Reviewed, UniProtKB/Swiss-Prot Q1LSU0 (TYSY_BAUCH)

Names and origin

Protein names

Recommended name:
    Thymidylate synthase
      Short name=TS
      Short name=TSase
    EC=2.1.1.45

Gene names

Name:	thyA
Ordered Locus Names:	BCI_0544

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.
Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008
Pathway	Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thymidylate synthase family. Bacterial-type thyA subfamily.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dTMP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thymidylate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Thymidylate synthase HAMAP MF_00008		PRO_1000000580
Sites
	Active site	146	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1LSU0-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 57095B2167E128D3	FASTA	264	30,768
	10 20 30 40 50 60 MKQYLELMRL VRTQGISKVD RTNTGTLSIF GHQMRFNLSH GFPLITTKRC HLRSIIYELL 70 80 90 100 110 120 WFLNGDTNIN YLRKHHVTIW DEWINEKGDL GPIYGRQWRA WGTADGSYID QLSDVMLQLK 130 140 150 160 170 180 HNPDSRRIIV SAWNVGEIKQ MALAPCHVLF QFYVANGVLS CQLYQRSCDM FLGLPFNISS 190 200 210 220 230 240 YALLIHMVAQ QCDLQLGEFI WTGGDIHLYR NHLKQTDLQL KRNPRPLPQL IIKRRPASLF 250 260 QYQFDDFYLS GYDPHPAIKA QVAV

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000238 Genomic DNA. Translation: ABF14145.1.
RefSeq	YP_588974.1.
3D structure databases
SMR	Q1LSU0. Positions 2-264.
ModBase	Search...
Genome annotation databases
GeneID	4056574.
GenomeReviews	Gene locus BCI_0544 in contig CP000238_GR.
KEGG	bci:BCI_0544.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1LSU0.
OMA	Q1LSU0. LGPVYGH.
Family and domain databases
HAMAP	MF_00008. [Tree]
InterPro	IPR000398. Thymidylat_synth_C. [Graphical view]
Gene3D	G3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
PANTHER	PTHR11549:SF2. Thymidylat_synth_C. 1 hit.
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
ProDom	PD001180. Thymidylat_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_BAUCH

Accession

Primary (citable) accession number: Q1LSU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 30, 2006
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)