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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-3729-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Rmet_3482
OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 974974Glycine dehydrogenase (decarboxylating)PRO_1000045598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei720 – 7201N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi266264.Rmet_3482.

Structurei

3D structure databases

ProteinModelPortaliQ1LHM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LHM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAPLPMNAA AQGARPTLAE LEARDAFAAR HIGPDSAEQQ HMLKVLGFES
60 70 80 90 100
RAALIDAVVP AAIRRRDGMS LGEFTAPLTE EAALGRLRAL AGKNRVLKSF
110 120 130 140 150
IGQGYYNTLT PGVILRNIFE NPAWYTAYTP YQPEISQGRL EAMLNFQQMI
160 170 180 190 200
TDLTGLDIAN ASMLDEGTAA AEAMTLLQRV NKHASNTFYV AEDVLPQTLE
210 220 230 240 250
VVRTRALPLG IEVKVGPAAD AAQAHAFGVL LQYPGVNGDV ADYRAIAEAV
260 270 280 290 300
HASGGRVVAA ADLLALTLIA APGEWGADVT VGNSQRFGVP LGFGGPHAGY
310 320 330 340 350
MAVKDEFKRS MPGRLVGVTI DAQGNKAYRL ALQTREQHIR REKATSNICT
360 370 380 390 400
AQVLLAVMAS MYAVYHGPQG LKRIAQRVHR LTATLAAGLK TLGHTPLNAT
410 420 430 440 450
FFDTLTLETG FNTDAFHASA TARGINLRHV DATRIGISFD ETASRDDVIA
460 470 480 490 500
LWEIFAHGKA VPDFDTIEAS VQDGFPATLA RQSAYLTHPV FNTHHAEHEM
510 520 530 540 550
LRYLRALADK DLALDRTMIP LGSCTMKLNA TSEMIPVTWP EFSNIHPFAP
560 570 580 590 600
LDQTVGYREM IDQLEAMLCA ATGYAAVSLQ PNAGSQGEYA GLLIIHAYHA
610 620 630 640 650
SRGESHRDIC LIPSSAHGTN PASAQMAGMK VVVVACDENG NVDLADLAKK
660 670 680 690 700
AEQHSKNLAA IMITYPSTHG VFEQGVQQIC DIVHKHGGQV YVDGANMNAM
710 720 730 740 750
VGVAAPGQFG GDVSHLNLHK TFCIPHGGGG PGVGPVAVGA HLADFLPNQD
760 770 780 790 800
SVGYRRDENG IGGVSAAPFG SASILPISWM YIAMMGSAGL TAATENAILT
810 820 830 840 850
ANYVARRLSP HFPVLYTGQH GLVAHECILD LRPLQKATGI SNEDVAKRLM
860 870 880 890 900
DYGFHAPTMS FPVPGTLMIE PTESEALHEL DRFIDAMIAI RGEIARVEDG
910 920 930 940 950
SFDREDNPLK HAPHTAAVVV SDKWNHKYTR EEAAYPVASL RTQKYWPPVG
960 970
RADNVYGDRN LFCSCVPLSE YAED
Length:974
Mass (Da):104,819
Last modified:May 30, 2006 - v1
Checksum:iF79B97D16F9279DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA. Translation: ABF10354.1.
RefSeqiWP_011517911.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF10354; ABF10354; Rmet_3482.
GeneIDi24151102.
KEGGirme:Rmet_3482.
PATRICi20291641. VBIRalMet4734_3878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000352 Genomic DNA. Translation: ABF10354.1.
RefSeqiWP_011517911.1. NC_007973.1.

3D structure databases

ProteinModelPortaliQ1LHM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266264.Rmet_3482.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF10354; ABF10354; Rmet_3482.
GeneIDi24151102.
KEGGirme:Rmet_3482.
PATRICi20291641. VBIRalMet4734_3878.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-3729-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH34 / ATCC 43123 / DSM 2839.

Entry informationi

Entry nameiGCSP_RALME
AccessioniPrimary (citable) accession number: Q1LHM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: July 22, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.