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Q1LHM2 (GCSP_RALME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Rmet_3482
OrganismRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) [Complete proteome] [HAMAP]
Taxonomic identifier266264 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus

Protein attributes

Sequence length974 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 974974Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045598

Amino acid modifications

Modified residue7201N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1LHM2 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: F79B97D16F9279DC

FASTA974104,819
        10         20         30         40         50         60 
MNAPLPMNAA AQGARPTLAE LEARDAFAAR HIGPDSAEQQ HMLKVLGFES RAALIDAVVP 

        70         80         90        100        110        120 
AAIRRRDGMS LGEFTAPLTE EAALGRLRAL AGKNRVLKSF IGQGYYNTLT PGVILRNIFE 

       130        140        150        160        170        180 
NPAWYTAYTP YQPEISQGRL EAMLNFQQMI TDLTGLDIAN ASMLDEGTAA AEAMTLLQRV 

       190        200        210        220        230        240 
NKHASNTFYV AEDVLPQTLE VVRTRALPLG IEVKVGPAAD AAQAHAFGVL LQYPGVNGDV 

       250        260        270        280        290        300 
ADYRAIAEAV HASGGRVVAA ADLLALTLIA APGEWGADVT VGNSQRFGVP LGFGGPHAGY 

       310        320        330        340        350        360 
MAVKDEFKRS MPGRLVGVTI DAQGNKAYRL ALQTREQHIR REKATSNICT AQVLLAVMAS 

       370        380        390        400        410        420 
MYAVYHGPQG LKRIAQRVHR LTATLAAGLK TLGHTPLNAT FFDTLTLETG FNTDAFHASA 

       430        440        450        460        470        480 
TARGINLRHV DATRIGISFD ETASRDDVIA LWEIFAHGKA VPDFDTIEAS VQDGFPATLA 

       490        500        510        520        530        540 
RQSAYLTHPV FNTHHAEHEM LRYLRALADK DLALDRTMIP LGSCTMKLNA TSEMIPVTWP 

       550        560        570        580        590        600 
EFSNIHPFAP LDQTVGYREM IDQLEAMLCA ATGYAAVSLQ PNAGSQGEYA GLLIIHAYHA 

       610        620        630        640        650        660 
SRGESHRDIC LIPSSAHGTN PASAQMAGMK VVVVACDENG NVDLADLAKK AEQHSKNLAA 

       670        680        690        700        710        720 
IMITYPSTHG VFEQGVQQIC DIVHKHGGQV YVDGANMNAM VGVAAPGQFG GDVSHLNLHK 

       730        740        750        760        770        780 
TFCIPHGGGG PGVGPVAVGA HLADFLPNQD SVGYRRDENG IGGVSAAPFG SASILPISWM 

       790        800        810        820        830        840 
YIAMMGSAGL TAATENAILT ANYVARRLSP HFPVLYTGQH GLVAHECILD LRPLQKATGI 

       850        860        870        880        890        900 
SNEDVAKRLM DYGFHAPTMS FPVPGTLMIE PTESEALHEL DRFIDAMIAI RGEIARVEDG 

       910        920        930        940        950        960 
SFDREDNPLK HAPHTAAVVV SDKWNHKYTR EEAAYPVASL RTQKYWPPVG RADNVYGDRN 

       970 
LFCSCVPLSE YAED 

« Hide

References

[1]"Complete sequence of the chromosome of Ralstonia metallidurans CH34."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Martinez M., Goltsman E., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Mergeay M., Benotmane M.A., Vallaeys T., Michaux A., Monchy S., Dunn J., McCorkle S., Taghavi S., van der Lelie D., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CH34 / ATCC 43123 / DSM 2839.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000352 Genomic DNA. Translation: ABF10354.1.
RefSeqYP_585623.1. NC_007973.1.

3D structure databases

ProteinModelPortalQ1LHM2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266264.Rmet_3482.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF10354; ABF10354; Rmet_3482.
GeneID4040330.
PATRIC20291641. VBIRalMet4734_3878.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycCMET266264:GJ5G-3729-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RALME
AccessionPrimary (citable) accession number: Q1LHM2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families