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Q1LHM2

- GCSP_RALME

UniProt

Q1LHM2 - GCSP_RALME

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Rmet_3482
Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-3729-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Rmet_3482
OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 974974Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei720 – 7201N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi266264.Rmet_3482.

Structurei

3D structure databases

ProteinModelPortaliQ1LHM2.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LHM2-1 [UniParc]FASTAAdd to Basket

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MNAPLPMNAA AQGARPTLAE LEARDAFAAR HIGPDSAEQQ HMLKVLGFES    50
RAALIDAVVP AAIRRRDGMS LGEFTAPLTE EAALGRLRAL AGKNRVLKSF 100
IGQGYYNTLT PGVILRNIFE NPAWYTAYTP YQPEISQGRL EAMLNFQQMI 150
TDLTGLDIAN ASMLDEGTAA AEAMTLLQRV NKHASNTFYV AEDVLPQTLE 200
VVRTRALPLG IEVKVGPAAD AAQAHAFGVL LQYPGVNGDV ADYRAIAEAV 250
HASGGRVVAA ADLLALTLIA APGEWGADVT VGNSQRFGVP LGFGGPHAGY 300
MAVKDEFKRS MPGRLVGVTI DAQGNKAYRL ALQTREQHIR REKATSNICT 350
AQVLLAVMAS MYAVYHGPQG LKRIAQRVHR LTATLAAGLK TLGHTPLNAT 400
FFDTLTLETG FNTDAFHASA TARGINLRHV DATRIGISFD ETASRDDVIA 450
LWEIFAHGKA VPDFDTIEAS VQDGFPATLA RQSAYLTHPV FNTHHAEHEM 500
LRYLRALADK DLALDRTMIP LGSCTMKLNA TSEMIPVTWP EFSNIHPFAP 550
LDQTVGYREM IDQLEAMLCA ATGYAAVSLQ PNAGSQGEYA GLLIIHAYHA 600
SRGESHRDIC LIPSSAHGTN PASAQMAGMK VVVVACDENG NVDLADLAKK 650
AEQHSKNLAA IMITYPSTHG VFEQGVQQIC DIVHKHGGQV YVDGANMNAM 700
VGVAAPGQFG GDVSHLNLHK TFCIPHGGGG PGVGPVAVGA HLADFLPNQD 750
SVGYRRDENG IGGVSAAPFG SASILPISWM YIAMMGSAGL TAATENAILT 800
ANYVARRLSP HFPVLYTGQH GLVAHECILD LRPLQKATGI SNEDVAKRLM 850
DYGFHAPTMS FPVPGTLMIE PTESEALHEL DRFIDAMIAI RGEIARVEDG 900
SFDREDNPLK HAPHTAAVVV SDKWNHKYTR EEAAYPVASL RTQKYWPPVG 950
RADNVYGDRN LFCSCVPLSE YAED 974
Length:974
Mass (Da):104,819
Last modified:May 30, 2006 - v1
Checksum:iF79B97D16F9279DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF10354.1.
RefSeqiWP_011517911.1. NC_007973.1.
YP_585623.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF10354; ABF10354; Rmet_3482.
GeneIDi4040330.
KEGGirme:Rmet_3482.
PATRICi20291641. VBIRalMet4734_3878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF10354.1 .
RefSeqi WP_011517911.1. NC_007973.1.
YP_585623.1. NC_007973.1.

3D structure databases

ProteinModelPortali Q1LHM2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266264.Rmet_3482.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF10354 ; ABF10354 ; Rmet_3482 .
GeneIDi 4040330.
KEGGi rme:Rmet_3482.
PATRICi 20291641. VBIRalMet4734_3878.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CMET266264:GJ5G-3729-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH34 / ATCC 43123 / DSM 2839.

Entry informationi

Entry nameiGCSP_RALME
AccessioniPrimary (citable) accession number: Q1LHM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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