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Q1LJU9

- TRMB_RALME

UniProt

Q1LJU9 - TRMB_RALME

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei92 – 921S-adenosyl-L-methionineUniRule annotation
    Binding sitei117 – 1171S-adenosyl-L-methionineUniRule annotation
    Binding sitei144 – 1441S-adenosyl-L-methionineUniRule annotation
    Active sitei167 – 1671By similarity
    Binding sitei167 – 1671S-adenosyl-L-methionineUniRule annotation
    Binding sitei171 – 1711SubstrateUniRule annotation
    Binding sitei203 – 2031SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCMET266264:GJ5G-2886-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Rmet_2704
    OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
    Taxonomic identifieri266264 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262tRNA (guanine-N(7)-)-methyltransferasePRO_0000288208Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266264.Rmet_2704.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1LJU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni173 – 1786Interaction with RNAUniRule annotation
    Regioni241 – 2444Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiHSTLEMA.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1LJU9-1 [UniParc]FASTAAdd to Basket

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    MLPQDTNTDP LPGDDAESAS GKSADASQGT PNPGDEVAHP RRIRSFVRRA    50
    GRTSTGQQRA MDELGPTYIV PYQPEPLDWT ATFGREAPSI LEIGFGMGET 100
    TAHIAGLRSQ DNFLGCEVHE PGVGALLKLI GERGLQNVRI MQHDAVEVAA 150
    HMLTENSLDG VHIYFPDPWH KKRHNKRRLV QPPLVKLLAS RLKPGGYIHC 200
    ATDWEEYAHQ MVEVLSGEPA LENTSKADGG FAERPDYRPV TKFEKRGLRL 250
    GHGVWDVVFR KK 262
    Length:262
    Mass (Da):29,030
    Last modified:May 30, 2006 - v1
    Checksum:i325EF93273C5BACB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000352 Genomic DNA. Translation: ABF09577.1.
    RefSeqiWP_011517275.1. NC_007973.1.
    YP_584846.1. NC_007973.1.

    Genome annotation databases

    EnsemblBacteriaiABF09577; ABF09577; Rmet_2704.
    GeneIDi4039530.
    KEGGirme:Rmet_2704.
    PATRICi20290053. VBIRalMet4734_3103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000352 Genomic DNA. Translation: ABF09577.1 .
    RefSeqi WP_011517275.1. NC_007973.1.
    YP_584846.1. NC_007973.1.

    3D structure databases

    ProteinModelPortali Q1LJU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266264.Rmet_2704.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF09577 ; ABF09577 ; Rmet_2704 .
    GeneIDi 4039530.
    KEGGi rme:Rmet_2704.
    PATRICi 20290053. VBIRalMet4734_3103.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi HSTLEMA.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CMET266264:GJ5G-2886-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH34 / ATCC 43123 / DSM 2839.

    Entry informationi

    Entry nameiTRMB_RALME
    AccessioniPrimary (citable) accession number: Q1LJU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3