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Protein

Transcriptional coactivator YAP1

Gene

yap1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1 (PubMed:21687713). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (PubMed:25778702).By similarity1 Publication

GO - Biological processi

  • blood vessel morphogenesis Source: ZFIN
  • brain development Source: ZFIN
  • cartilage development Source: ZFIN
  • cilium assembly Source: ZFIN
  • dorsal/ventral axis specification Source: CACAO
  • embryonic hemopoiesis Source: CACAO
  • endoderm development Source: ZFIN
  • fin regeneration Source: ZFIN
  • heart formation Source: CACAO
  • negative regulation of apoptotic process Source: CACAO
  • negative regulation of gene expression Source: CACAO
  • pancreas development Source: ZFIN
  • positive regulation of glutamate-ammonia ligase activity Source: ZFIN
  • posterior lateral line development Source: ZFIN
  • pronephric duct development Source: ZFIN
  • regulation of organ growth Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • retinal pigment epithelium development Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DRE-1251985 Nuclear signaling by ERBB4
R-DRE-2028269 Signaling by Hippo
R-DRE-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-DRE-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-DRE-8951671 RUNX3 regulates YAP1-mediated transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional coactivator YAP1
Short name:
Yes-associated protein 1
Short name:
zYAP1 Publication
Alternative name(s):
Protein yorkie homolog
Yes-associated protein YAP65 homolog
Gene namesi
Name:yap1
ORF Names:CH211-181P1.5-001Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-030131-9710 yap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryos display a small head with smaller eyes than normal and fewer cartilages in the branchial arches. Marked increase in cell death in brain (PubMed:19393221). Incomplete epiboly at gastrulation, characterized by blastopore closure defects and impaired axis formation (PubMed:21687713).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004339051 – 442Transcriptional coactivator YAP1Add BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Phosphoserine; by LATS1 and LATS2By similarity1
Modified residuei69Phosphoserine; by LATS1 and LATS2By similarity1
Modified residuei87Phosphoserine; by LATS1 and LATS2By similarity1
Modified residuei119Phosphoserine; by LATS1 and LATS2By similarity1

Post-translational modificationi

Phosphorylated by lats1 and lats2; leading to cytoplasmic translocation and inactivation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ1L8J7
PRIDEiQ1L8J7

PTM databases

iPTMnetiQ1L8J7

Expressioni

Tissue specificityi

Expressed in the notochord, brain, eyes, branchial arches and pectoral fins.1 Publication

Developmental stagei

Maternally expressed in the embryo: maternal expression is ubiquitous.1 Publication

Gene expression databases

BgeeiENSDARG00000068401

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000089684

Structurei

3D structure databases

ProteinModelPortaliQ1L8J7
SMRiQ1L8J7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 159WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini186 – 219WW 2PROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni247 – 442Transactivation domainBy similarityAdd BLAST196

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili258 – 279Sequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the YAP1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00510000046760
HOGENOMiHOG000007854
HOVERGENiHBG002748
KOiK16687
OMAiDQTTTWQ
OrthoDBiEOG091G095A
PhylomeDBiQ1L8J7
TreeFamiTF326941

Family and domain databases

CDDicd00201 WW, 2 hits
InterProiView protein in InterPro
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00397 WW, 2 hits
SMARTiView protein in SMART
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q1L8J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNQHNPPA GHQIVHVRGD SETDLEALFN AVMNPKNTIV PPSVPMRLRK
60 70 80 90 100
LPDSFFTPPE PKSHSRQAST DAGTAGTVTP HHVRAHSSPA SLQLGAVSPG
110 120 130 140 150
ALTSMGPANA PPQHLRQSSY EIPDDMPLPP GWEMAKTPSG QRYFLNHNDQ
160 170 180 190 200
TTTWQDPRKA LLQMNQAAPA SPVPVQQQNI MNPASGPLPD GWEQAITSEG
210 220 230 240 250
EIYYINHKNK TTSWLDPRLD PRFAMNQQRI SQSAPVKQGS QLPSSPQSGV
260 270 280 290 300
MSGNNPIRLQ QIHIEKERLR IKQELLRQRP QELALRNQLP TSMEQDGGTQ
310 320 330 340 350
NPVSSPGMGQ DARNMTTNSS DPFLNSGTYH SRDESTDSGL SMSSYSVPRT
360 370 380 390 400
PDDFLNSVDE METGDTLGPG SMATQPSRFP DYLDAIPGTD VDLGTLEGES
410 420 430 440
MAVEGEELMP SLQEALSSDI LNDMESVLAA TKIDKENFLT WL
Length:442
Mass (Da):48,362
Last modified:July 10, 2007 - v2
Checksum:iF1B0FC36035C535C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti370G → S in AAI29217 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762425, CT573116 Genomic DNA Translation: CAK04259.2
BC129216 mRNA Translation: AAI29217.1
RefSeqiNP_001132952.1, NM_001139480.1
UniGeneiDr.119226
Dr.75317

Genome annotation databases

EnsembliENSDART00000098914; ENSDARP00000089684; ENSDARG00000068401
GeneIDi561411
KEGGidre:561411

Similar proteinsi

Entry informationi

Entry nameiYAP1_DANRE
AccessioniPrimary (citable) accession number: Q1L8J7
Secondary accession number(s): A1L1U5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 16, 2015
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health