Q1LIV0 (Q1LIV0_RALME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE HAMAP MF_00222
Ordered Locus Names:	Rmet_3054

Organism

Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) [Complete proteome] [HAMAP]

Taxonomic identifier

266264 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222 EMBL ABF09926.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	143 – 147	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	82	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	Q1LIV0 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 080F001F2A988D48	FASTA	302	32,214
	10 20 30 40 50 60 MTADQNSQPN TAEPADSVDR YVVVGNPISH SRSPAIHAAF ARQTGEAVQY DRLEAPLDAF 70 80 90 100 110 120 ADTMREFLAG GGHGFNVTVP FKLEAYDLAD RLTPRAEAAG AVNTMWIEDG LIHGDNTDGI 130 140 150 160 170 180 GLVRDIQDNL DVLLEDKRIL VLGAGGAAMG AMLPLIECRP ARIVVANRTA SRASDMVEEF 190 200 210 220 230 240 VEAADQYNVE LWAGGLDALD ALSEDERCDV VINASSSSLQ GEVPPVPEHL LGEGVLAYDM 250 260 270 280 290 300 MYGAQPTVFL AYAAKCGART ADGLGMLVEQ AAEAFYNWRG VRPSTAPVLA ELRAALQAEA AR

References

[1]

"Complete sequence of the chromosome of Ralstonia metallidurans CH34." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Martinez M., Goltsman E., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Mergeay M., Benotmane M.A., Vallaeys T., Michaux A., Monchy S., Dunn J., McCorkle S., Taghavi S., van der Lelie D., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CH34 / ATCC 43123 / DSM 2839.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000352 Genomic DNA. Translation: ABF09926.1.
RefSeq	YP_585195.1. NC_007973.1.
3D structure databases
ProteinModelPortal	Q1LIV0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LIV0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4039882.
GenomeReviews	Gene locus Rmet_3054 in contig CP000352_GR.
KEGG	rme:Rmet_3054.
PATRIC	20290739. VBIRalMet4734_3445.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	VVFGNPI.
PhylomeDB	Q1LIV0.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	RMET266264:RMET_3054-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q1LIV0_RALME

Accession

Primary (citable) accession number: Q1LIV0

Entry history

Integrated into UniProtKB/TrEMBL:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)