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Q1LJC9

- Q1LJC9_RALME

UniProt

Q1LJC9 - Q1LJC9_RALME

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Protein

Quinolinate synthase A

Gene
nadA, Rmet_2874
Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotations

Cofactori

Binds 1 4Fe-4S cluster per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651Iminoaspartate By similarityUniRule annotation
Binding sitei86 – 861Iminoaspartate; via amide nitrogen By similarityUniRule annotation
Binding sitei157 – 1571Iminoaspartate By similarityUniRule annotation
Binding sitei174 – 1741Iminoaspartate By similarityUniRule annotation
Binding sitei244 – 2441Iminoaspartate By similarityUniRule annotation
Binding sitei261 – 2611Iminoaspartate By similarityUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. methyltransferase activity Source: UniProtKB-KW
  4. quinolinate synthetase A activity Source: UniProtKB-HAMAP
  5. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotations, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-3069-MONOMER.
UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotationImported
Ordered Locus Names:Rmet_2874Imported
OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)Imported
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002429: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi266264.Rmet_2874.

Structurei

3D structure databases

ProteinModelPortaliQ1LJC9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0379.
HOGENOMiHOG000222769.
KOiK03517.
OMAiKTVLMPT.
OrthoDBiEOG6DJZ56.

Family and domain databases

HAMAPiMF_00567. NadA_type1.
InterProiIPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LJC9-1 [UniParc]FASTAAdd to Basket

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MTPQTIKSVE FEKPNLTDPD AAAGGSCVAH AWAKVPPALT PDERQALKSR    50
IRKLLKERNA VLVAHYYVDA DLQDLAEETG GCVSDSLEMA RFGRDHDAKT 100
LVVAGVRFMG ETAKILSPEK TILMPDLDAT CSLDLGCPAD DFSAFCDAHP 150
DRTVVVYANT SAAVKARADW MVTSSIGLKI VEHLHARGEK ILWAPDKHLG 200
SYIQQQTGAD MLLWQGSCLV HDEFKGIELD LLRREHPKAK ILVHPESPAN 250
VVAQADVVGS TSQLIAAAQQ LDANEFIVAT DNGILHKMRM AAPGKMFIEA 300
PTAGNSATCK SCAHCPWMAM NALTNLAEVL ETGRNEIHVD ADIGRRAVTC 350
INRMLDFAAQ QKANVRPAAD LAKESALFSG VGPA 384
Length:384
Mass (Da):41,438
Last modified:May 30, 2006 - v1
Checksum:i9B09C4BD4C736272
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF09747.1.
RefSeqiYP_585016.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF09747; ABF09747; Rmet_2874.
GeneIDi4039702.
KEGGirme:Rmet_2874.
PATRICi20290375. VBIRalMet4734_3263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF09747.1 .
RefSeqi YP_585016.1. NC_007973.1.

3D structure databases

ProteinModelPortali Q1LJC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266264.Rmet_2874.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF09747 ; ABF09747 ; Rmet_2874 .
GeneIDi 4039702.
KEGGi rme:Rmet_2874.
PATRICi 20290375. VBIRalMet4734_3263.

Phylogenomic databases

eggNOGi COG0379.
HOGENOMi HOG000222769.
KOi K03517.
OMAi KTVLMPT.
OrthoDBi EOG6DJZ56.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00327 .
BioCyci CMET266264:GJ5G-3069-MONOMER.

Family and domain databases

HAMAPi MF_00567. NadA_type1.
InterProi IPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view ]
Pfami PF02445. NadA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00550. nadA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH34 / ATCC 43123 / DSM 2839.

Entry informationi

Entry nameiQ1LJC9_RALME
AccessioniPrimary (citable) accession number: Q1LJC9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3