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Protein

LON peptidase N-terminal domain and RING finger protein 2

Gene

LONRF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri449 – 48739RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP-dependent peptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LON peptidase N-terminal domain and RING finger protein 2
Alternative name(s):
Neuroblastoma apoptosis-related protease
RING finger protein 192
Gene namesi
Name:LONRF2
Synonyms:RNF192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24788. LONRF2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671540.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754LON peptidase N-terminal domain and RING finger protein 2PRO_0000277670Add
BLAST

Proteomic databases

MaxQBiQ1L5Z9.
PaxDbiQ1L5Z9.
PRIDEiQ1L5Z9.

PTM databases

PhosphoSiteiQ1L5Z9.

Expressioni

Gene expression databases

BgeeiQ1L5Z9.
CleanExiHS_LONRF2.
GenevestigatoriQ1L5Z9.

Interactioni

Protein-protein interaction databases

BioGridi127903. 3 interactions.
IntActiQ1L5Z9. 1 interaction.
STRINGi9606.ENSP00000377086.

Structurei

3D structure databases

SMRiQ1L5Z9. Positions 26-105, 444-524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 5836TPR 1Add
BLAST
Repeati59 – 9133TPR 2Add
BLAST
Repeati197 – 23034TPR 3Add
BLAST
Repeati231 – 26434TPR 4Add
BLAST
Repeati266 – 29833TPR 5Add
BLAST
Repeati447 – 48337TPR 6Add
BLAST
Domaini530 – 738209LonAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 1210Poly-Pro

Sequence similaritiesi

Contains 1 Lon domain.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 6 TPR repeats.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri449 – 48739RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG2802.
GeneTreeiENSGT00440000033329.
HOGENOMiHOG000060199.
HOVERGENiHBG081924.
InParanoidiQ1L5Z9.
OMAiKVMCEVL.
OrthoDBiEOG7S7SD6.
PhylomeDBiQ1L5Z9.
TreeFamiTF327043.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
3.30.40.10. 2 hits.
InterProiIPR003111. Pept_S16_N.
IPR015947. PUA-like_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF02190. LON. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 2 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1L5Z9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPEPVPPPP PPQCPGCDRA EPIAQRLEEG DEAFRAGDYE MAAELFRSML
60 70 80 90 100
AGLAQPDRGL CLRLGDALAR AGRLPEALGA FRGAARLGAL RPEELEELAG
110 120 130 140 150
GLVRAVGLRD RPLSAENPGG EPEAPGEGGP APEPRAPRDL LGCPRCRRLL
160 170 180 190 200
HKPVTLPCGL TVCKRCVEPG PARPQVRRVN VVLSGLLEKC FPAECRLRRL
210 220 230 240 250
AGQARSLQRQ QQPEAALLRC DQALELAPDD NSLLLLRAEL YLTMKNYEQA
260 270 280 290 300
LQDASAACQN EPLLIKGHQV KAQALSGLGR SKEVLKEFLY CLALNPECNS
310 320 330 340 350
VKKEAQKVMC EVLFSATANV HENLTSSIQS RLKAQGHSHM NAQALLEEGD
360 370 380 390 400
AGSSENSSEK SDMLGNTNSS VLYFILGLHF EEDKKALESI LPTAPSAGLK
410 420 430 440 450
RQFPDDVEDA PDLNAPGKIP KKDLSLQRSP NSETEESQGL SLDVTDFECA
460 470 480 490 500
LCMRLLFEPV TTPCGHTFCL KCLERCLDHA PHCPLCKDKL SELLASRNFN
510 520 530 540 550
ITVLAEELIF RYLPDELSDR KRIYDEEMSE LSNLTRDVPI FVCAMAFPTV
560 570 580 590 600
PCPLHVFEPR YRLMIRRCME TGTKRFGMCL SAEHAGLSEY GCMLEIKDVR
610 620 630 640 650
TFPDGSSVVD AIGISRFRVL SHRHRDGYNT ADIEYLEDEK VEGPEYEELA
660 670 680 690 700
ALHDSVHQQS VSWFASLQDR MKEQILSHFG VMPDREPEPQ SNPSGPAWSW
710 720 730 740 750
WILAVLPLER KAQLAILGMT SLKERLLAIR RILVIITRKM NSRQELANAR

ERNN
Length:754
Mass (Da):83,654
Last modified:November 30, 2010 - v3
Checksum:i688EE74DCF7893D3
GO
Isoform 2 (identifier: Q1L5Z9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.

Show »
Length:511
Mass (Da):57,487
Checksum:iAE7D01250CE317F9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti648 – 6481E → Q in AAY84832 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti183 – 1831L → P.
Corresponds to variant rs4851287 [ dbSNP | Ensembl ].
VAR_030590
Natural varianti426 – 4261L → P.3 Publications
Corresponds to variant rs4851287 [ dbSNP | Ensembl ].
VAR_054639
Natural varianti562 – 5621R → W in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035953

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 243243Missing in isoform 2. 2 PublicationsVSP_023079Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ020495 mRNA. Translation: AAY84832.1.
AK127206 mRNA. Translation: BAC86883.1.
AC104782 Genomic DNA. No translation available.
AC012493 Genomic DNA. No translation available.
BC101664 mRNA. Translation: AAI01665.1.
BC101662 mRNA. Translation: AAI01663.1.
CCDSiCCDS2046.2. [Q1L5Z9-1]
RefSeqiNP_940863.3. NM_198461.3. [Q1L5Z9-1]
UniGeneiHs.21380.

Genome annotation databases

EnsembliENST00000393437; ENSP00000377086; ENSG00000170500. [Q1L5Z9-1]
ENST00000409647; ENSP00000386823; ENSG00000170500. [Q1L5Z9-2]
GeneIDi164832.
KEGGihsa:164832.
UCSCiuc002tal.4. human. [Q1L5Z9-1]

Polymorphism databases

DMDMi313104224.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ020495 mRNA. Translation: AAY84832.1.
AK127206 mRNA. Translation: BAC86883.1.
AC104782 Genomic DNA. No translation available.
AC012493 Genomic DNA. No translation available.
BC101664 mRNA. Translation: AAI01665.1.
BC101662 mRNA. Translation: AAI01663.1.
CCDSiCCDS2046.2. [Q1L5Z9-1]
RefSeqiNP_940863.3. NM_198461.3. [Q1L5Z9-1]
UniGeneiHs.21380.

3D structure databases

SMRiQ1L5Z9. Positions 26-105, 444-524.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127903. 3 interactions.
IntActiQ1L5Z9. 1 interaction.
STRINGi9606.ENSP00000377086.

PTM databases

PhosphoSiteiQ1L5Z9.

Polymorphism databases

DMDMi313104224.

Proteomic databases

MaxQBiQ1L5Z9.
PaxDbiQ1L5Z9.
PRIDEiQ1L5Z9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393437; ENSP00000377086; ENSG00000170500. [Q1L5Z9-1]
ENST00000409647; ENSP00000386823; ENSG00000170500. [Q1L5Z9-2]
GeneIDi164832.
KEGGihsa:164832.
UCSCiuc002tal.4. human. [Q1L5Z9-1]

Organism-specific databases

CTDi164832.
GeneCardsiGC02M100889.
H-InvDBHIX0024130.
HGNCiHGNC:24788. LONRF2.
neXtProtiNX_Q1L5Z9.
PharmGKBiPA142671540.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2802.
GeneTreeiENSGT00440000033329.
HOGENOMiHOG000060199.
HOVERGENiHBG081924.
InParanoidiQ1L5Z9.
OMAiKVMCEVL.
OrthoDBiEOG7S7SD6.
PhylomeDBiQ1L5Z9.
TreeFamiTF327043.

Miscellaneous databases

ChiTaRSiLONRF2. human.
GenomeRNAii164832.
NextBioi88502.
PROiQ1L5Z9.

Gene expression databases

BgeeiQ1L5Z9.
CleanExiHS_LONRF2.
GenevestigatoriQ1L5Z9.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
3.30.40.10. 2 hits.
InterProiIPR003111. Pept_S16_N.
IPR015947. PUA-like_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF02190. LON. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 2 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential screening of novel gene in apoptotic neuronal cells and its functional study during embryonic development."
    Choi D.K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-426.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-426.
    Tissue: Hippocampus.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-426.
    Tissue: Brain.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-562.

Entry informationi

Entry nameiLONF2_HUMAN
AccessioniPrimary (citable) accession number: Q1L5Z9
Secondary accession number(s): B9A006, Q6ZSR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 30, 2010
Last modified: April 1, 2015
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.