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Q1LCQ9

- ACDH2_RALME

UniProt

Q1LCQ9 - ACDH2_RALME

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Protein

Acetaldehyde dehydrogenase 2

Gene

Rmet_5208

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Acyl-thioester intermediateUniRule annotation
Binding sitei285 – 2851NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NADUniRule annotation
Nucleotide bindingi160 – 1689NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-5703-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:Rmet_5208
Encoded oniPlasmid megaplasmid CH340 Publication
OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002429: Plasmid megaplasmid CH34

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Acetaldehyde dehydrogenase 2PRO_0000387715Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266264.Rmet_5208.

Structurei

3D structure databases

ProteinModelPortaliQ1LCQ9.
SMRiQ1LCQ9. Positions 5-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiIPEDADH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LCQ9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPCKVAIIG SGNIGTDLMI KILRHGKHVE MGAMVGIDPT SEGLARATRL
60 70 80 90 100
GVPVTAAGID GLLAMPEFGE IRIAFDATSA GAHARHNATL QAHNVRVIDL
110 120 130 140 150
TPAAIGPYVV PSVNAGEHLD APNLNMVTCG GQATIPIVAA VASVTPVHYA
160 170 180 190 200
EIVASIASKS AGPGTRDNID EFTETTSRAI ESVGGARRGK AIIVLNPAEP
210 220 230 240 250
PLIMRDTVCC LIDEADTAAI EAAVHAMVER MQGYVPGYRL KQRVQFDRID
260 270 280 290 300
TPVNVPGLGP TTGLKVTVFL EVEGAAHYLP AYAGNLDIMT SAALACAERV
310
AQALGNHHAL SAAS
Length:314
Mass (Da):32,613
Last modified:May 30, 2006 - v1
Checksum:i074C27219B578DB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000353 Genomic DNA. Translation: ABF12067.1.
RefSeqiWP_011519613.1. NC_007974.2.
YP_587336.1. NC_007974.2.

Genome annotation databases

EnsemblBacteriaiABF12067; ABF12067; Rmet_5208.
GeneIDi4042069.
KEGGirme:Rmet_5208.
PATRICi20295176. VBIRalMet4734_5630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000353 Genomic DNA. Translation: ABF12067.1 .
RefSeqi WP_011519613.1. NC_007974.2.
YP_587336.1. NC_007974.2.

3D structure databases

ProteinModelPortali Q1LCQ9.
SMRi Q1LCQ9. Positions 5-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266264.Rmet_5208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF12067 ; ABF12067 ; Rmet_5208 .
GeneIDi 4042069.
KEGGi rme:Rmet_5208.
PATRICi 20295176. VBIRalMet4734_5630.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi IPEDADH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci CMET266264:GJ5G-5703-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH34 / ATCC 43123 / DSM 2839.

Entry informationi

Entry nameiACDH2_RALME
AccessioniPrimary (citable) accession number: Q1LCQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3