Reviewed, UniProtKB/Swiss-Prot Q1LSS3 (APAH_BAUCH)

Names and origin

Protein names

Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
    EC=3.6.1.41
Alternative name(s):
    Diadenosine tetraphosphatase
    Ap4A hydrolase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase

Gene names

Name:	apaH
Ordered Locus Names:	BCI_0562

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012045

Sequences

	Sequence		Length	Mass (Da)
	Q1LSS3-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: F0BF5E76254BA1E2	FASTA	288	33,032
	10 20 30 40 50 60 MSTYFIGDIH GCYDELQTIL EKVAFDPLID TLWLTGDLVA RGPSSLEVLR MIRRLGNSVR 70 80 90 100 110 120 IVLGNHDLHL LAVYTGIMRN RIKDHTIPLL TAPDAEDLMN WLRYQPVLQV DNKKKILMAH 130 140 150 160 170 180 AGITPQWNID TALQCASEIE TVLRSESYPL FLHSIYEDIP NYWSNELSYR ARLQFSTNVF 190 200 210 220 230 240 TRMRYCFPNG KLDMLCKDIP NKAPEPLRPW FNLPSTIVEK YSIIFGHWSS LLGKGTPTGI 250 260 270 280 YGLDTGCCWG GKLTLLCWED KKIIQIPSQK KRNKKCSYLC YNGKGKKN

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000238 Genomic DNA. Translation: ABF13981.1.
RefSeq	YP_588991.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4056411.
GenomeReviews	Gene locus BCI_0562 in contig CP000238_GR.
KEGG	bci:BCI_0562.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1LSS3.
OMA	Q1LSS3. LVFGHWA.
Family and domain databases
HAMAP	MF_00199. [Tree]
InterPro	IPR004617. ApaH. IPR004843. M-pesterase. IPR006186. T_phtase_apaH. [Graphical view]
PANTHER	PTHR11668. T_phtase_apaH. 1 hit.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_BAUCH

Accession

Primary (citable) accession number: Q1LSS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 30, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)