Reviewed, UniProtKB/Swiss-Prot Q1LT71 (HIS4_BAUCH)

Names and origin

Protein names

Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
    EC=5.3.1.16
Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

Name:	hisA
Ordered Locus Names:	BCI_0400

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. HAMAP MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP MF_01014
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the hisA/hisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP MF_01014		PRO_0000290451
Sites
	Active site	7	1	Proton acceptor By similarity
	Active site	131	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1LT71-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: BCF169091234E5E2	FASTA	248	27,482
	10 20 30 40 50 60 MIIPALDLIN STVVRLHQGN YQQQRCYSDD PLYYLHNYLR QGAEMLHLVD LTGARDPSAR 70 80 90 100 110 120 QIKLLTSLLA SVKGRTLVQV GGGIRNAADI EVMLQAGAHR VVIGSTAVKK PLEVQQWFKR 130 140 150 160 170 180 FGPEALVLAL DIRIDTNGKH WVAVSGWMEN SGVLLEQVID QYTQQVELKN ILCTDISRDG 190 200 210 220 230 240 TLSGMNIELY RLLCGNWPSI AFQSSGGIGS LTDIIKLRNI GVKGVIIGRA LLEEKFTLAE AIACWQKE

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000238 Genomic DNA. Translation: ABF13964.1.
RefSeq	YP_588843.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4056710.
GenomeReviews	Gene locus BCI_0400 in contig CP000238_GR.
KEGG	bci:BCI_0400.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1LT71.
OMA	Q1LT71. VATRGWL.
Family and domain databases
HAMAP	MF_01014. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006063. His4. IPR006062. His_biosynth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
TIGRFAMs	TIGR00007. His4. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS4_BAUCH

Accession

Primary (citable) accession number: Q1LT71

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	May 30, 2006
Last modified:	June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)