Q1LTK6 (PYRB_BAUCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BCI_0258

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.
Sequence caution	The sequence ABF14189.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321074

Sequences

	Sequence		Length	Mass (Da)
	Q1LTK6 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: F8FF4EE5B73DE18A	FASTA	311	35,151
	10 20 30 40 50 60 MINPLYRKHI ISINDMSSNE LELVLNIAAH LKFKPQPELL KNKVIASCFF EASTRTRLSF 70 80 90 100 110 120 ETAIHRLGAS VVGFSDAHST SLSKKGETLA DTISVISTYV DAIIIRHPHE GAARLATEFS 130 140 150 160 170 180 GTVPILNAGD GANQHPTQTL LDLFNIYETQ GKLNNLRIAM VGDLKYGRTV HSLTQALIKF 190 200 210 220 230 240 DSNHFYFIAP DTLGMPSYIL HTLIDHDIKY SMHLNLAEVI PELDILYMTR VQKERLDPTE 250 260 270 280 290 300 YINVKAQFVL QIHHLLHARA NMRILHPLPR VDEIAYEVDQ TPYAYYFQQA GNGVFTRQAL 310 LALVLNKYLT E

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000238 Genomic DNA. Translation: ABF14189.1. Different initiation.
RefSeq	YP_588708.1. NC_007984.1.
3D structure databases
ProteinModelPortal	Q1LTK6.
SMR	Q1LTK6. Positions 3-309.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LTK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4056548.
GenomeReviews	Gene locus BCI_0258 in contig CP000238_GR.
KEGG	bci:BCI_0258.
PATRIC	21074017. VBIBauCic75062_0244.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
Enzyme and pathway databases
BioCyc	BCIC186490:BCI_0258-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BAUCH

Accession

Primary (citable) accession number: Q1LTK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program