ID   BIOD_BAUCH              Reviewed;         225 AA.
AC   Q1LTL5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Dethiobiotin synthetase;
DE            EC=6.3.3.3;
DE   AltName: Full=Dethiobiotin synthase;
DE   AltName: Full=DTB synthetase;
DE            Short=DTBS;
GN   Name=bioD; OrderedLocusNames=BCI_0249;
OS   Baumannia cicadellinicola subsp. Homalodisca coagulata.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Candidatus Baumannia.
OX   NCBI_TaxID=374463;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16729848; DOI=10.1371/journal.pbio.0040188;
RA   Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L.,
RA   Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L.,
RA   Moran N.A., Eisen J.A.;
RT   "Metabolic complementarity and genomics of the dual bacterial
RT   symbiosis of sharpshooters.";
RL   PLoS Biol. 4:1079-1092(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + 7,8-diaminononanoate + CO(2) = ADP +
CC       phosphate + dethiobiotin.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis; biotin from
CC       6-carboxyhexanoyl-CoA: step 3/4.
CC   -!- SIMILARITY: Belongs to the dethiobiotin synthetase family.
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DR   EMBL; CP000238; ABF13909.1; -; Genomic_DNA.
DR   RefSeq; YP_588699.1; -.
DR   GeneID; 4056355; -.
DR   GenomeReviews; CP000238_GR; BCI_0249.
DR   KEGG; bci:BCI_0249; -.
DR   HOGENOM; Q1LTL5; -.
DR   OMA; Q1LTL5; CLIEGAG.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0042242; F:cobyrinic acid a,c-diamide synthase activity; IEA:InterPro.
DR   GO; GO:0004141; F:dethiobiotin synthase activity; IEA:HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:HAMAP.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00336; -; 1.
DR   InterPro; IPR004472; BioD_synth.
DR   InterPro; IPR002586; CbiA_P_synth.
DR   Pfam; PF01656; CbiA; 1.
DR   PIRSF; PIRSF006755; DTB_synth; 1.
DR   TIGRFAMs; TIGR00347; bioD; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Biotin biosynthesis; Complete proteome; Ligase;
KW   Magnesium; Nucleotide-binding.
FT   CHAIN         1    225       Dethiobiotin synthetase.
FT                                /FTId=PRO_0000302481.
FT   NP_BIND       9     17       ATP (By similarity).
SQ   SEQUENCE   225 AA;  24497 MW;  C3D348060C0BBE18 CRC64;
     MTKRYFITGT DTNVGKTLAA CALLQAAISI GYHAAGYKPV ATGYQLTLDG PRNNDALALL
     SNSNVILSYS QVNPLVFSEP TSPHIACRAE GRNIELSELS AGLKVIEQKS DWIVVEGAGG
     WFTPLGEGIL YSDWVNYEKL PVILVIGMKL GCINHALLTA LAIRQFGLQL VGWIANHIQP
     TTTWSQHYLA ELRNRLDAPL IGDIPWLSNI PVALLAKYIN LAELS
//