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Q1LJ30

- SYL_RALME

UniProt

Q1LJ30 - SYL_RALME

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei639 – 6391ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCMET266264:GJ5G-3174-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Rmet_2973
    OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
    Taxonomic identifieri266264 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002429: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 873873Leucine--tRNA ligasePRO_1000009406Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266264.Rmet_2973.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1LJ30.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi48 – 5811"HIGH" regionAdd
    BLAST
    Motifi636 – 6405"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1LJ30-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDKYLPSAV EQAAQQHWKA IDAYKVSEHA VGPDGKEKSK FYACSMLPYP    50
    SGKLHMGHVR NYTINDVMAR YLRMNGRNVL MPMGWDAFGM PAENAALNNG 100
    VAPAAWTYDN IAYMKKQMQS MGLAIDWSRE VATCSPEYYR WNQWLFLKML 150
    EKGIAYRKTG TVNWDPVDQT VLANEQVIDG RGWRSGAVVE KREIPMYYLR 200
    ITDYAQELLG DLEGLGWPER VKIMQQNWIG RSEGVRFAFP HEIKGADGKL 250
    INDGKLYVFT TRADTIMGVT FCAVAAEHPL ATHAAESNPA LAAFIEECKH 300
    GSVMEADMAT MEKKGMPTGL KVTHPLTGEQ VDVWVGNYVL MTYGDGAVMG 350
    VPAHDERDFA FALKYNLPIK QVIDVKGQAY STDAWLEWYG DKEHGLCIHS 400
    GKYDGLGYKA AVDAIAADLA AKGLGEKKVT WRLRDWGISR QRYWGTPIPL 450
    IHCDSCGVVP VPEKDLPVVL PEDLVPDGTG NPLAKDPRFL ECTCPSCGKP 500
    ARRETDTMDT FIDSCWYYMR YTCPDAGTMV DARNDYWMPM DQYIGGIEHA 550
    ILHLLYARFW TKVMRDMGLV KFDEPFTNLL TQGMVLNETF YREDASGKKT 600
    WYNPADVDVQ TDERGRPAGA TAKADGQPVV IGGIEKMSKS KNNGIDPQAL 650
    IDQYGADTAR LFVMFAAPPE QQLEWSGSGV EGASRFLRRV WNYGYANAQA 700
    IRDGAGTAPT ADDAALRREI HTVLKQANYD YERIQYNTVV SATMKMLNAL 750
    EDAKTASPAG RREGFSVLLR VLYPVVPHIA HGLWQELGYA AETVDILDAA 800
    WPQVDEAALV RSEIELVLQV NGKVRGSLTV PADADRAAIE ATAAASEIVA 850
    KFAAGAAPKK IVVVPGRLVN VVL 873
    Length:873
    Mass (Da):96,869
    Last modified:May 30, 2006 - v1
    Checksum:i5641A1642E217597
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000352 Genomic DNA. Translation: ABF09846.1.
    RefSeqiWP_011517508.1. NC_007973.1.
    YP_585115.1. NC_007973.1.

    Genome annotation databases

    EnsemblBacteriaiABF09846; ABF09846; Rmet_2973.
    GeneIDi4039801.
    KEGGirme:Rmet_2973.
    PATRICi20290585. VBIRalMet4734_3368.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000352 Genomic DNA. Translation: ABF09846.1 .
    RefSeqi WP_011517508.1. NC_007973.1.
    YP_585115.1. NC_007973.1.

    3D structure databases

    ProteinModelPortali Q1LJ30.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266264.Rmet_2973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF09846 ; ABF09846 ; Rmet_2973 .
    GeneIDi 4039801.
    KEGGi rme:Rmet_2973.
    PATRICi 20290585. VBIRalMet4734_3368.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CMET266264:GJ5G-3174-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH34 / ATCC 43123 / DSM 2839.

    Entry informationi

    Entry nameiSYL_RALME
    AccessioniPrimary (citable) accession number: Q1LJ30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3