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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase (glutamine-hydrolyzing) (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC), Dihydroorotase (allB), Dihydroorotase (pyrX)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-2926-MONOMER.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:Rmet_2740
OrganismiCupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Aspartate carbamoyltransferasePRO_0000321147Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266264.Rmet_2740.

Structurei

3D structure databases

ProteinModelPortaliQ1LJR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT. Bacteria.
COG0540. LUCA.
HOGENOMiHOG000022685.
KOiK00609.
OMAiMHPGPMV.
OrthoDBiPOG091H00PQ.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1LJR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTFRNPQL TKNGELKHLL SIEGLSRDMI THILDTASQF VSLSDSDREV
60 70 80 90 100
KKVPLLRGKS VFNLFFENST RTRTTFEIAA KRLSADVLNL NINASSTSKG
110 120 130 140 150
ESLLDTINNL SAMSADMFVV RHASSGAPYL IAEHVAPHVH VINAGDGRHA
160 170 180 190 200
HPTQGLLDMY TIRHFKKDFT NLTVAIVGDI LHSRVARSDI HALTTLGVPE
210 220 230 240 250
VRAIGPRTLL PSGLEQMGVR VFHNMEEGLK GVDVVIMLRL QNERMTGALL
260 270 280 290 300
PSAQEYFKAY GLTPERLALA KPDAIVMHPG PMNRGVEIDS AVADGPQSVI
310 320
LNQVTFGIAV RMAVMGIVAG NND
Length:323
Mass (Da):35,248
Last modified:May 30, 2006 - v1
Checksum:i1BAE62504717E8A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA. Translation: ABF09613.1.
RefSeqiWP_008646281.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF09613; ABF09613; Rmet_2740.
GeneIDi24151852.
KEGGirme:Rmet_2740.
PATRICi20290119. VBIRalMet4734_3136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA. Translation: ABF09613.1.
RefSeqiWP_008646281.1. NC_007973.1.

3D structure databases

ProteinModelPortaliQ1LJR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266264.Rmet_2740.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF09613; ABF09613; Rmet_2740.
GeneIDi24151852.
KEGGirme:Rmet_2740.
PATRICi20290119. VBIRalMet4734_3136.

Phylogenomic databases

eggNOGiENOG4105CXT. Bacteria.
COG0540. LUCA.
HOGENOMiHOG000022685.
KOiK00609.
OMAiMHPGPMV.
OrthoDBiPOG091H00PQ.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116.
BioCyciCMET266264:GJ5G-2926-MONOMER.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRB_CUPMC
AccessioniPrimary (citable) accession number: Q1LJR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 30, 2006
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.