Q1LNS3 (ACDH1_RALME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase 1
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1

Gene names

Ordered Locus Names:

Rmet_1320

Organism

Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) [Complete proteome] [HAMAP]

Taxonomic identifier

266264 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus › Cupriavidus metallidurans

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: HAMAP acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Acetaldehyde dehydrogenase 1 HAMAP-Rule MF_01657		PRO_0000387714
Regions
	Nucleotide binding	161 – 169	9	NAD By similarity
Sites
	Active site	130	1	Acyl-thioester intermediate By similarity
	Binding site	272	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1LNS3 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: EF590C5280B84A9F	FASTA	303	32,332
	10 20 30 40 50 60 MKKIKCALIG PGNIGTDLLA KLKRSSVLEP VWMVGIDPES EGLNRARELG IKTTAEGVDG 70 80 90 100 110 120 LLPHVLADGV QIAFDATSAY VHAENARKLN ALGVMMIDLT PAAIGPYCVP PVNLKEHLGK 130 140 150 160 170 180 REMNVNMVTC GGQATIPMVA AVSRVQPVAY GEIVATVSSR SVGPGTRKNI DEFTRTTAGA 190 200 210 220 230 240 VEKVGGARKG KAIIIINPAE PPLMMRDTIH CLTETEPDQQ RIAESIHAMI EEVQKYVPGY 250 260 270 280 290 300 RLVNGPVFDG KRVTVFMEVA GLGDYLPTYA GNLDIMTAAA ARTAEMFAEE MIAGNLTLEP VVA

References

[1]

"Complete sequence of the chromosome of Ralstonia metallidurans CH34." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Martinez M., Goltsman E., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Mergeay M., Benotmane M.A., Vallaeys T., Michaux A., Monchy S., Dunn J., McCorkle S., Taghavi S., van der Lelie D., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CH34 / ATCC 43123 / DSM 2839.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000352 Genomic DNA. Translation: ABF08203.1.
RefSeq	YP_583472.1. NC_007973.1.
3D structure databases
ProteinModelPortal	Q1LNS3.
SMR	Q1LNS3. Positions 2-293.
ModBase	Search...
Protein-protein interaction databases
STRING	266264.Rmet_1320.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABF08203; ABF08203; Rmet_1320.
GeneID	4038123.
KEGG	rme:Rmet_1320.
PATRIC	20287248. VBIRalMet4734_1726.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HOG000052149.
KO	K04073.
OMA	TSAYVHK.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	CMET266264:GJ5G-1381-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01657. Ac_ald_DH_ac.
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. PTHR21123. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH1_RALME

Accession

Primary (citable) accession number: Q1LNS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	May 30, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program