Q1LTI9 (DXS_BAUCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	BCI_0275

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	623 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 623	623	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000256382

Sequences

	Sequence		Length	Mass (Da)
	Q1LTI9 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: DF9007B00050FAD0	FASTA	623	68,720
	10 20 30 40 50 60 MSMQIKRYPT LDLADNPIKL RLLPKESLLT LCDELRQFLL TSVSGSSGHF ASGLGTVELT 70 80 90 100 110 120 VALHYVYNTP FDNVIWDVGH QAYPHKILTG RRECIATIRQ RNGLHPFPWR EESEYDILSV 130 140 150 160 170 180 GHSSTSISAG LGMAVAATYE GIGRKTVCVI GDGAMTAGMA FEALNHAGDI KSDLLVILND 190 200 210 220 230 240 NKMSISRNVG ALNNHLAQIL SGKLYLRINE SSKKALHGMP YLKELAKRTK EQIKNIIVPN 250 260 270 280 290 300 CTLFEELGFN YIGPVDGHDV QGMVHILKNM RCMKGPQLLH IITQKGRGYA PAEKDPTTWH 310 320 330 340 350 360 AVPKFDPAIG QLPYQNISNY PTYSDVFGDW LCNAATSNKK LIAITPAMRE GSGMAKFANQ 370 380 390 400 410 420 FPQQYFDVAI AEQHAVTFAA GLAISGYKPV VAIYSTFLQR AYDQVIHDVA IQKLPVLFAI 430 440 450 460 470 480 DRGGVVGADG QTHQGAFDLS YLRCVPNMVI MTPSDENECR LMLHTGYHYN NGPSAVRYPR 490 500 510 520 530 540 GNGIGVEYSL LRILPLGKAI VCRQGTKIAI LNFGTLLTQA KKVAKTFDAT LVDMRFVKPL 550 560 570 580 590 600 DIELINQLAI SHQALVTLEE NAVIGGAGSG VNEYLMRQRL LVPVLNIGLP DYFIPQGSQE 610 620 EIRAELKLDS DGIMEQIKQW LAR

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000238 Genomic DNA. Translation: ABF13902.1.
RefSeq	YP_588725.1. NC_007984.1.
3D structure databases
ProteinModelPortal	Q1LTI9.
SMR	Q1LTI9. Positions 4-622.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LTI9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4056487.
GenomeReviews	Gene locus BCI_0275 in contig CP000238_GR.
KEGG	bci:BCI_0275.
PATRIC	21074053. VBIBauCic75062_0262.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	EAMNAHA.
PhylomeDB	Q1LTI9.
Enzyme and pathway databases
BioCyc	BCIC186490:BCI_0275-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR001017. DH_E1. IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_BAUCH

Accession

Primary (citable) accession number: Q1LTI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	May 30, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program