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Q1L5Z9 (LONF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LON peptidase N-terminal domain and RING finger protein 2
Alternative name(s):
Neuroblastoma apoptosis-related protease
RING finger protein 192
Gene names
Name:LONRF2
Synonyms:RNF192
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length754 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 Lon domain.

Contains 1 RING-type zinc finger.

Contains 6 TPR repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
TPR repeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP-dependent peptidase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q1L5Z9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q1L5Z9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 754754LON peptidase N-terminal domain and RING finger protein 2
PRO_0000277670

Regions

Repeat23 – 5836TPR 1
Repeat59 – 9133TPR 2
Repeat197 – 23034TPR 3
Repeat231 – 26434TPR 4
Repeat266 – 29833TPR 5
Repeat447 – 48337TPR 6
Domain530 – 738209Lon
Zinc finger449 – 48739RING-type
Compositional bias3 – 1210Poly-Pro

Natural variations

Alternative sequence1 – 243243Missing in isoform 2.
VSP_023079
Natural variant1831L → P.
Corresponds to variant rs4851287 [ dbSNP | Ensembl ].
VAR_030590
Natural variant4261L → P. Ref.1 Ref.2 Ref.4
Corresponds to variant rs4851287 [ dbSNP | Ensembl ].
VAR_054639
Natural variant5621R → W in a colorectal cancer sample; somatic mutation. Ref.5
VAR_035953

Experimental info

Sequence conflict6481E → Q in AAY84832. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: 688EE74DCF7893D3

FASTA75483,654
        10         20         30         40         50         60 
MSPEPVPPPP PPQCPGCDRA EPIAQRLEEG DEAFRAGDYE MAAELFRSML AGLAQPDRGL 

        70         80         90        100        110        120 
CLRLGDALAR AGRLPEALGA FRGAARLGAL RPEELEELAG GLVRAVGLRD RPLSAENPGG 

       130        140        150        160        170        180 
EPEAPGEGGP APEPRAPRDL LGCPRCRRLL HKPVTLPCGL TVCKRCVEPG PARPQVRRVN 

       190        200        210        220        230        240 
VVLSGLLEKC FPAECRLRRL AGQARSLQRQ QQPEAALLRC DQALELAPDD NSLLLLRAEL 

       250        260        270        280        290        300 
YLTMKNYEQA LQDASAACQN EPLLIKGHQV KAQALSGLGR SKEVLKEFLY CLALNPECNS 

       310        320        330        340        350        360 
VKKEAQKVMC EVLFSATANV HENLTSSIQS RLKAQGHSHM NAQALLEEGD AGSSENSSEK 

       370        380        390        400        410        420 
SDMLGNTNSS VLYFILGLHF EEDKKALESI LPTAPSAGLK RQFPDDVEDA PDLNAPGKIP 

       430        440        450        460        470        480 
KKDLSLQRSP NSETEESQGL SLDVTDFECA LCMRLLFEPV TTPCGHTFCL KCLERCLDHA 

       490        500        510        520        530        540 
PHCPLCKDKL SELLASRNFN ITVLAEELIF RYLPDELSDR KRIYDEEMSE LSNLTRDVPI 

       550        560        570        580        590        600 
FVCAMAFPTV PCPLHVFEPR YRLMIRRCME TGTKRFGMCL SAEHAGLSEY GCMLEIKDVR 

       610        620        630        640        650        660 
TFPDGSSVVD AIGISRFRVL SHRHRDGYNT ADIEYLEDEK VEGPEYEELA ALHDSVHQQS 

       670        680        690        700        710        720 
VSWFASLQDR MKEQILSHFG VMPDREPEPQ SNPSGPAWSW WILAVLPLER KAQLAILGMT 

       730        740        750 
SLKERLLAIR RILVIITRKM NSRQELANAR ERNN 

« Hide

Isoform 2 [UniParc].

Checksum: AE7D01250CE317F9
Show »

FASTA51157,487

References

« Hide 'large scale' references
[1]"Differential screening of novel gene in apoptotic neuronal cells and its functional study during embryonic development."
Choi D.K.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-426.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-426.
Tissue: Hippocampus.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-426.
Tissue: Brain.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-562.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ020495 mRNA. Translation: AAY84832.1.
AK127206 mRNA. Translation: BAC86883.1.
AC104782 Genomic DNA. No translation available.
AC012493 Genomic DNA. No translation available.
BC101664 mRNA. Translation: AAI01665.1.
BC101662 mRNA. Translation: AAI01663.1.
RefSeqNP_940863.3. NM_198461.3.
UniGeneHs.21380.

3D structure databases

ProteinModelPortalQ1L5Z9.
SMRQ1L5Z9. Positions 23-102, 195-308, 447-509, 537-636.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127903. 2 interactions.
IntActQ1L5Z9. 1 interaction.
STRING9606.ENSP00000377086.

PTM databases

PhosphoSiteQ1L5Z9.

Polymorphism databases

DMDM313104224.

Proteomic databases

PaxDbQ1L5Z9.
PRIDEQ1L5Z9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000393437; ENSP00000377086; ENSG00000170500. [Q1L5Z9-1]
ENST00000409647; ENSP00000386823; ENSG00000170500. [Q1L5Z9-2]
GeneID164832.
KEGGhsa:164832.
UCSCuc002tal.4. human. [Q1L5Z9-1]

Organism-specific databases

CTD164832.
GeneCardsGC02M100889.
H-InvDBHIX0024130.
HGNCHGNC:24788. LONRF2.
neXtProtNX_Q1L5Z9.
PharmGKBPA142671540.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2802.
HOGENOMHOG000060199.
HOVERGENHBG081924.
InParanoidQ1L5Z9.
OMAKVMCEVL.
OrthoDBEOG7S7SD6.
PhylomeDBQ1L5Z9.
TreeFamTF327043.

Gene expression databases

BgeeQ1L5Z9.
CleanExHS_LONRF2.
GenevestigatorQ1L5Z9.

Family and domain databases

Gene3D1.25.40.10. 2 hits.
3.30.40.10. 2 hits.
InterProIPR003111. Pept_S16_N.
IPR015947. PUA-like_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF02190. LON. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTSM00184. RING. 2 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMSSF88697. SSF88697. 1 hit.
PROSITEPS50293. TPR_REGION. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLONRF2. human.
GenomeRNAi164832.
NextBio88502.
PROQ1L5Z9.

Entry information

Entry nameLONF2_HUMAN
AccessionPrimary (citable) accession number: Q1L5Z9
Secondary accession number(s): B9A006, Q6ZSR4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM