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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Rmet_2911
OrganismiCupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002583901 – 350Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST350

Proteomic databases

PRIDEiQ1LJ92

Interactioni

Protein-protein interaction databases

STRINGi266264.Rmet_2911

Structurei

3D structure databases

ProteinModelPortaliQ1LJ92
SMRiQ1LJ92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
HOGENOMiHOG000229090
KOiK01933
OMAiNHCVNDI
OrthoDBiPOG091H0128

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

Q1LJ92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASPTAGQA GLSYRDAGVD IEAGDALVDR IKPFAKRTMR EGVMAGIGGF
60 70 80 90 100
GALFELSKKY QEPVLVSGTD GVGTKLKLAF QLNRHDTVGQ DLVAMSVNDI
110 120 130 140 150
LVQGAEPLFF LDYFACGKLD VETAATVIKG IAHGCELAGC ALIGGETAEM
160 170 180 190 200
PSMYPDGEYD LAGFAVGAVE KKKIIDGSTI TPGDVVLGLA SSGAHSNGYS
210 220 230 240 250
LVRKIIDVAR PNLDADFHGQ RLQDAIMAPT RIYVKPLLSL IETLPVKGMA
260 270 280 290 300
HITGGGLTEN VPRVLADNVT AVIQRDAWTL PPLFQWLQAE GRVADAEMHR
310 320 330 340 350
VFNCGIGMVV IVAKEDAERA IRHLQAAGEA VWQIGEIRER AEGQAQTVVV
Length:350
Mass (Da):37,197
Last modified:May 30, 2006 - v1
Checksum:iF8001336D599FB45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA Translation: ABF09784.1
RefSeqiWP_008641981.1, NC_007973.1

Genome annotation databases

EnsemblBacteriaiABF09784; ABF09784; Rmet_2911
GeneIDi24151684
KEGGirme:Rmet_2911

Entry informationi

Entry nameiPUR5_CUPMC
AccessioniPrimary (citable) accession number: Q1LJ92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 30, 2006
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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