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Protein

D-(-)-3-hydroxybutyrate oligomer hydrolase

Gene

Rmet_1960

Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Participates in the degradation of poly-3-hydroxybutyrate (PHB). It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D--3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers.UniRule annotation

Catalytic activityi

(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O = 2 (R)-3-hydroxybutanoate.UniRule annotation

Pathwayi: butanoate metabolism

This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei327 – 3271Charge relay systemUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-2068-MONOMER.
UniPathwayiUPA00863.

Names & Taxonomyi

Protein namesi
Recommended name:
D-(-)-3-hydroxybutyrate oligomer hydrolaseUniRule annotation (EC:3.1.1.22UniRule annotation)
Short name:
3HB-oligomer hydrolaseUniRule annotation
Short name:
3HBOHUniRule annotation
Gene namesi
Ordered Locus Names:Rmet_1960
OrganismiCupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002429 Componenti: Chromosome

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636UniRule annotationAdd
BLAST
Chaini37 – 722686D-(-)-3-hydroxybutyrate oligomer hydrolasePRO_5000118750Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266264.Rmet_1960.

Family & Domainsi

Sequence similaritiesi

Belongs to the D-(-)-3-hydroxybutyrate oligomer hydrolase family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106BE1. Bacteria.
ENOG410XSMB. LUCA.
HOGENOMiHOG000263490.
KOiK07518.
OMAiNPEKDWG.
OrthoDBiPOG091H117N.

Family and domain databases

HAMAPiMF_01906. 3HBOH. 1 hit.
InterProiIPR016582. OHBut_olig_hydro_put.
[Graphical view]
PfamiPF10605. 3HBOH. 1 hit.
[Graphical view]
PIRSFiPIRSF011409. HObutyrate_olig_hydrol. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1LLY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQRHLSQSA HSHGHGTRRA HRRNTIAIAV ATLAVAACGG FGTNGSGGNT
60 70 80 90 100
GPNVKPAFIS GPVGVKSYDG NTDDLLTAGL GKDGLAAAAP AFANPNAPTA
110 120 130 140 150
VELRRNAIWA NYRAIVDVQA AGGYGSLYGP NVDAKGNVTT GQGKVPGTEY
160 170 180 190 200
IAFTDDGSGR QNVTVMAQVP DGFDVKHPCI ISATSSGSRG VYGGIAVGEW
210 220 230 240 250
GLKHNCAVAY TDKGTGAAPH DLGSDTVPLI DGTRQTRAGA GTQAQFAAQP
260 270 280 290 300
GASETLAGFN SSTPHRLAFK HAHSQQNPEA NWGANTLQAI QFTLWAVNDK
310 320 330 340 350
FGRTNTDGMR QATFTPANVL VIASAISNGG GAAIAAAEQD TGGLIDGVAV
360 370 380 390 400
GEPNVNLPPT AGVVVKRGGV PVAASGKHLY DYTTIANLYQ LCASQDASLG
410 420 430 440 450
NAPFAKTAGQ AALNRCASLA AKKMIAGGST SAQATSALDA LHRAGWEPES
460 470 480 490 500
DDLFASLSAL EVGSSISVTY ANAYARASVT DRLCHYSFSS PGSPPQANPV
510 520 530 540 550
TAPAAALAGL FSTGNGIPPT TAVTLMNDAN PSGAMRDFTS ISPSTKLADG
560 570 580 590 600
NVDGALCLRG LLDTRNPALM TGIGQTYRTG NLGGRPSVIV QGRSDGLLPV
610 620 630 640 650
NHTSRPYLGL NKHVEGASSR LSYIEVTNGQ HFDGFIDVIP GYAKRYIPMH
660 670 680 690 700
VYVNRALDAV YANLRDGTPL PPSQVVRTTP RGGADTDTVG PRIQPSNVPP
710 720
IAATPAAGDA ITVTGSTVDV PN
Length:722
Mass (Da):73,917
Last modified:May 30, 2006 - v1
Checksum:i911C2C8140F5A68D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA. Translation: ABF08839.1.
RefSeqiWP_011516685.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF08839; ABF08839; Rmet_1960.
GeneIDi24149004.
KEGGirme:Rmet_1960.
PATRICi20288548. VBIRalMet4734_2373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA. Translation: ABF08839.1.
RefSeqiWP_011516685.1. NC_007973.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266264.Rmet_1960.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF08839; ABF08839; Rmet_1960.
GeneIDi24149004.
KEGGirme:Rmet_1960.
PATRICi20288548. VBIRalMet4734_2373.

Phylogenomic databases

eggNOGiENOG4106BE1. Bacteria.
ENOG410XSMB. LUCA.
HOGENOMiHOG000263490.
KOiK07518.
OMAiNPEKDWG.
OrthoDBiPOG091H117N.

Enzyme and pathway databases

UniPathwayiUPA00863.
BioCyciCMET266264:GJ5G-2068-MONOMER.

Family and domain databases

HAMAPiMF_01906. 3HBOH. 1 hit.
InterProiIPR016582. OHBut_olig_hydro_put.
[Graphical view]
PfamiPF10605. 3HBOH. 1 hit.
[Graphical view]
PIRSFiPIRSF011409. HObutyrate_olig_hydrol. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHBOH_CUPMC
AccessioniPrimary (citable) accession number: Q1LLY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.