Reviewed, UniProtKB/Swiss-Prot Q1LSM0 (GCP_BAUCH)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	BCI_0619

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata [Complete proteome] [HAMAP]

Taxonomic identifier

374463 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Baumannia

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303278
Sites
	Metal binding	111	1	Zinc Potential
	Metal binding	115	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1LSM0-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 2442D005E726E524	FASTA	341	36,891
	10 20 30 40 50 60 MRVLGIETSC DDTGVAIYDD QHGLLTNQIY SQAKIHANYG GVVPELASRD HLRKIVPLIQ 70 80 90 100 110 120 AALSEARLQA KNIDGVAYTA GPGLISSLMV GATVGCALAY AWKVPNIAVH HMEGHLLAPM 130 140 150 160 170 180 LEINPPSFPF VALLVSGAHT QLIAVTKMGK YQLLGQSVDD AVGEAFDKTA KLLGLDYPGG 190 200 210 220 230 240 PMLSKIAQQG IAGRYKFPRP MTERPGLNFS FAGLKTFAAN TINIAASDAQ THADIARAFE 250 260 270 280 290 300 DAVVDTLMIK CQRALDQTGF KRLVMAGGVS ANQTLRNRMK KMVEQRGEEI FYARPELCTD 310 320 330 340 NGAMIAYVGS VRFASLVLPQ SQLAVIVRPR WPLEELTTIS R

References

[1]

"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters." Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A. PLoS Biol. 4:1079-1092(2006) [PubMed: 16729848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000238 Genomic DNA. Translation: ABF13921.1.
RefSeq	YP_589044.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LSM0.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	4056367.
GenomeReviews	Gene locus BCI_0619 in contig CP000238_GR.
KEGG	bci:BCI_0619.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1LSM0.
OMA	MEVIGQT.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_BAUCH

Accession

Primary (citable) accession number: Q1LSM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 30, 2006
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)