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Protein

Alpha-conotoxin PeIA

Gene
N/A
Organism
Conus pergrandis (Grand cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This synthetic peptide potently and reversibly blocks alpha-9/alpha-10 nAChR (IC50=6.9 nM) and alpha-3/beta-2 (IC50=23 nM). This synthetic toxin also inhibits N-type calcium channels (Ca2.2/CACNA1B) (IC50=1.1 nM) via the activation of the G protein-coupled GABA(B) receptor in DRG neurons.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acetylcholine receptor inhibiting toxin, Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin PeIA
OrganismiConus pergrandis (Grand cone)
Taxonomic identifieri330676 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri5. PeIA precursor.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei‹1 – 21›21By similarityPRO_0000247850Add
BLAST
Peptidei22 – 3716Alpha-conotoxin PeIAPRO_0000247851Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 29By similarity
Disulfide bondi24 ↔ 37By similarity
Modified residuei37 – 371Cysteine amideBy similarity

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

Secondary structure

1
38
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi23 – 253Combined sources
Helixi27 – 304Combined sources
Turni34 – 363Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5JMEX-ray2.34F/G/H/I22-37[»]
ProteinModelPortaliQ1L777.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiIPR009958. Conotoxin_a-typ.
[Graphical view]
PfamiPF07365. Toxin_8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1L777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
FDGRNAAAND KASDLVALTV RGCCSHPACS VNHPELCG
Length:38
Mass (Da):3,900
Last modified:May 30, 2006 - v1
Checksum:iAE40EFB659EB0EFC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ008450 Genomic DNA. Translation: AAY57814.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ008450 Genomic DNA. Translation: AAY57814.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5JMEX-ray2.34F/G/H/I22-37[»]
ProteinModelPortaliQ1L777.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri5. PeIA precursor.

Family and domain databases

InterProiIPR009958. Conotoxin_a-typ.
[Graphical view]
PfamiPF07365. Toxin_8. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCA1A_CONPR
AccessioniPrimary (citable) accession number: Q1L777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 30, 2006
Last modified: September 7, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.