Q1LEK7 (Q1LEK7_RALME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 3 HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase 3 HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 3 HAMAP MF_01401

Gene names

Name:	msrA EMBL ABF11419.1
Synonyms:	msrA3 HAMAP MF_01401
Ordered Locus Names:	Rmet_4557

Encoded on

Plasmid megaplasmid CH34

Organism

Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) [Complete proteome] [HAMAP]

Taxonomic identifier

266264 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP MF_01401 SAAS SAAS002569 EMBL ABF11419.1
Technical term	Complete proteome Plasmid EMBL ABF11419.1
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	14	1	By similarity HAMAP MF_01401

Sequences

	Sequence		Length	Mass (Da)
	Q1LEK7 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: BA4C59128860D15C	FASTA	168	18,955
	10 20 30 40 50 60 MTTQIETAIL AGGCFWGMQD LLRRYPGVLS TRVGYTGGDV PNATYRHHGT HAEGIEIAFD 70 80 90 100 110 120 PSQISYRQIL EFFFQIHDPT TKNRQGNDVG TSYRSAIFYL NDEQKQTAED TVADVNASGL 130 140 150 160 WPGKVVTEIA PAGPFWDAEP EHQDYLERYP NGYTCHFIRP GWKLPKRG

References

[1]

"Complete sequence of the megaplasmid of Ralstonia metallidurans CH34." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Martinez M., Goltsman E., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Mergeay M., Benotmane M.A., Vallaeys T., Michaux A., Monchy S., Dunn J., McCorkle S., Taghavi S., van der Lelie D., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CH34 / ATCC 43123 / DSM 2839.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000353 Genomic DNA. Translation: ABF11419.1.
RefSeq	YP_586688.1. NC_007974.2.
3D structure databases
ProteinModelPortal	Q1LEK7.
SMR	Q1LEK7. Positions 3-167.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LEK7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4041416.
GenomeReviews	Gene locus Rmet_4557 in contig CP000353_GR.
KEGG	rme:Rmet_4557.
PATRIC	20293862. VBIRalMet4734_4975.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	YRQILEF.
PhylomeDB	Q1LEK7.
ProtClustDB	PRK14054.
Enzyme and pathway databases
BioCyc	RMET266264:RMET_4557-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q1LEK7_RALME

Accession

Primary (citable) accession number: Q1LEK7

Entry history

Integrated into UniProtKB/TrEMBL:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)