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Q1LPE1

- GCH41_RALME

UniProt

Q1LPE1 - GCH41_RALME

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Protein

GTP cyclohydrolase FolE2 1

Gene

folE2-1

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-1146-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2-1UniRule annotation
Ordered Locus Names:Rmet_1099
OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309GTP cyclohydrolase FolE2 1PRO_0000289517Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266264.Rmet_1099.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1LPE1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAALPDVSL TEASPTFTPL EWVGMQGIDL PIRLVEPGYR RQLHARADIH
60 70 80 90 100
VDLPAPRVKG IHMSRLYALL DALDDGEGLS PIRIRQLLEA MVDSHRDCET
110 120 130 140 150
GSARLRLRFD LLVRRPALVT EGIAGWKSYP VRLDASLVGN VFALTARITA
160 170 180 190 200
GYSSTCPCSA ALTRQLVEQG FAKAFAHERR VDVARVSAWL RQHGTLATPH
210 220 230 240 250
SQRSEASITV DIAVDLPNLG LLDLVDHIER ALGTPVQTAV KRADEQAFAA
260 270 280 290 300
LNGQNLMFVE DAARRIQVAL DGRFANPRVH VRHLESLHPH DAVAWAAPLQ

MKHSREVAA
Length:309
Mass (Da):33,970
Last modified:May 5, 2009 - v2
Checksum:iFFF204BF8A9293C6
GO

Sequence cautioni

The sequence ABF07985.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA. Translation: ABF07985.1. Different initiation.
RefSeqiYP_583254.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF07985; ABF07985; Rmet_1099.
GeneIDi4037897.
KEGGirme:Rmet_1099.
PATRICi20286778. VBIRalMet4734_1496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA. Translation: ABF07985.1 . Different initiation.
RefSeqi YP_583254.1. NC_007973.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266264.Rmet_1099.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF07985 ; ABF07985 ; Rmet_1099 .
GeneIDi 4037897.
KEGGi rme:Rmet_1099.
PATRICi 20286778. VBIRalMet4734_1496.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci CMET266264:GJ5G-1146-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH34 / ATCC 43123 / DSM 2839.

Entry informationi

Entry nameiGCH41_RALME
AccessioniPrimary (citable) accession number: Q1LPE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: October 1, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3