Q1LTH2 (KPRS_BAUCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose-phosphate pyrophosphokinase
Short name=RPPK
EC=2.7.6.1

Alternative name(s):
Phosphoribosyl pyrophosphate synthase
Short name=P-Rib-PP synthase
Short name=PRPP synthase

Gene names

Name:	prs
Ordered Locus Names:	BCI_0293

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00583_B
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00583_B.
Sequence similarities	Belongs to the ribose-phosphate pyrophosphokinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: InterPro ribose phosphate diphosphokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Ribose-phosphate pyrophosphokinase HAMAP MF_00583_B		PRO_1000061199
Regions
	Region	210 – 223	14	Binding of phosphoribosylpyrophosphate Potential
Sites
	Metal binding	126	1	Magnesium Potential
	Metal binding	128	1	Magnesium Potential
	Metal binding	137	1	Magnesium Potential
	Metal binding	141	1	Magnesium Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1LTH2 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: C5FFFC9C36ACC173	FASTA	312	34,089
	10 20 30 40 50 60 MKLFAGNAIP ELAQLIANRL YTSLGVAAVN RFSDGEISVQ INENVRGGDL FIIQSTCAPT 70 80 90 100 110 120 NDNLMELVVM VDALRRASAG RITAVMPYFG YSRQDRRVRS ARVPITAKVV ADFLSSVGVD 130 140 150 160 170 180 RVLTVDLHAE QIQGFFDVPV DNVFGSPILL EDMLQQDFNN PIVVSPDIGG VVRARAIAKL 190 200 210 220 230 240 LNDTDMAIID KRRPRANMSQ VMHIIGEVAD RDCVLVDDMI DTSSTLCKAA EALKEHGAKR 250 260 270 280 290 300 VFAYATHPIF SGQAHANIKN SVIDEVIICD TIPLNSAIKA LPNVRTLTLS GMLAEAIRRI 310 SNEESISAMF EH

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000238 Genomic DNA. Translation: ABF13890.1.
RefSeq	YP_588742.1. NC_007984.1.
3D structure databases
ProteinModelPortal	Q1LTH2.
SMR	Q1LTH2. Positions 1-306.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LTH2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4056475.
GenomeReviews	Gene locus BCI_0293 in contig CP000238_GR.
KEGG	bci:BCI_0293.
PATRIC	21074089. VBIBauCic75062_0279.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0462.
HOGENOM	HBG519284.
OMA	CATHAVF.
PhylomeDB	Q1LTH2.
ProtClustDB	PRK01259.
Enzyme and pathway databases
BioCyc	BCIC186490:BCI_0293-MONOMER.
Family and domain databases
HAMAP	MF_00583_B. RibP_PPkinase_B. [Tree]
InterPro	IPR000842. PRib_PP_synth_CS. IPR000836. PRibTrfase. IPR005946. Rib-P_diPkinase. [Graphical view]
KO	K00948.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01251. RibP_PPkin. 1 hit.
PROSITE	PS00114. PRPP_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPRS_BAUCH

Accession

Primary (citable) accession number: Q1LTH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 30, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program