ID   HIS4_BAUCH              Reviewed;         248 AA.
AC   Q1LT71;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
DE            EC=5.3.1.16;
DE   AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
GN   Name=hisA; OrderedLocusNames=BCI_0400;
OS   Baumannia cicadellinicola subsp. Homalodisca coagulata.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Candidatus Baumannia.
OX   NCBI_TaxID=374463;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16729848; DOI=10.1371/journal.pbio.0040188;
RA   Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L.,
RA   Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L.,
RA   Moran N.A., Eisen J.A.;
RT   "Metabolic complementarity and genomics of the dual bacterial
RT   symbiosis of sharpshooters.";
RL   PLoS Biol. 4:1079-1092(2006).
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5-
CC       phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-
CC       ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-
CC       phosphoribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the hisA/hisF family.
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DR   EMBL; CP000238; ABF13964.1; -; Genomic_DNA.
DR   RefSeq; YP_588843.1; -.
DR   GeneID; 4056710; -.
DR   GenomeReviews; CP000238_GR; BCI_0400.
DR   KEGG; bci:BCI_0400; -.
DR   HOGENOM; Q1LT71; -.
DR   OMA; Q1LT71; VATRGWL.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylam...; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01014; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006063; His4.
DR   InterPro; IPR006062; His_biosynth.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00977; His_biosynth; 1.
DR   TIGRFAMs; TIGR00007; His4; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Isomerase.
FT   CHAIN         1    248       1-(5-phosphoribosyl)-5-[(5-
FT                                phosphoribosylamino)methylideneamino]
FT                                imidazole-4-carboxamide isomerase.
FT                                /FTId=PRO_0000290451.
FT   ACT_SITE      7      7       Proton acceptor (By similarity).
FT   ACT_SITE    131    131       Proton donor (By similarity).
SQ   SEQUENCE   248 AA;  27482 MW;  BCF169091234E5E2 CRC64;
     MIIPALDLIN STVVRLHQGN YQQQRCYSDD PLYYLHNYLR QGAEMLHLVD LTGARDPSAR
     QIKLLTSLLA SVKGRTLVQV GGGIRNAADI EVMLQAGAHR VVIGSTAVKK PLEVQQWFKR
     FGPEALVLAL DIRIDTNGKH WVAVSGWMEN SGVLLEQVID QYTQQVELKN ILCTDISRDG
     TLSGMNIELY RLLCGNWPSI AFQSSGGIGS LTDIIKLRNI GVKGVIIGRA LLEEKFTLAE
     AIACWQKE
//