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Q1L5Z8 (HOG1_TORDE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase HOG1

Short name=MAP kinase HOG1
EC=2.7.11.24
Gene names
Name:HOG1
OrganismTorulaspora delbrueckii (Yeast) (Candida colliculosa)
Taxonomic identifier4950 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTorulaspora

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity. Involved in resistance to osmotic stress and tolerance to methylglyoxal and citric acid. Ref.1

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-174 and Tyr-176, which activates the enzyme By similarity. Phosphorylated during osmotic stress. Ref.1

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Mitogen-activated protein kinase HOG1
PRO_0000289702

Regions

Domain23 – 302280Protein kinase
Nucleotide binding29 – 379ATP By similarity
Motif174 – 1763TXY
Compositional bias364 – 38320Poly-Ala

Sites

Active site1441Proton acceptor By similarity
Binding site521ATP By similarity

Amino acid modifications

Modified residue1741Phosphothreonine By similarity
Modified residue1761Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1L5Z8 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: AC6BFC70A4D50D98

FASTA42748,021
        10         20         30         40         50         60 
MATHEEFIRT QVFGTVFEIT NRYTDLNPVG MGAFGLVCSA TDTLAQQPVA IKKIMKPFST 

        70         80         90        100        110        120 
AVLAKRTYRE LKLLKHLRHE NLICLQDIFL SPLEDIYFVT ELQGTDLHRL LQTRPLEKQF 

       130        140        150        160        170        180 
VQYFLYQILR GLKYVHSAGV IHRDLKPSNI LINENCDLKI CDFGLARIQD PQMTGYVSTR 

       190        200        210        220        230        240 
YYRAPEIMLT WQKYDVEVDI WSAGCIFAEM TEGKPLFPGK DHVHQFSIIT DLLGSPPEDV 

       250        260        270        280        290        300 
INTICSENTL KFVTSLPHRD PVPFRERFKT VEPEAVDLLE KMLVFDPKKR ITAADALVHP 

       310        320        330        340        350        360 
YLAPYHDPTD EPVADAKFDW NFNDADLPVD TWRVMMYSEI LDFHKIGGGD GQIDTSATFD 

       370        380        390        400        410        420 
DQVAAATAAA AHAAAVAQAQ AQAHSNSSNS NSSSNVNSKS KAARDSANDA ITNYGNQAVH 


YANEFQQ 

« Hide

References

[1]"Hog1 mitogen-activated protein kinase plays conserved and distinct roles in the osmotolerant yeast Torulaspora delbrueckii."
Hernandez-Lopez M.J., Randez-Gil F., Prieto J.A.
Eukaryot. Cell 5:1410-1419(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, PHOSPHORYLATION.
Strain: PYCC 5321 / CECT 11342.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ020519 Genomic DNA. Translation: AAY84830.1.

3D structure databases

ProteinModelPortalQ1L5Z8.
SMRQ1L5Z8. Positions 5-345.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01773. P38MAPKINASE.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHOG1_TORDE
AccessionPrimary (citable) accession number: Q1L5Z8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families