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Q1LHM2

- GCSP_RALME

UniProt

Q1LHM2 - GCSP_RALME

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCMET266264:GJ5G-3729-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Rmet_3482
    OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
    Taxonomic identifieri266264 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 974974Glycine dehydrogenase (decarboxylating)PRO_1000045598Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei720 – 7201N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi266264.Rmet_3482.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1LHM2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1LHM2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAPLPMNAA AQGARPTLAE LEARDAFAAR HIGPDSAEQQ HMLKVLGFES    50
    RAALIDAVVP AAIRRRDGMS LGEFTAPLTE EAALGRLRAL AGKNRVLKSF 100
    IGQGYYNTLT PGVILRNIFE NPAWYTAYTP YQPEISQGRL EAMLNFQQMI 150
    TDLTGLDIAN ASMLDEGTAA AEAMTLLQRV NKHASNTFYV AEDVLPQTLE 200
    VVRTRALPLG IEVKVGPAAD AAQAHAFGVL LQYPGVNGDV ADYRAIAEAV 250
    HASGGRVVAA ADLLALTLIA APGEWGADVT VGNSQRFGVP LGFGGPHAGY 300
    MAVKDEFKRS MPGRLVGVTI DAQGNKAYRL ALQTREQHIR REKATSNICT 350
    AQVLLAVMAS MYAVYHGPQG LKRIAQRVHR LTATLAAGLK TLGHTPLNAT 400
    FFDTLTLETG FNTDAFHASA TARGINLRHV DATRIGISFD ETASRDDVIA 450
    LWEIFAHGKA VPDFDTIEAS VQDGFPATLA RQSAYLTHPV FNTHHAEHEM 500
    LRYLRALADK DLALDRTMIP LGSCTMKLNA TSEMIPVTWP EFSNIHPFAP 550
    LDQTVGYREM IDQLEAMLCA ATGYAAVSLQ PNAGSQGEYA GLLIIHAYHA 600
    SRGESHRDIC LIPSSAHGTN PASAQMAGMK VVVVACDENG NVDLADLAKK 650
    AEQHSKNLAA IMITYPSTHG VFEQGVQQIC DIVHKHGGQV YVDGANMNAM 700
    VGVAAPGQFG GDVSHLNLHK TFCIPHGGGG PGVGPVAVGA HLADFLPNQD 750
    SVGYRRDENG IGGVSAAPFG SASILPISWM YIAMMGSAGL TAATENAILT 800
    ANYVARRLSP HFPVLYTGQH GLVAHECILD LRPLQKATGI SNEDVAKRLM 850
    DYGFHAPTMS FPVPGTLMIE PTESEALHEL DRFIDAMIAI RGEIARVEDG 900
    SFDREDNPLK HAPHTAAVVV SDKWNHKYTR EEAAYPVASL RTQKYWPPVG 950
    RADNVYGDRN LFCSCVPLSE YAED 974
    Length:974
    Mass (Da):104,819
    Last modified:May 30, 2006 - v1
    Checksum:iF79B97D16F9279DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000352 Genomic DNA. Translation: ABF10354.1.
    RefSeqiWP_011517911.1. NC_007973.1.
    YP_585623.1. NC_007973.1.

    Genome annotation databases

    EnsemblBacteriaiABF10354; ABF10354; Rmet_3482.
    GeneIDi4040330.
    KEGGirme:Rmet_3482.
    PATRICi20291641. VBIRalMet4734_3878.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000352 Genomic DNA. Translation: ABF10354.1 .
    RefSeqi WP_011517911.1. NC_007973.1.
    YP_585623.1. NC_007973.1.

    3D structure databases

    ProteinModelPortali Q1LHM2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266264.Rmet_3482.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF10354 ; ABF10354 ; Rmet_3482 .
    GeneIDi 4040330.
    KEGGi rme:Rmet_3482.
    PATRICi 20291641. VBIRalMet4734_3878.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci CMET266264:GJ5G-3729-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH34 / ATCC 43123 / DSM 2839.

    Entry informationi

    Entry nameiGCSP_RALME
    AccessioniPrimary (citable) accession number: Q1LHM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3