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Q1LJU8 (UPPP_RALME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Rmet_2705
OrganismRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) [Complete proteome] [HAMAP]
Taxonomic identifier266264 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000250251

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane238 – 25821Helical; Potential
Transmembrane269 – 28921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q1LJU8 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 6C6A7F9F5981D22B

FASTA29331,757
        10         20         30         40         50         60 
MDIALALKAV ILGIVEGLTE FLPISSTGHL ILAGQLLDFN DEKGKIFEIV IQFGAILAVC 

        70         80         90        100        110        120 
WEFRQRIGTV ISGLASDVKS QRFAVNVIVA TIPAIVLALV FGKWIKAHLF NPITVATAFI 

       130        140        150        160        170        180 
IGGVVILLAE WREARRGTVS APQGNALLEA AKAGAPRIES VDDLNWRDAL KVGLAQCFAL 

       190        200        210        220        230        240 
VPGTSRSGAT IIGGMLFGLS RQVATEFSFF LAIPVIFGAT VYELYKARAL LSADDLGIFA 

       250        260        270        280        290 
VGFVFAFLSA FLCVRWLLRF VATHDFKPFA WYRIAFGIIV LLTAWTGVIS WHA 

« Hide

References

[1]"Complete sequence of the chromosome of Ralstonia metallidurans CH34."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Martinez M., Goltsman E., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Mergeay M., Benotmane M.A., Vallaeys T., Michaux A., Monchy S., Dunn J., McCorkle S., Taghavi S., van der Lelie D., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CH34 / ATCC 43123 / DSM 2839.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000352 Genomic DNA. Translation: ABF09578.1.
RefSeqYP_584847.1. NC_007973.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266264.Rmet_2705.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF09578; ABF09578; Rmet_2705.
GeneID4039531.
KEGGrme:Rmet_2705.
PATRIC20290055. VBIRalMet4734_3104.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycCMET266264:GJ5G-2887-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_RALME
AccessionPrimary (citable) accession number: Q1LJU8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: May 30, 2006
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families