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Q1LJC9

- Q1LJC9_RALME

UniProt

Q1LJC9 - Q1LJC9_RALME

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Protein

Quinolinate synthase A

Gene

nadA

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotationSAAS annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotation

Cofactori

Binds 1 4Fe-4S cluster per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651IminoaspartateUniRule annotation
Binding sitei86 – 861Iminoaspartate; via amide nitrogenUniRule annotation
Binding sitei157 – 1571IminoaspartateUniRule annotation
Binding sitei174 – 1741IminoaspartateUniRule annotation
Binding sitei244 – 2441IminoaspartateUniRule annotation
Binding sitei261 – 2611IminoaspartateUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. methyltransferase activity Source: UniProtKB-KW
  4. quinolinate synthetase A activity Source: UniProtKB-HAMAP
  5. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-3069-MONOMER.
UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotationSAAS annotation (EC:2.5.1.72UniRule annotationSAAS annotation)
Gene namesi
Name:nadAUniRule annotationImported
Ordered Locus Names:Rmet_2874Imported
OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)Imported
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002429: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi266264.Rmet_2874.

Structurei

3D structure databases

ProteinModelPortaliQ1LJC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0379.
HOGENOMiHOG000222769.
KOiK03517.
OMAiKTVLMPT.
OrthoDBiEOG6DJZ56.

Family and domain databases

HAMAPiMF_00567. NadA_type1.
InterProiIPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LJC9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPQTIKSVE FEKPNLTDPD AAAGGSCVAH AWAKVPPALT PDERQALKSR
60 70 80 90 100
IRKLLKERNA VLVAHYYVDA DLQDLAEETG GCVSDSLEMA RFGRDHDAKT
110 120 130 140 150
LVVAGVRFMG ETAKILSPEK TILMPDLDAT CSLDLGCPAD DFSAFCDAHP
160 170 180 190 200
DRTVVVYANT SAAVKARADW MVTSSIGLKI VEHLHARGEK ILWAPDKHLG
210 220 230 240 250
SYIQQQTGAD MLLWQGSCLV HDEFKGIELD LLRREHPKAK ILVHPESPAN
260 270 280 290 300
VVAQADVVGS TSQLIAAAQQ LDANEFIVAT DNGILHKMRM AAPGKMFIEA
310 320 330 340 350
PTAGNSATCK SCAHCPWMAM NALTNLAEVL ETGRNEIHVD ADIGRRAVTC
360 370 380
INRMLDFAAQ QKANVRPAAD LAKESALFSG VGPA
Length:384
Mass (Da):41,438
Last modified:May 30, 2006 - v1
Checksum:i9B09C4BD4C736272
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF09747.1.
RefSeqiYP_585016.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF09747; ABF09747; Rmet_2874.
GeneIDi4039702.
KEGGirme:Rmet_2874.
PATRICi20290375. VBIRalMet4734_3263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF09747.1 .
RefSeqi YP_585016.1. NC_007973.1.

3D structure databases

ProteinModelPortali Q1LJC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266264.Rmet_2874.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF09747 ; ABF09747 ; Rmet_2874 .
GeneIDi 4039702.
KEGGi rme:Rmet_2874.
PATRICi 20290375. VBIRalMet4734_3263.

Phylogenomic databases

eggNOGi COG0379.
HOGENOMi HOG000222769.
KOi K03517.
OMAi KTVLMPT.
OrthoDBi EOG6DJZ56.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00327 .
BioCyci CMET266264:GJ5G-3069-MONOMER.

Family and domain databases

HAMAPi MF_00567. NadA_type1.
InterProi IPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view ]
Pfami PF02445. NadA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00550. nadA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH34 / ATCC 43123 / DSM 2839Imported.

Entry informationi

Entry nameiQ1LJC9_RALME
AccessioniPrimary (citable) accession number: Q1LJC9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3