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Q1LNE5

- LPXB_RALME

UniProt

Q1LNE5 - LPXB_RALME

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-1509-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Rmet_1448
OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Lipid-A-disaccharide synthasePRO_0000255212Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266264.Rmet_1448.

Structurei

3D structure databases

ProteinModelPortaliQ1LNE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LNE5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDTVQAVLP ADAGANGNKR GSIAMVAGEA SGDLLASLLL EGLRARLGES
60 70 80 90 100
VDYAGIGGHR MMAQGFVSHW PMETLSVNGY VEVLGSLREI LATRREIREQ
110 120 130 140 150
LLARPPLCFI GVDAPDFNFG LEVPLRRAGI PVVHFVSPSI WAWRGGRIRT
160 170 180 190 200
IARAVDHILC LFPFEPEIYA KAGIPATYVG HPLADVIPMV PDVAGARAKL
210 220 230 240 250
ALPEGKRIVA VLPGSRQSEV RNLGATFFAA MDRMHRMDGN LAFVLPVASA
260 270 280 290 300
PLREIVAGLH AQYPDIDLTV VDGQSHLAME SADVVLLASG TATLEAALYK
310 320 330 340 350
KPMVISYKVP WLTAQIMKRQ GYLPYVGLPN ILSGRFVVPE LLQDDATPEA
360 370 380 390 400
LARETLLQLN DEGNIAFLRQ HFTTMHETLK RDTAKLAAGV VVDLMRSRGV

V
Length:401
Mass (Da):43,417
Last modified:May 30, 2006 - v1
Checksum:iC02EB9CE4BB11AAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF08331.1.
RefSeqiWP_011516197.1. NC_007973.1.
YP_583600.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF08331; ABF08331; Rmet_1448.
GeneIDi4038251.
KEGGirme:Rmet_1448.
PATRICi20287510. VBIRalMet4734_1857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF08331.1 .
RefSeqi WP_011516197.1. NC_007973.1.
YP_583600.1. NC_007973.1.

3D structure databases

ProteinModelPortali Q1LNE5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266264.Rmet_1448.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF08331 ; ABF08331 ; Rmet_1448 .
GeneIDi 4038251.
KEGGi rme:Rmet_1448.
PATRICi 20287510. VBIRalMet4734_1857.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CMET266264:GJ5G-1509-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH34 / ATCC 43123 / DSM 2839.

Entry informationi

Entry nameiLPXB_RALME
AccessioniPrimary (citable) accession number: Q1LNE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 30, 2006
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3