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Q1LTM9 (SYL_BAUCH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:BCI_0232
OrganismBaumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]
Taxonomic identifier374463 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaCandidatus Baumannia

Protein attributes

Sequence length861 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 861861Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009296

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif620 – 6245"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6231ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1LTM9 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 151E545728E934B5

FASTA86199,335
        10         20         30         40         50         60 
MQEFYDPKNI ESTIQQYWHE NNTFTVTEDF SKEKYYCLSM LPYPSGNLHM GHVRNYTIGD 

        70         80         90        100        110        120 
VLSRYHRMLG KNVMQPIGWD AFGLPAERAA LKNQTAPATW TYANIETMKK QLKQLGFSYD 

       130        140        150        160        170        180 
WSREITTCRP EYYRWEQWFF IQLYEKGLVY KKTSFVNWCS NDQTVLANEQ VIDGCCWRCG 

       190        200        210        220        230        240 
APIMLKDIPQ WFLKITAYAD QLLHDLDKLD GWPEQIKNMQ RNWIGRSEGI NITFQVIDMK 

       250        260        270        280        290        300 
ETLTIYTTRP DTLMGVTYLS IAINHHLAQQ AANNNRLLSD FIEHSRPTKL SEAEIVKVNR 

       310        320        330        340        350        360 
VKTGIFTGLY AIHPLTEEKL PIWVTNFVLM DYGTGAIMAV PGHDQRDWDF ARQYNLPVKN 

       370        380        390        400        410        420 
IIRNIDGSKP TISGIIPEGI LYNSGEFNGL RSLEASKIIT DILVARGIGE TKVNYRLRDW 

       430        440        450        460        470        480 
VISRQRYWGT PIPMMTLEDG TVVPTPVDQL PVILPEYLLI NSISNPLKDD HLWMKTNYNN 

       490        500        510        520        530        540 
NIATRETDTF DTFMESSWYY ARYTCPNYDQ GMLDTTAANY WLPIDQYIGG IEHAIMHLMY 

       550        560        570        580        590        600 
FRFYHKLLRD AGMLTSDEPT IRILCQGMVL ADSFYYISCT TGERIWVSPI NVRVQRDEKG 

       610        620        630        640        650        660 
NIINAIDLQG HHLVYAGTIK MSKSKNNSID PLTMVEKYGA DTIRLFIMFA SPVTMALEWR 

       670        680        690        700        710        720 
ESGVEGANRF LKRLWKLTYD HIQRGKVIKL DLAAMSNDNK ILRRELHQTI AKVTDDISRR 

       730        740        750        760        770        780 
YAFNTAIAAL MEITNKLMHA SYHSQQDRAI VQEALLAVVR MLYPFTPHLC FKLWQALNGE 

       790        800        810        820        830        840 
GDIDNAPWPI VDQLALVEDT NLIVIQINGR FRSKIIVPVS ADKALIIERA SKEKLVAKYL 

       850        860 
EGTKVQKIIY VPGKLLNLVL K 

« Hide

References

[1]"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters."
Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A.
PLoS Biol. 4:1079-1092(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000238 Genomic DNA. Translation: ABF13994.1.
RefSeqYP_588685.1. NC_007984.1.

3D structure databases

ProteinModelPortalQ1LTM9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING374463.BCI_0232.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF13994; ABF13994; BCI_0232.
GeneID4056741.
KEGGbci:BCI_0232.
PATRIC21073965. VBIBauCic75062_0221.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycBCIC374463:GI6Q-232-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_BAUCH
AccessionPrimary (citable) accession number: Q1LTM9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries