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Q1LPE1

- GCH41_RALME

UniProt

Q1LPE1 - GCH41_RALME

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Protein
GTP cyclohydrolase FolE2 1
Gene
folE2-1, Rmet_1099
Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-1146-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 1 (EC:3.5.4.16)
Gene namesi
Name:folE2-1
Ordered Locus Names:Rmet_1099
OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309GTP cyclohydrolase FolE2 1UniRule annotation
PRO_0000289517Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266264.Rmet_1099.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1LPE1-1 [UniParc]FASTAAdd to Basket

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MSAALPDVSL TEASPTFTPL EWVGMQGIDL PIRLVEPGYR RQLHARADIH    50
VDLPAPRVKG IHMSRLYALL DALDDGEGLS PIRIRQLLEA MVDSHRDCET 100
GSARLRLRFD LLVRRPALVT EGIAGWKSYP VRLDASLVGN VFALTARITA 150
GYSSTCPCSA ALTRQLVEQG FAKAFAHERR VDVARVSAWL RQHGTLATPH 200
SQRSEASITV DIAVDLPNLG LLDLVDHIER ALGTPVQTAV KRADEQAFAA 250
LNGQNLMFVE DAARRIQVAL DGRFANPRVH VRHLESLHPH DAVAWAAPLQ 300
MKHSREVAA 309
Length:309
Mass (Da):33,970
Last modified:May 5, 2009 - v2
Checksum:iFFF204BF8A9293C6
GO

Sequence cautioni

The sequence ABF07985.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF07985.1. Different initiation.
RefSeqiYP_583254.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF07985; ABF07985; Rmet_1099.
GeneIDi4037897.
KEGGirme:Rmet_1099.
PATRICi20286778. VBIRalMet4734_1496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF07985.1 . Different initiation.
RefSeqi YP_583254.1. NC_007973.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 266264.Rmet_1099.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF07985 ; ABF07985 ; Rmet_1099 .
GeneIDi 4037897.
KEGGi rme:Rmet_1099.
PATRICi 20286778. VBIRalMet4734_1496.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci CMET266264:GJ5G-1146-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH34 / ATCC 43123 / DSM 2839.

Entry informationi

Entry nameiGCH41_RALME
AccessioniPrimary (citable) accession number: Q1LPE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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