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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.UniRule annotation

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12SubstrateUniRule annotation1
Binding sitei16SubstrateUniRule annotation1
Active sitei64Proton donor/acceptorUniRule annotation1
Binding sitei91SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotation (EC:4.2.3.3UniRule annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:Rmet_0792
OrganismiCupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000178241 – 140Methylglyoxal synthaseAdd BLAST140

Interactioni

Protein-protein interaction databases

STRINGi266264.Rmet_0792

Structurei

3D structure databases

ProteinModelPortaliQ1LQ98
SMRiQ1LQ98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 140MGS-likeUniRule annotationAdd BLAST140

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 41Substrate bindingUniRule annotation4
Regioni58 – 59Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z5K Bacteria
COG1803 LUCA
HOGENOMiHOG000283729
KOiK01734
OMAiRACDVHN
OrthoDBiPOG091H04UH

Family and domain databases

CDDicd01422 MGS, 1 hit
Gene3Di3.40.50.1380, 1 hit
HAMAPiMF_00549 Methylglyoxal_synth, 1 hit
InterProiView protein in InterPro
IPR004363 Methylgl_synth
IPR018148 Methylglyoxal_synth_AS
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
PANTHERiPTHR30492 PTHR30492, 1 hit
PfamiView protein in Pfam
PF02142 MGS, 1 hit
PIRSFiPIRSF006614 Methylglyox_syn, 1 hit
SMARTiView protein in SMART
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
TIGRFAMsiTIGR00160 MGSA, 1 hit
PROSITEiView protein in PROSITE
PS01335 METHYLGLYOXAL_SYNTH, 1 hit
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q1LQ98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSKPRIALI AHDRKKDDIV AFAGRHRDFL AQCDLLATGT TGGRIAAETG
60 70 80 90 100
LPVARMLSGP WGGDLQIGAQ LAEGRVTAVV FLRDPMTPQP HEPDINALVR
110 120 130 140
ACDVHNVPCA TNLATAELVV VELARICFEE DQAAADDAAP
Length:140
Mass (Da):14,934
Last modified:May 30, 2006 - v1
Checksum:i0BEC4FB86A44B433
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA Translation: ABF07678.1
RefSeqiWP_011515630.1, NC_007973.1

Genome annotation databases

EnsemblBacteriaiABF07678; ABF07678; Rmet_0792
GeneIDi24150175
KEGGirme:Rmet_0792

Similar proteinsi

Entry informationi

Entry nameiMGSA_CUPMC
AccessioniPrimary (citable) accession number: Q1LQ98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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