Reviewed, UniProtKB/Swiss-Prot Q1LSW6 (MURC_BAUCH)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylmuramate--L-alanine ligase
    EC=6.3.2.8
Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	BCI_0518

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation By similarity. HAMAP MF_00046
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm Probable HAMAP MF_00046.
Sequence similarities	Belongs to the murCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046		PRO_1000004312
Regions
	Nucleotide binding	126 – 132	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1LSW6-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: F3A3E80816739792	FASTA	490	54,695
	10 20 30 40 50 60 MNYQRLAQLQ KLVPQMRQVK RIHFIGIGGV GMSGIAKILL HEGYQISGSD LVQNKVTKHL 70 80 90 100 110 120 VALGVSIKFQ HIPENVLDAN VVVVSSAISI ANPEIVAAKK LRIPIITRAE MLAELMRFRY 130 140 150 160 170 180 GIAIAGTHGK TTTTAMLASI YLEAGLDPTI VNGGLIKSIG QYARLGYGSY LIAEADESDL 190 200 210 220 230 240 SFLHLQPIVT IITNIEADHM ENYQGDFNYL KNTFLKFIHK LPFYGKGIMC LDDPVIRDLL 250 260 270 280 290 300 PHISRHIITY GFNSKANFRL TNYHQKEAHV SFQLYRQDKP TLRIELNSPG RHNALNAVAA 310 320 330 340 350 360 IAVATEEGIA DKNILQALFR FKGINRRFDK LGCFSLKKIN GKNGVVMLVE DYGHHPTELQ 370 380 390 400 410 420 ATIQSVRIGW PDKRLVMVFQ PHRYTRTRDL YEYFVGVLSK VDVLLMLDIY PAGENPIAGI 430 440 450 460 470 480 DSKSLCCTIR NTSKLDPIFI HELNKLPVML AQLLQDNDLV LMQGAGSIGL IASQLAIGKL 490 QTNIRHNPLI

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000238 Genomic DNA. Translation: ABF13791.1.
RefSeq	YP_588948.1.
3D structure databases
SMR	Q1LSW6. Positions 1-481.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LSW6.
Genome annotation databases
GeneID	4056731.
GenomeReviews	Gene locus BCI_0518 in contig CP000238_GR.
KEGG	bci:BCI_0518.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0773.
HOGENOM	HBG476594.
OMA	YQPHRYS.
PhylomeDB	Q1LSW6.
Family and domain databases
HAMAP	MF_00046. MurC. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
TIGRFAMs	TIGR01082. murC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_BAUCH

Accession

Primary (citable) accession number: Q1LSW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 30, 2006
Last modified:	February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)