ID   TYSY_BAUCH              Reviewed;         264 AA.
AC   Q1LSU0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=Thymidylate synthase;
DE            Short=TS;
DE            Short=TSase;
DE            EC=2.1.1.45;
GN   Name=thyA; OrderedLocusNames=BCI_0544;
OS   Baumannia cicadellinicola subsp. Homalodisca coagulata.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Candidatus Baumannia.
OX   NCBI_TaxID=374463;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16729848; DOI=10.1371/journal.pbio.0040188;
RA   Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L.,
RA   Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L.,
RA   Moran N.A., Eisen J.A.;
RT   "Metabolic complementarity and genomics of the dual bacterial
RT   symbiosis of sharpshooters.";
RL   PLoS Biol. 4:1079-1092(2006).
CC   -!- FUNCTION: Provides the sole de novo source of dTMP for DNA
CC       biosynthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP =
CC       dihydrofolate + dTMP.
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the thymidylate synthase family. Bacterial-
CC       type thyA subfamily.
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DR   EMBL; CP000238; ABF14145.1; -; Genomic_DNA.
DR   RefSeq; YP_588974.1; -.
DR   SMR; Q1LSU0; 2-264.
DR   GeneID; 4056574; -.
DR   GenomeReviews; CP000238_GR; BCI_0544.
DR   KEGG; bci:BCI_0544; -.
DR   HOGENOM; Q1LSU0; -.
DR   OMA; Q1LSU0; LGPVYGH.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:HAMAP.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00008; -; 1.
DR   InterPro; IPR000398; Thymidylat_synth_C.
DR   Gene3D; G3DSA:3.30.572.10; Thymidylat_synth_C; 1.
DR   PANTHER; PTHR11549:SF2; Thymidylat_synth_C; 1.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   ProDom; PD001180; Thymidylat_synth; 1.
DR   TIGRFAMs; TIGR03284; thym_sym; 1.
DR   PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase;
KW   Nucleotide biosynthesis; Transferase.
FT   CHAIN         1    264       Thymidylate synthase.
FT                                /FTId=PRO_1000000580.
FT   ACT_SITE    146    146       By similarity.
SQ   SEQUENCE   264 AA;  30768 MW;  57095B2167E128D3 CRC64;
     MKQYLELMRL VRTQGISKVD RTNTGTLSIF GHQMRFNLSH GFPLITTKRC HLRSIIYELL
     WFLNGDTNIN YLRKHHVTIW DEWINEKGDL GPIYGRQWRA WGTADGSYID QLSDVMLQLK
     HNPDSRRIIV SAWNVGEIKQ MALAPCHVLF QFYVANGVLS CQLYQRSCDM FLGLPFNISS
     YALLIHMVAQ QCDLQLGEFI WTGGDIHLYR NHLKQTDLQL KRNPRPLPQL IIKRRPASLF
     QYQFDDFYLS GYDPHPAIKA QVAV
//