Q-232-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters."
      Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A.
      PLoS Biol. 4:1079-1092(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSYL_BAUCH
    AccessioniPrimary (citable) accession number: Q1LTM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3