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Q1LNE5

- LPXB_RALME

UniProt

Q1LNE5 - LPXB_RALME

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Rmet_1448
Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-1509-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Rmet_1448
OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000255212Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266264.Rmet_1448.

Structurei

3D structure databases

ProteinModelPortaliQ1LNE5.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LNE5-1 [UniParc]FASTAAdd to Basket

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MVDTVQAVLP ADAGANGNKR GSIAMVAGEA SGDLLASLLL EGLRARLGES    50
VDYAGIGGHR MMAQGFVSHW PMETLSVNGY VEVLGSLREI LATRREIREQ 100
LLARPPLCFI GVDAPDFNFG LEVPLRRAGI PVVHFVSPSI WAWRGGRIRT 150
IARAVDHILC LFPFEPEIYA KAGIPATYVG HPLADVIPMV PDVAGARAKL 200
ALPEGKRIVA VLPGSRQSEV RNLGATFFAA MDRMHRMDGN LAFVLPVASA 250
PLREIVAGLH AQYPDIDLTV VDGQSHLAME SADVVLLASG TATLEAALYK 300
KPMVISYKVP WLTAQIMKRQ GYLPYVGLPN ILSGRFVVPE LLQDDATPEA 350
LARETLLQLN DEGNIAFLRQ HFTTMHETLK RDTAKLAAGV VVDLMRSRGV 400
V 401
Length:401
Mass (Da):43,417
Last modified:May 30, 2006 - v1
Checksum:iC02EB9CE4BB11AAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF08331.1.
RefSeqiWP_011516197.1. NC_007973.1.
YP_583600.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF08331; ABF08331; Rmet_1448.
GeneIDi4038251.
KEGGirme:Rmet_1448.
PATRICi20287510. VBIRalMet4734_1857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF08331.1 .
RefSeqi WP_011516197.1. NC_007973.1.
YP_583600.1. NC_007973.1.

3D structure databases

ProteinModelPortali Q1LNE5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 266264.Rmet_1448.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF08331 ; ABF08331 ; Rmet_1448 .
GeneIDi 4038251.
KEGGi rme:Rmet_1448.
PATRICi 20287510. VBIRalMet4734_1857.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CMET266264:GJ5G-1509-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH34 / ATCC 43123 / DSM 2839.

Entry informationi

Entry nameiLPXB_RALME
AccessioniPrimary (citable) accession number: Q1LNE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 30, 2006
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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