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Q1LHM2

- GCSP_RALME

UniProt

Q1LHM2 - GCSP_RALME

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-3729-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Rmet_3482
OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 974974Glycine dehydrogenase (decarboxylating)PRO_1000045598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei720 – 7201N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi266264.Rmet_3482.

Structurei

3D structure databases

ProteinModelPortaliQ1LHM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LHM2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAPLPMNAA AQGARPTLAE LEARDAFAAR HIGPDSAEQQ HMLKVLGFES
60 70 80 90 100
RAALIDAVVP AAIRRRDGMS LGEFTAPLTE EAALGRLRAL AGKNRVLKSF
110 120 130 140 150
IGQGYYNTLT PGVILRNIFE NPAWYTAYTP YQPEISQGRL EAMLNFQQMI
160 170 180 190 200
TDLTGLDIAN ASMLDEGTAA AEAMTLLQRV NKHASNTFYV AEDVLPQTLE
210 220 230 240 250
VVRTRALPLG IEVKVGPAAD AAQAHAFGVL LQYPGVNGDV ADYRAIAEAV
260 270 280 290 300
HASGGRVVAA ADLLALTLIA APGEWGADVT VGNSQRFGVP LGFGGPHAGY
310 320 330 340 350
MAVKDEFKRS MPGRLVGVTI DAQGNKAYRL ALQTREQHIR REKATSNICT
360 370 380 390 400
AQVLLAVMAS MYAVYHGPQG LKRIAQRVHR LTATLAAGLK TLGHTPLNAT
410 420 430 440 450
FFDTLTLETG FNTDAFHASA TARGINLRHV DATRIGISFD ETASRDDVIA
460 470 480 490 500
LWEIFAHGKA VPDFDTIEAS VQDGFPATLA RQSAYLTHPV FNTHHAEHEM
510 520 530 540 550
LRYLRALADK DLALDRTMIP LGSCTMKLNA TSEMIPVTWP EFSNIHPFAP
560 570 580 590 600
LDQTVGYREM IDQLEAMLCA ATGYAAVSLQ PNAGSQGEYA GLLIIHAYHA
610 620 630 640 650
SRGESHRDIC LIPSSAHGTN PASAQMAGMK VVVVACDENG NVDLADLAKK
660 670 680 690 700
AEQHSKNLAA IMITYPSTHG VFEQGVQQIC DIVHKHGGQV YVDGANMNAM
710 720 730 740 750
VGVAAPGQFG GDVSHLNLHK TFCIPHGGGG PGVGPVAVGA HLADFLPNQD
760 770 780 790 800
SVGYRRDENG IGGVSAAPFG SASILPISWM YIAMMGSAGL TAATENAILT
810 820 830 840 850
ANYVARRLSP HFPVLYTGQH GLVAHECILD LRPLQKATGI SNEDVAKRLM
860 870 880 890 900
DYGFHAPTMS FPVPGTLMIE PTESEALHEL DRFIDAMIAI RGEIARVEDG
910 920 930 940 950
SFDREDNPLK HAPHTAAVVV SDKWNHKYTR EEAAYPVASL RTQKYWPPVG
960 970
RADNVYGDRN LFCSCVPLSE YAED
Length:974
Mass (Da):104,819
Last modified:May 30, 2006 - v1
Checksum:iF79B97D16F9279DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF10354.1.
RefSeqiYP_585623.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF10354; ABF10354; Rmet_3482.
GeneIDi4040330.
KEGGirme:Rmet_3482.
PATRICi20291641. VBIRalMet4734_3878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000352 Genomic DNA. Translation: ABF10354.1 .
RefSeqi YP_585623.1. NC_007973.1.

3D structure databases

ProteinModelPortali Q1LHM2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266264.Rmet_3482.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF10354 ; ABF10354 ; Rmet_3482 .
GeneIDi 4040330.
KEGGi rme:Rmet_3482.
PATRICi 20291641. VBIRalMet4734_3878.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CMET266264:GJ5G-3729-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH34 / ATCC 43123 / DSM 2839.

Entry informationi

Entry nameiGCSP_RALME
AccessioniPrimary (citable) accession number: Q1LHM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3