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Q1LJC9

- Q1LJC9_RALME

UniProt

Q1LJC9 - Q1LJC9_RALME

Protein

Quinolinate synthase A

Gene

nadA

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotationSAAS annotation

    Catalytic activityi

    Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei65 – 651IminoaspartateUniRule annotation
    Binding sitei86 – 861Iminoaspartate; via amide nitrogenUniRule annotation
    Binding sitei157 – 1571IminoaspartateUniRule annotation
    Binding sitei174 – 1741IminoaspartateUniRule annotation
    Binding sitei244 – 2441IminoaspartateUniRule annotation
    Binding sitei261 – 2611IminoaspartateUniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. methyltransferase activity Source: UniProtKB-KW
    4. quinolinate synthetase A activity Source: UniProtKB-HAMAP
    5. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    MethyltransferaseImported, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciCMET266264:GJ5G-3069-MONOMER.
    UniPathwayiUPA00253; UER00327.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
    Gene namesi
    Name:nadAUniRule annotationImported
    Ordered Locus Names:Rmet_2874Imported
    OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)Imported
    Taxonomic identifieri266264 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002429: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi266264.Rmet_2874.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1LJC9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the quinolinate synthase A family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0379.
    HOGENOMiHOG000222769.
    KOiK03517.
    OMAiKTVLMPT.
    OrthoDBiEOG6DJZ56.

    Family and domain databases

    HAMAPiMF_00567. NadA_type1.
    InterProiIPR003473. NadA.
    IPR023513. Quinolinate_synth_A_type1.
    [Graphical view]
    PfamiPF02445. NadA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00550. nadA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1LJC9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPQTIKSVE FEKPNLTDPD AAAGGSCVAH AWAKVPPALT PDERQALKSR    50
    IRKLLKERNA VLVAHYYVDA DLQDLAEETG GCVSDSLEMA RFGRDHDAKT 100
    LVVAGVRFMG ETAKILSPEK TILMPDLDAT CSLDLGCPAD DFSAFCDAHP 150
    DRTVVVYANT SAAVKARADW MVTSSIGLKI VEHLHARGEK ILWAPDKHLG 200
    SYIQQQTGAD MLLWQGSCLV HDEFKGIELD LLRREHPKAK ILVHPESPAN 250
    VVAQADVVGS TSQLIAAAQQ LDANEFIVAT DNGILHKMRM AAPGKMFIEA 300
    PTAGNSATCK SCAHCPWMAM NALTNLAEVL ETGRNEIHVD ADIGRRAVTC 350
    INRMLDFAAQ QKANVRPAAD LAKESALFSG VGPA 384
    Length:384
    Mass (Da):41,438
    Last modified:May 30, 2006 - v1
    Checksum:i9B09C4BD4C736272
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000352 Genomic DNA. Translation: ABF09747.1.
    RefSeqiYP_585016.1. NC_007973.1.

    Genome annotation databases

    EnsemblBacteriaiABF09747; ABF09747; Rmet_2874.
    GeneIDi4039702.
    KEGGirme:Rmet_2874.
    PATRICi20290375. VBIRalMet4734_3263.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000352 Genomic DNA. Translation: ABF09747.1 .
    RefSeqi YP_585016.1. NC_007973.1.

    3D structure databases

    ProteinModelPortali Q1LJC9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266264.Rmet_2874.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF09747 ; ABF09747 ; Rmet_2874 .
    GeneIDi 4039702.
    KEGGi rme:Rmet_2874.
    PATRICi 20290375. VBIRalMet4734_3263.

    Phylogenomic databases

    eggNOGi COG0379.
    HOGENOMi HOG000222769.
    KOi K03517.
    OMAi KTVLMPT.
    OrthoDBi EOG6DJZ56.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00327 .
    BioCyci CMET266264:GJ5G-3069-MONOMER.

    Family and domain databases

    HAMAPi MF_00567. NadA_type1.
    InterProi IPR003473. NadA.
    IPR023513. Quinolinate_synth_A_type1.
    [Graphical view ]
    Pfami PF02445. NadA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00550. nadA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH34 / ATCC 43123 / DSM 2839Imported.

    Entry informationi

    Entry nameiQ1LJC9_RALME
    AccessioniPrimary (citable) accession number: Q1LJC9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 30, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3