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Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83L-glutamineUniRule annotation1
Binding sitei235L-glutamineUniRule annotation1
Binding sitei254ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 53ATPUniRule annotation3
Nucleotide bindingi57 – 63ATPUniRule annotation7
Nucleotide bindingi289 – 290ATPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligaseUniRule annotation (EC:6.1.1.18UniRule annotation)
Alternative name(s):
Glutaminyl-tRNA synthetaseUniRule annotation
Short name:
GlnRSUniRule annotation
Gene namesi
Name:glnSUniRule annotation
Ordered Locus Names:Rmet_0818
OrganismiCupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000955061 – 582Glutamine--tRNA ligaseAdd BLAST582

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi266264.Rmet_0818.

Structurei

3D structure databases

ProteinModelPortaliQ1LQ72.
SMRiQ1LQ72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 60"HIGH" regionUniRule annotationAdd BLAST11
Motifi296 – 300"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CX6. Bacteria.
COG0008. LUCA.
HOGENOMiHOG000259232.
KOiK01886.
OMAiVTHSICT.
OrthoDBiPOG091H00G9.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 3 hits.
HAMAPiMF_00126. Gln_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_N.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LQ72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHDTKPNDT PAASNFLRSI IDQDLATGTY AGRADKQGDP LPTVITRFPP
60 70 80 90 100
EPNGYLHIGH AKSICVNFGL ARDYAGRCHL RFDDTNPVKE DTEYVDSIID
110 120 130 140 150
AVHWLGFSWD SAQAGSTPHL YFASDYFDQL YKFAETLIER GVAYVDSQSA
160 170 180 190 200
EQIAAMRGNF SEPGKPSPFR DRSVEENLKL FREMRDGKYA DGEHVLRAKI
210 220 230 240 250
DMTAPNIVMR DPVLYRIRHA HHHRTGDKWC IYPMYDFTHC ISDAIENITH
260 270 280 290 300
SLCTLEFENN RPLYDWVLEH LRDAGVFANP LPHQYEFARL NLTYAITSKR
310 320 330 340 350
RLKQLVDEQR VTGWDDPRMP TIVGIRRRGY TPESIQLFCD RVGVSKADSW
360 370 380 390 400
IDMSTLEGAV RDDLDARAPR SVAVLDPLKL ILDNYPEGQS EECSAPVHPK
410 420 430 440 450
QPEMGRRVFP LSRELWIERE DFNENPPKGY FRLFPGNKVR LRYGYVIECT
460 470 480 490 500
GVDKDADGNV IAVHANYLPE TKSGTPGADS VKVKGNIHWV SAPHACEAEV
510 520 530 540 550
RLYDRLFNDP NPDAGGKNFL DALNPESKKV VTAYLEPGLR DAKPEDRFQF
560 570 580
ERHGYFVADR VDSQPGKPVF NRTVGLKDSW GK
Length:582
Mass (Da):66,121
Last modified:May 30, 2006 - v1
Checksum:i688FBD9447623404
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA. Translation: ABF07704.1.
RefSeqiWP_011515648.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF07704; ABF07704; Rmet_0818.
GeneIDi24150149.
KEGGirme:Rmet_0818.

Similar proteinsi

Entry informationi

Entry nameiSYQ_CUPMC
AccessioniPrimary (citable) accession number: Q1LQ72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 30, 2006
Last modified: November 22, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families