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Protein

Prostate-associated microseminoprotein

Gene

MSMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate-associated microseminoprotein
Alternative name(s):
PC3-secreted microprotein
Gene namesi
Name:MSMP
Synonyms:PSMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:29663. MSMP.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723190.

Polymorphism and mutation databases

BioMutaiMSMP.
DMDMi121946765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 139104Prostate-associated microseminoproteinPRO_0000338648Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 78By similarity
Disulfide bondi46 ↔ 69By similarity
Disulfide bondi64 ↔ 100By similarity
Disulfide bondi67 ↔ 77By similarity
Disulfide bondi91 ↔ 114By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ1L6U9.
PaxDbiQ1L6U9.
PeptideAtlasiQ1L6U9.
PRIDEiQ1L6U9.
TopDownProteomicsiQ1L6U9.

PTM databases

iPTMnetiQ1L6U9.
PhosphoSiteiQ1L6U9.

Expressioni

Tissue specificityi

Detected in prostate epithelium (at protein level). Detected in trachea and testis. Highly expressed in the human prostate cancer cell line PC-3.1 Publication

Gene expression databases

BgeeiQ1L6U9.

Organism-specific databases

HPAiHPA055174.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000419194.

Structurei

3D structure databases

ProteinModelPortaliQ1L6U9.
SMRiQ1L6U9. Positions 37-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-microseminoprotein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWMX. Eukaryota.
ENOG410Y5U1. LUCA.
GeneTreeiENSGT00400000024910.
HOGENOMiHOG000113669.
InParanoidiQ1L6U9.
OMAiHSKCYFQ.
OrthoDBiEOG7S4X80.
PhylomeDBiQ1L6U9.
TreeFamiTF338336.

Family and domain databases

InterProiIPR008735. PSP94.
[Graphical view]
PANTHERiPTHR10500. PTHR10500. 1 hit.
PfamiPF05825. PSP94. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1L6U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRMLWAGQ AKGILGGWGI ICLVMSLLLQ HPGVYSKCYF QAQAPCHYEG
60 70 80 90 100
KYFTLGESWL RKDCFHCTCL HPVGVGCCDT SQHPIDFPAG CEVRQEAGTC
110 120 130
QFSLVQKSDP RLPCKGGGPD PEWGSANTPV PGAPAPHSS
Length:139
Mass (Da):14,993
Last modified:May 30, 2006 - v1
Checksum:iED4C9691F0B05E3B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161G → V.
Corresponds to variant rs3750436 [ dbSNP | Ensembl ].
VAR_043818

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012170 mRNA. Translation: AAY68208.1.
AL133410 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58344.1.
CCDSiCCDS43797.1.
RefSeqiNP_001037729.1. NM_001044264.2.
UniGeneiHs.571601.

Genome annotation databases

EnsembliENST00000436428; ENSP00000419194; ENSG00000215183.
GeneIDi692094.
KEGGihsa:692094.
UCSCiuc003zyb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012170 mRNA. Translation: AAY68208.1.
AL133410 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58344.1.
CCDSiCCDS43797.1.
RefSeqiNP_001037729.1. NM_001044264.2.
UniGeneiHs.571601.

3D structure databases

ProteinModelPortaliQ1L6U9.
SMRiQ1L6U9. Positions 37-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000419194.

PTM databases

iPTMnetiQ1L6U9.
PhosphoSiteiQ1L6U9.

Polymorphism and mutation databases

BioMutaiMSMP.
DMDMi121946765.

Proteomic databases

MaxQBiQ1L6U9.
PaxDbiQ1L6U9.
PeptideAtlasiQ1L6U9.
PRIDEiQ1L6U9.
TopDownProteomicsiQ1L6U9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436428; ENSP00000419194; ENSG00000215183.
GeneIDi692094.
KEGGihsa:692094.
UCSCiuc003zyb.3. human.

Organism-specific databases

CTDi692094.
GeneCardsiMSMP.
HGNCiHGNC:29663. MSMP.
HPAiHPA055174.
MIMi612191. gene.
neXtProtiNX_Q1L6U9.
PharmGKBiPA164723190.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWMX. Eukaryota.
ENOG410Y5U1. LUCA.
GeneTreeiENSGT00400000024910.
HOGENOMiHOG000113669.
InParanoidiQ1L6U9.
OMAiHSKCYFQ.
OrthoDBiEOG7S4X80.
PhylomeDBiQ1L6U9.
TreeFamiTF338336.

Miscellaneous databases

ChiTaRSiMSMP. human.
GenomeRNAii692094.
NextBioi124432.
PROiQ1L6U9.
SOURCEiSearch...

Gene expression databases

BgeeiQ1L6U9.

Family and domain databases

InterProiIPR008735. PSP94.
[Graphical view]
PANTHERiPTHR10500. PTHR10500. 1 hit.
PfamiPF05825. PSP94. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissue."
    Valtonen-Andre C., Bjartell A., Hellsten R., Lilja H., Haerkoenen P., Lundwall A.
    Biol. Chem. 388:289-295(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Prostate.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMSMP_HUMAN
AccessioniPrimary (citable) accession number: Q1L6U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 30, 2006
Last modified: March 16, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.