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Protein

Transcriptional coactivator YAP1

Gene

yap1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1 (PubMed:21687713). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (PubMed:25778702).By similarity1 Publication

GO - Biological processi

  • dorsal/ventral axis specification Source: CACAO
  • embryonic hemopoiesis Source: CACAO
  • heart formation Source: CACAO
  • negative regulation of apoptotic process Source: CACAO
  • negative regulation of gene expression Source: CACAO
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DRE-1251985. Nuclear signaling by ERBB4.
R-DRE-2028269. Signaling by Hippo.
R-DRE-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional coactivator YAP1
Short name:
Yes-associated protein 1
Short name:
zYAP1 Publication
Alternative name(s):
Protein yorkie homolog
Yes-associated protein YAP65 homolog
Gene namesi
Name:yap1
ORF Names:CH211-181P1.5-001Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryos display a small head with smaller eyes than normal and fewer cartilages in the branchial arches. Marked increase in cell death in brain (PubMed:19393221). Incomplete epiboly at gastrulation, characterized by blastopore closure defects and impaired axis formation (PubMed:21687713).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Transcriptional coactivator YAP1PRO_0000433905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Phosphoserine; by LATS1 and LATS2By similarity
Modified residuei69 – 691Phosphoserine; by LATS1 and LATS2By similarity
Modified residuei87 – 871Phosphoserine; by LATS1 and LATS2By similarity
Modified residuei119 – 1191Phosphoserine; by LATS1 and LATS2By similarity

Post-translational modificationi

Phosphorylated by lats1 and lats2; leading to cytoplasmic translocation and inactivation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ1L8J7.

Expressioni

Tissue specificityi

Expressed in the notochord, brain, eyes, branchial arches and pectoral fins.1 Publication

Developmental stagei

Maternally expressed in the embryo: maternal expression is ubiquitous.1 Publication

Gene expression databases

BgeeiENSDARG00000068401.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000089684.

Structurei

3D structure databases

ProteinModelPortaliQ1L8J7.
SMRiQ1L8J7. Positions 120-162, 184-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 15934WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini186 – 21934WW 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni247 – 442196Transactivation domainBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili258 – 27922Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the YAP1 family.Curated
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00510000046760.
HOGENOMiHOG000007854.
HOVERGENiHBG002748.
KOiK16687.
OMAiMDPGQQP.
OrthoDBiEOG091G095A.
PhylomeDBiQ1L8J7.
TreeFamiTF326941.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1L8J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNQHNPPA GHQIVHVRGD SETDLEALFN AVMNPKNTIV PPSVPMRLRK
60 70 80 90 100
LPDSFFTPPE PKSHSRQAST DAGTAGTVTP HHVRAHSSPA SLQLGAVSPG
110 120 130 140 150
ALTSMGPANA PPQHLRQSSY EIPDDMPLPP GWEMAKTPSG QRYFLNHNDQ
160 170 180 190 200
TTTWQDPRKA LLQMNQAAPA SPVPVQQQNI MNPASGPLPD GWEQAITSEG
210 220 230 240 250
EIYYINHKNK TTSWLDPRLD PRFAMNQQRI SQSAPVKQGS QLPSSPQSGV
260 270 280 290 300
MSGNNPIRLQ QIHIEKERLR IKQELLRQRP QELALRNQLP TSMEQDGGTQ
310 320 330 340 350
NPVSSPGMGQ DARNMTTNSS DPFLNSGTYH SRDESTDSGL SMSSYSVPRT
360 370 380 390 400
PDDFLNSVDE METGDTLGPG SMATQPSRFP DYLDAIPGTD VDLGTLEGES
410 420 430 440
MAVEGEELMP SLQEALSSDI LNDMESVLAA TKIDKENFLT WL
Length:442
Mass (Da):48,362
Last modified:July 10, 2007 - v2
Checksum:iF1B0FC36035C535C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti370 – 3701G → S in AAI29217 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762425, CT573116 Genomic DNA. Translation: CAK04259.2.
BC129216 mRNA. Translation: AAI29217.1.
RefSeqiNP_001132952.1. NM_001139480.1.
UniGeneiDr.119226.
Dr.75317.

Genome annotation databases

EnsembliENSDART00000098914; ENSDARP00000089684; ENSDARG00000068401.
GeneIDi561411.
KEGGidre:561411.

Cross-referencesi

Web resourcesi

Protein Spotlight

Shaping life - Issue 175 of January 2016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762425, CT573116 Genomic DNA. Translation: CAK04259.2.
BC129216 mRNA. Translation: AAI29217.1.
RefSeqiNP_001132952.1. NM_001139480.1.
UniGeneiDr.119226.
Dr.75317.

3D structure databases

ProteinModelPortaliQ1L8J7.
SMRiQ1L8J7. Positions 120-162, 184-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000089684.

Proteomic databases

PaxDbiQ1L8J7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000098914; ENSDARP00000089684; ENSDARG00000068401.
GeneIDi561411.
KEGGidre:561411.

Organism-specific databases

CTDi10413.

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00510000046760.
HOGENOMiHOG000007854.
HOVERGENiHBG002748.
KOiK16687.
OMAiMDPGQQP.
OrthoDBiEOG091G095A.
PhylomeDBiQ1L8J7.
TreeFamiTF326941.

Enzyme and pathway databases

ReactomeiR-DRE-1251985. Nuclear signaling by ERBB4.
R-DRE-2028269. Signaling by Hippo.
R-DRE-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

Miscellaneous databases

PROiQ1L8J7.

Gene expression databases

BgeeiENSDARG00000068401.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYAP1_DANRE
AccessioniPrimary (citable) accession number: Q1L8J7
Secondary accession number(s): A1L1U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 16, 2015
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.