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Protein

LON peptidase N-terminal domain and RING finger protein 2

Gene

LONRF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri449 – 487RING-typePROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LON peptidase N-terminal domain and RING finger protein 2
Alternative name(s):
Neuroblastoma apoptosis-related protease
RING finger protein 192
Gene namesi
Name:LONRF2
Synonyms:RNF192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000170500.12
HGNCiHGNC:24788 LONRF2
neXtProtiNX_Q1L5Z9

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170500
PharmGKBiPA142671540

Polymorphism and mutation databases

BioMutaiLONRF2
DMDMi313104224

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002776701 – 754LON peptidase N-terminal domain and RING finger protein 2Add BLAST754

Proteomic databases

MaxQBiQ1L5Z9
PaxDbiQ1L5Z9
PeptideAtlasiQ1L5Z9
PRIDEiQ1L5Z9
ProteomicsDBi61220
61221 [Q1L5Z9-2]

PTM databases

iPTMnetiQ1L5Z9
PhosphoSitePlusiQ1L5Z9

Expressioni

Gene expression databases

BgeeiENSG00000170500
CleanExiHS_LONRF2
GenevisibleiQ1L5Z9 HS

Organism-specific databases

HPAiHPA057366

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127903, 13 interactors
IntActiQ1L5Z9, 1 interactor
STRINGi9606.ENSP00000377086

Structurei

3D structure databases

ProteinModelPortaliQ1L5Z9
SMRiQ1L5Z9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 58TPR 1Add BLAST36
Repeati59 – 91TPR 2Add BLAST33
Repeati197 – 230TPR 3Add BLAST34
Repeati231 – 264TPR 4Add BLAST34
Repeati266 – 298TPR 5Add BLAST33
Repeati447 – 483TPR 6Add BLAST37
Domaini535 – 735Lon N-terminalPROSITE-ProRule annotationAdd BLAST201

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 12Poly-Pro10

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri449 – 487RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0508 Eukaryota
KOG1124 Eukaryota
KOG4159 Eukaryota
COG2802 LUCA
GeneTreeiENSGT00440000033329
HOGENOMiHOG000060199
HOVERGENiHBG081924
InParanoidiQ1L5Z9
OMAiLTVCKRC
OrthoDBiEOG091G050D
PhylomeDBiQ1L5Z9
TreeFamiTF327043

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR003111 Lon_substr-bd
IPR015947 PUA-like_sf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR027370 Znf-RING_LisH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF02190 LON_substr_bdg, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00464 LON, 1 hit
SM00184 RING, 2 hits
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS51787 LON_N, 1 hit
PS50293 TPR_REGION, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1L5Z9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPEPVPPPP PPQCPGCDRA EPIAQRLEEG DEAFRAGDYE MAAELFRSML
60 70 80 90 100
AGLAQPDRGL CLRLGDALAR AGRLPEALGA FRGAARLGAL RPEELEELAG
110 120 130 140 150
GLVRAVGLRD RPLSAENPGG EPEAPGEGGP APEPRAPRDL LGCPRCRRLL
160 170 180 190 200
HKPVTLPCGL TVCKRCVEPG PARPQVRRVN VVLSGLLEKC FPAECRLRRL
210 220 230 240 250
AGQARSLQRQ QQPEAALLRC DQALELAPDD NSLLLLRAEL YLTMKNYEQA
260 270 280 290 300
LQDASAACQN EPLLIKGHQV KAQALSGLGR SKEVLKEFLY CLALNPECNS
310 320 330 340 350
VKKEAQKVMC EVLFSATANV HENLTSSIQS RLKAQGHSHM NAQALLEEGD
360 370 380 390 400
AGSSENSSEK SDMLGNTNSS VLYFILGLHF EEDKKALESI LPTAPSAGLK
410 420 430 440 450
RQFPDDVEDA PDLNAPGKIP KKDLSLQRSP NSETEESQGL SLDVTDFECA
460 470 480 490 500
LCMRLLFEPV TTPCGHTFCL KCLERCLDHA PHCPLCKDKL SELLASRNFN
510 520 530 540 550
ITVLAEELIF RYLPDELSDR KRIYDEEMSE LSNLTRDVPI FVCAMAFPTV
560 570 580 590 600
PCPLHVFEPR YRLMIRRCME TGTKRFGMCL SAEHAGLSEY GCMLEIKDVR
610 620 630 640 650
TFPDGSSVVD AIGISRFRVL SHRHRDGYNT ADIEYLEDEK VEGPEYEELA
660 670 680 690 700
ALHDSVHQQS VSWFASLQDR MKEQILSHFG VMPDREPEPQ SNPSGPAWSW
710 720 730 740 750
WILAVLPLER KAQLAILGMT SLKERLLAIR RILVIITRKM NSRQELANAR

ERNN
Length:754
Mass (Da):83,654
Last modified:November 30, 2010 - v3
Checksum:i688EE74DCF7893D3
GO
Isoform 2 (identifier: Q1L5Z9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.

Show »
Length:511
Mass (Da):57,487
Checksum:iAE7D01250CE317F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti648E → Q in AAY84832 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030590183L → P. Corresponds to variant dbSNP:rs4851287Ensembl.1
Natural variantiVAR_054639426L → P3 PublicationsCorresponds to variant dbSNP:rs4851287Ensembl.1
Natural variantiVAR_035953562R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs773205136Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0230791 – 243Missing in isoform 2. 2 PublicationsAdd BLAST243

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ020495 mRNA Translation: AAY84832.1
AK127206 mRNA Translation: BAC86883.1
AC104782 Genomic DNA No translation available.
AC012493 Genomic DNA No translation available.
BC101664 mRNA Translation: AAI01665.1
BC101662 mRNA Translation: AAI01663.1
CCDSiCCDS2046.2 [Q1L5Z9-1]
RefSeqiNP_940863.3, NM_198461.3 [Q1L5Z9-1]
UniGeneiHs.21380

Genome annotation databases

EnsembliENST00000393437; ENSP00000377086; ENSG00000170500 [Q1L5Z9-1]
ENST00000409647; ENSP00000386823; ENSG00000170500 [Q1L5Z9-2]
GeneIDi164832
KEGGihsa:164832
UCSCiuc002tal.4 human [Q1L5Z9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLONF2_HUMAN
AccessioniPrimary (citable) accession number: Q1L5Z9
Secondary accession number(s): B9A006, Q6ZSR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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