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Q1L5Z9

- LONF2_HUMAN

UniProt

Q1L5Z9 - LONF2_HUMAN

Protein

LON peptidase N-terminal domain and RING finger protein 2

Gene

LONRF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri449 – 48739RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP-dependent peptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 2
    Alternative name(s):
    Neuroblastoma apoptosis-related protease
    RING finger protein 192
    Gene namesi
    Name:LONRF2
    Synonyms:RNF192
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:24788. LONRF2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671540.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 754754LON peptidase N-terminal domain and RING finger protein 2PRO_0000277670Add
    BLAST

    Proteomic databases

    MaxQBiQ1L5Z9.
    PaxDbiQ1L5Z9.
    PRIDEiQ1L5Z9.

    PTM databases

    PhosphoSiteiQ1L5Z9.

    Expressioni

    Gene expression databases

    BgeeiQ1L5Z9.
    CleanExiHS_LONRF2.
    GenevestigatoriQ1L5Z9.

    Interactioni

    Protein-protein interaction databases

    BioGridi127903. 2 interactions.
    IntActiQ1L5Z9. 1 interaction.
    STRINGi9606.ENSP00000377086.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1L5Z9.
    SMRiQ1L5Z9. Positions 59-102, 192-290, 447-509.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati23 – 5836TPR 1Add
    BLAST
    Repeati59 – 9133TPR 2Add
    BLAST
    Repeati197 – 23034TPR 3Add
    BLAST
    Repeati231 – 26434TPR 4Add
    BLAST
    Repeati266 – 29833TPR 5Add
    BLAST
    Repeati447 – 48337TPR 6Add
    BLAST
    Domaini530 – 738209LonAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 1210Poly-Pro

    Sequence similaritiesi

    Contains 1 Lon domain.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 6 TPR repeats.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri449 – 48739RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, TPR repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2802.
    HOGENOMiHOG000060199.
    HOVERGENiHBG081924.
    InParanoidiQ1L5Z9.
    OMAiKVMCEVL.
    OrthoDBiEOG7S7SD6.
    PhylomeDBiQ1L5Z9.
    TreeFamiTF327043.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    3.30.40.10. 2 hits.
    InterProiIPR003111. Pept_S16_N.
    IPR015947. PUA-like_domain.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF02190. LON. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 2 hits.
    SM00028. TPR. 3 hits.
    [Graphical view]
    SUPFAMiSSF88697. SSF88697. 1 hit.
    PROSITEiPS50293. TPR_REGION. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q1L5Z9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSPEPVPPPP PPQCPGCDRA EPIAQRLEEG DEAFRAGDYE MAAELFRSML    50
    AGLAQPDRGL CLRLGDALAR AGRLPEALGA FRGAARLGAL RPEELEELAG 100
    GLVRAVGLRD RPLSAENPGG EPEAPGEGGP APEPRAPRDL LGCPRCRRLL 150
    HKPVTLPCGL TVCKRCVEPG PARPQVRRVN VVLSGLLEKC FPAECRLRRL 200
    AGQARSLQRQ QQPEAALLRC DQALELAPDD NSLLLLRAEL YLTMKNYEQA 250
    LQDASAACQN EPLLIKGHQV KAQALSGLGR SKEVLKEFLY CLALNPECNS 300
    VKKEAQKVMC EVLFSATANV HENLTSSIQS RLKAQGHSHM NAQALLEEGD 350
    AGSSENSSEK SDMLGNTNSS VLYFILGLHF EEDKKALESI LPTAPSAGLK 400
    RQFPDDVEDA PDLNAPGKIP KKDLSLQRSP NSETEESQGL SLDVTDFECA 450
    LCMRLLFEPV TTPCGHTFCL KCLERCLDHA PHCPLCKDKL SELLASRNFN 500
    ITVLAEELIF RYLPDELSDR KRIYDEEMSE LSNLTRDVPI FVCAMAFPTV 550
    PCPLHVFEPR YRLMIRRCME TGTKRFGMCL SAEHAGLSEY GCMLEIKDVR 600
    TFPDGSSVVD AIGISRFRVL SHRHRDGYNT ADIEYLEDEK VEGPEYEELA 650
    ALHDSVHQQS VSWFASLQDR MKEQILSHFG VMPDREPEPQ SNPSGPAWSW 700
    WILAVLPLER KAQLAILGMT SLKERLLAIR RILVIITRKM NSRQELANAR 750
    ERNN 754
    Length:754
    Mass (Da):83,654
    Last modified:November 30, 2010 - v3
    Checksum:i688EE74DCF7893D3
    GO
    Isoform 2 (identifier: Q1L5Z9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-243: Missing.

    Show »
    Length:511
    Mass (Da):57,487
    Checksum:iAE7D01250CE317F9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti648 – 6481E → Q in AAY84832. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti183 – 1831L → P.
    Corresponds to variant rs4851287 [ dbSNP | Ensembl ].
    VAR_030590
    Natural varianti426 – 4261L → P.3 Publications
    Corresponds to variant rs4851287 [ dbSNP | Ensembl ].
    VAR_054639
    Natural varianti562 – 5621R → W in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035953

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 243243Missing in isoform 2. 2 PublicationsVSP_023079Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ020495 mRNA. Translation: AAY84832.1.
    AK127206 mRNA. Translation: BAC86883.1.
    AC104782 Genomic DNA. No translation available.
    AC012493 Genomic DNA. No translation available.
    BC101664 mRNA. Translation: AAI01665.1.
    BC101662 mRNA. Translation: AAI01663.1.
    CCDSiCCDS2046.2. [Q1L5Z9-1]
    RefSeqiNP_940863.3. NM_198461.3. [Q1L5Z9-1]
    UniGeneiHs.21380.

    Genome annotation databases

    EnsembliENST00000393437; ENSP00000377086; ENSG00000170500. [Q1L5Z9-1]
    ENST00000409647; ENSP00000386823; ENSG00000170500. [Q1L5Z9-2]
    GeneIDi164832.
    KEGGihsa:164832.
    UCSCiuc002tal.4. human. [Q1L5Z9-1]

    Polymorphism databases

    DMDMi313104224.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ020495 mRNA. Translation: AAY84832.1 .
    AK127206 mRNA. Translation: BAC86883.1 .
    AC104782 Genomic DNA. No translation available.
    AC012493 Genomic DNA. No translation available.
    BC101664 mRNA. Translation: AAI01665.1 .
    BC101662 mRNA. Translation: AAI01663.1 .
    CCDSi CCDS2046.2. [Q1L5Z9-1 ]
    RefSeqi NP_940863.3. NM_198461.3. [Q1L5Z9-1 ]
    UniGenei Hs.21380.

    3D structure databases

    ProteinModelPortali Q1L5Z9.
    SMRi Q1L5Z9. Positions 59-102, 192-290, 447-509.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127903. 2 interactions.
    IntActi Q1L5Z9. 1 interaction.
    STRINGi 9606.ENSP00000377086.

    PTM databases

    PhosphoSitei Q1L5Z9.

    Polymorphism databases

    DMDMi 313104224.

    Proteomic databases

    MaxQBi Q1L5Z9.
    PaxDbi Q1L5Z9.
    PRIDEi Q1L5Z9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393437 ; ENSP00000377086 ; ENSG00000170500 . [Q1L5Z9-1 ]
    ENST00000409647 ; ENSP00000386823 ; ENSG00000170500 . [Q1L5Z9-2 ]
    GeneIDi 164832.
    KEGGi hsa:164832.
    UCSCi uc002tal.4. human. [Q1L5Z9-1 ]

    Organism-specific databases

    CTDi 164832.
    GeneCardsi GC02M100889.
    H-InvDB HIX0024130.
    HGNCi HGNC:24788. LONRF2.
    neXtProti NX_Q1L5Z9.
    PharmGKBi PA142671540.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2802.
    HOGENOMi HOG000060199.
    HOVERGENi HBG081924.
    InParanoidi Q1L5Z9.
    OMAi KVMCEVL.
    OrthoDBi EOG7S7SD6.
    PhylomeDBi Q1L5Z9.
    TreeFami TF327043.

    Miscellaneous databases

    ChiTaRSi LONRF2. human.
    GenomeRNAii 164832.
    NextBioi 88502.
    PROi Q1L5Z9.

    Gene expression databases

    Bgeei Q1L5Z9.
    CleanExi HS_LONRF2.
    Genevestigatori Q1L5Z9.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    3.30.40.10. 2 hits.
    InterProi IPR003111. Pept_S16_N.
    IPR015947. PUA-like_domain.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF02190. LON. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 2 hits.
    SM00028. TPR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF88697. SSF88697. 1 hit.
    PROSITEi PS50293. TPR_REGION. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential screening of novel gene in apoptotic neuronal cells and its functional study during embryonic development."
      Choi D.K.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-426.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-426.
      Tissue: Hippocampus.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-426.
      Tissue: Brain.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-562.

    Entry informationi

    Entry nameiLONF2_HUMAN
    AccessioniPrimary (citable) accession number: Q1L5Z9
    Secondary accession number(s): B9A006, Q6ZSR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 75 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3