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Q1LJR3 (PYRB_RALME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aspartate carbamoyltransferase

EC=2.1.3.2
Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase
Gene names
Name:pyrB
Ordered Locus Names:Rmet_2740
OrganismRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) [Complete proteome] [HAMAP]
Taxonomic identifier266264 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001

Sequence similarities

Belongs to the ATCase/OTCase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Aspartate carbamoyltransferase HAMAP-Rule MF_00001
PRO_0000321147

Sequences

Sequence LengthMass (Da)Tools
Q1LJR3 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 1BAE62504717E8A1

FASTA32335,248
        10         20         30         40         50         60 
MTKTFRNPQL TKNGELKHLL SIEGLSRDMI THILDTASQF VSLSDSDREV KKVPLLRGKS 

        70         80         90        100        110        120 
VFNLFFENST RTRTTFEIAA KRLSADVLNL NINASSTSKG ESLLDTINNL SAMSADMFVV 

       130        140        150        160        170        180 
RHASSGAPYL IAEHVAPHVH VINAGDGRHA HPTQGLLDMY TIRHFKKDFT NLTVAIVGDI 

       190        200        210        220        230        240 
LHSRVARSDI HALTTLGVPE VRAIGPRTLL PSGLEQMGVR VFHNMEEGLK GVDVVIMLRL 

       250        260        270        280        290        300 
QNERMTGALL PSAQEYFKAY GLTPERLALA KPDAIVMHPG PMNRGVEIDS AVADGPQSVI 

       310        320 
LNQVTFGIAV RMAVMGIVAG NND 

« Hide

References

[1]"Complete sequence of the chromosome of Ralstonia metallidurans CH34."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Martinez M., Goltsman E., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Mergeay M., Benotmane M.A., Vallaeys T., Michaux A., Monchy S., Dunn J., McCorkle S., Taghavi S., van der Lelie D., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CH34 / ATCC 43123 / DSM 2839.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000352 Genomic DNA. Translation: ABF09613.1.

3D structure databases

ProteinModelPortalQ1LJR3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266264.Rmet_2740.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF09613; ABF09613; Rmet_2740.
KEGGrme:Rmet_2740.
PATRIC20290119. VBIRalMet4734_3136.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0540.
HOGENOMHOG000022685.
OMAVMTLRLQ.
OrthoDBEOG61KBJZ.
ProtClustDBPRK00856.

Enzyme and pathway databases

BioCycCMET266264:GJ5G-2926-MONOMER.
UniPathwayUPA00070; UER00116.

Family and domain databases

Gene3D3.40.50.1370. 2 hits.
HAMAPMF_00001. Asp_carb_tr.
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMSSF53671. SSF53671. 1 hit.
TIGRFAMsTIGR00670. asp_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRB_RALME
AccessionPrimary (citable) accession number: Q1LJR3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways