ID   PYRB_BAUCH              Reviewed;         311 AA.
AC   Q1LTK6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-MAR-2009, entry version 26.
DE   RecName: Full=Aspartate carbamoyltransferase;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase;
DE            Short=ATCase;
GN   Name=pyrB; OrderedLocusNames=BCI_0258;
OS   Baumannia cicadellinicola subsp. Homalodisca coagulata.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Candidatus Baumannia.
OX   NCBI_TaxID=374463;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16729848; DOI=10.1371/journal.pbio.0040188;
RA   Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L.,
RA   Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L.,
RA   Moran N.A., Eisen J.A.;
RT   "Metabolic complementarity and genomics of the dual bacterial
RT   symbiosis of sharpshooters.";
RL   PLoS Biol. 4:1079-1092(2006).
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; CP000238; ABF14189.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_588708.1; -.
DR   SMR; Q1LTK6; 33-339.
DR   GeneID; 4056548; -.
DR   GenomeReviews; CP000238_GR; BCI_0258.
DR   KEGG; bci:BCI_0258; -.
DR   HOGENOM; Q1LTK6; -.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    311       Aspartate carbamoyltransferase.
FT                                /FTId=PRO_0000321074.
SQ   SEQUENCE   311 AA;  35151 MW;  F8FF4EE5B73DE18A CRC64;
     MINPLYRKHI ISINDMSSNE LELVLNIAAH LKFKPQPELL KNKVIASCFF EASTRTRLSF
     ETAIHRLGAS VVGFSDAHST SLSKKGETLA DTISVISTYV DAIIIRHPHE GAARLATEFS
     GTVPILNAGD GANQHPTQTL LDLFNIYETQ GKLNNLRIAM VGDLKYGRTV HSLTQALIKF
     DSNHFYFIAP DTLGMPSYIL HTLIDHDIKY SMHLNLAEVI PELDILYMTR VQKERLDPTE
     YINVKAQFVL QIHHLLHARA NMRILHPLPR VDEIAYEVDQ TPYAYYFQQA GNGVFTRQAL
     LALVLNKYLT E
//