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Q1LK35

- GCH42_RALME

UniProt

Q1LK35 - GCH42_RALME

Protein

GTP cyclohydrolase FolE2 2

Gene

folE2-2

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei153 – 1531May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciCMET266264:GJ5G-2788-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2 2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2-2UniRule annotation
    Ordered Locus Names:Rmet_2614
    OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
    Taxonomic identifieri266264 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267GTP cyclohydrolase FolE2 2PRO_0000289516Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266264.Rmet_2614.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1LK35.
    SMRiQ1LK35. Positions 21-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiAKWFFDR.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1LK35-1 [UniParc]FASTAAdd to Basket

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    MNDINPAFVM PDVQSSVDTR QIVIQRVGVK GVRYPLTLKT PAGAVGTVGT    50
    FNMDVRLPAD QKGTHMSRFV ALLEENRAPL DLAAFRALVD DMLVRLEADA 100
    GRIEVSFPYF ITKTAPVSGV QSLLDYEVTL VAEARDGQTR MFMTALVPVT 150
    SLCPCSKKIS QYGAHNQRSH ITMRVELAGD LDVEALVRMA EEEASCELWG 200
    LLKRPDEKFV TERAYENPKF VEDLVRDIAM RLNADDRIVA YTLEAENFES 250
    IHNHSAYAVI EHDKRHQ 267
    Length:267
    Mass (Da):29,908
    Last modified:May 30, 2006 - v1
    Checksum:i09A8A32B70A92D9B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000352 Genomic DNA. Translation: ABF09491.1.
    RefSeqiYP_584760.1. NC_007973.1.

    Genome annotation databases

    EnsemblBacteriaiABF09491; ABF09491; Rmet_2614.
    GeneIDi4039440.
    KEGGirme:Rmet_2614.
    PATRICi20289872. VBIRalMet4734_3015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000352 Genomic DNA. Translation: ABF09491.1 .
    RefSeqi YP_584760.1. NC_007973.1.

    3D structure databases

    ProteinModelPortali Q1LK35.
    SMRi Q1LK35. Positions 21-264.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266264.Rmet_2614.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF09491 ; ABF09491 ; Rmet_2614 .
    GeneIDi 4039440.
    KEGGi rme:Rmet_2614.
    PATRICi 20289872. VBIRalMet4734_3015.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi AKWFFDR.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci CMET266264:GJ5G-2788-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH34 / ATCC 43123 / DSM 2839.

    Entry informationi

    Entry nameiGCH42_RALME
    AccessioniPrimary (citable) accession number: Q1LK35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3