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Protein

Probable chorismate pyruvate-lyase

Gene

ubiC

Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.UniRule annotation

Catalytic activityi

Chorismate = 4-hydroxybenzoate + pyruvate.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741SubstrateUniRule annotation
Binding sitei112 – 1121Substrate; via amide nitrogenUniRule annotation
Binding sitei173 – 1731SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-3263-MONOMER.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable chorismate pyruvate-lyaseUniRule annotation (EC:4.1.3.40UniRule annotation)
Short name:
CLUniRule annotation
Short name:
CPLUniRule annotation
Gene namesi
Name:ubiCUniRule annotation
Ordered Locus Names:Rmet_3058
OrganismiCupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Probable chorismate pyruvate-lyasePRO_0000255911Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266264.Rmet_3058.

Structurei

3D structure databases

ProteinModelPortaliQ1LIU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410807V. Bacteria.
COG3161. LUCA.
HOGENOMiHOG000137785.
KOiK03181.
OrthoDBiPOG091H047C.

Family and domain databases

Gene3Di3.40.1410.10. 1 hit.
HAMAPiMF_01632. UbiC. 1 hit.
InterProiIPR007440. Chorismate--pyruvate_lyase.
IPR028978. Chorismate_lyase_/UTRA_dom.
[Graphical view]
PfamiPF04345. Chor_lyase. 1 hit.
[Graphical view]
SUPFAMiSSF64288. SSF64288. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LIU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKLRAAWHA HLPYDASIPL NQRRWITGEG SLTARLMSAS AAFRVRRLAQ
60 70 80 90 100
APQLPLADEW RALGLIRPLP AITREVLLIC DETPAVFAHT IVDPRYARRD
110 120 130 140 150
WPFLRGLGNR PLGGALFVDP RVRRDPFQFA RLTPCHPLRQ ALQRVLPALS
160 170 180 190 200
SEPMLPARRS VFRRGGGAML VTEVFLPDLL TRAAPENTGA GGTRLPRRID
210
THHTPSKQEE RPES
Length:214
Mass (Da):24,061
Last modified:October 31, 2006 - v2
Checksum:iF1EC498766F0D862
GO

Sequence cautioni

The sequence ABF09930 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA. Translation: ABF09930.1. Different initiation.
RefSeqiWP_029307163.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF09930; ABF09930; Rmet_3058.
GeneIDi24151537.
KEGGirme:Rmet_3058.
PATRICi20290747. VBIRalMet4734_3449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA. Translation: ABF09930.1. Different initiation.
RefSeqiWP_029307163.1. NC_007973.1.

3D structure databases

ProteinModelPortaliQ1LIU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266264.Rmet_3058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF09930; ABF09930; Rmet_3058.
GeneIDi24151537.
KEGGirme:Rmet_3058.
PATRICi20290747. VBIRalMet4734_3449.

Phylogenomic databases

eggNOGiENOG410807V. Bacteria.
COG3161. LUCA.
HOGENOMiHOG000137785.
KOiK03181.
OrthoDBiPOG091H047C.

Enzyme and pathway databases

UniPathwayiUPA00232.
BioCyciCMET266264:GJ5G-3263-MONOMER.

Family and domain databases

Gene3Di3.40.1410.10. 1 hit.
HAMAPiMF_01632. UbiC. 1 hit.
InterProiIPR007440. Chorismate--pyruvate_lyase.
IPR028978. Chorismate_lyase_/UTRA_dom.
[Graphical view]
PfamiPF04345. Chor_lyase. 1 hit.
[Graphical view]
SUPFAMiSSF64288. SSF64288. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBIC_CUPMC
AccessioniPrimary (citable) accession number: Q1LIU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.