ID   FHIT_BOVIN              Reviewed;         149 AA.
AC   Q1KZG4; A6QLK1; Q1KZS9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Bis(5'-adenosyl)-triphosphatase;
DE            EC=3.6.1.29;
DE   AltName: Full=Diadenosine 5',5'''-P1,P3-triphosphate hydrolase;
DE   AltName: Full=Dinucleosidetriphosphatase;
DE   AltName: Full=AP3A hydrolase;
DE            Short=AP3Aase;
DE   AltName: Full=Fragile histidine triad protein;
GN   Name=FHIT;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16611727; DOI=10.1073/pnas.0601015103;
RA   Sugimoto M., Fujikawa A., Womack J.E., Sugimoto Y.;
RT   "Evidence that bovine forebrain embryonic zinc finger-like gene
RT   influences immune response associated with mastitis resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6454-6459(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF
RP   1-116, AND TISSUE SPECIFICITY.
RX   PubMed=16719907; DOI=10.1186/1471-2164-7-123;
RA   Uboldi C., Guidi E., Roperto S., Russo V., Roperto F., Di Meo G.P.,
RA   Iannuzzi L., Floriot S., Boussaha M., Eggen A., Ferretti L.;
RT   "Comparative genomic mapping of the bovine Fragile Histidine Triad
RT   (FHIT) tumour suppressor gene: characterization of a 2 Mb BAC contig
RT   covering the locus, complete annotation of the gene, analysis of cDNA
RT   and of physiological expression profiles.";
RL   BMC Genomics 7:123-123(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cleaves A-5'-PPP-5'A to yield AMP and ADP (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: P(1)-P(3)-bis(5'-adenosyl) triphosphate +
CC       H(2)O = ADP + AMP.
CC   -!- COFACTOR: Divalent cations. Magnesium, but manganese and to a
CC       lesser extent calcium or cobalt can be substituted; but not zinc,
CC       cadmium or nickel (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed in the brain, kidney, spleen, testis
CC       and lung.
CC   -!- SIMILARITY: Contains 1 HIT domain.
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DR   EMBL; DQ335870; ABC61315.1; -; mRNA.
DR   EMBL; DQ310184; ABC61471.1; -; mRNA.
DR   EMBL; DQ310183; ABC61470.1; -; mRNA.
DR   EMBL; DQ310181; ABC61468.1; -; mRNA.
DR   EMBL; DQ310182; ABC61469.1; -; mRNA.
DR   EMBL; DQ310179; ABC68307.1; -; Genomic_DNA.
DR   EMBL; DQ310176; ABC68307.1; JOINED; Genomic_DNA.
DR   EMBL; DQ310177; ABC68307.1; JOINED; Genomic_DNA.
DR   EMBL; DQ310178; ABC68307.1; JOINED; Genomic_DNA.
DR   EMBL; BC147993; AAI47994.1; -; mRNA.
DR   IPI; IPI00696363; -.
DR   RefSeq; NP_001035736.1; -.
DR   UniGene; Bt.26240; -.
DR   SMR; Q1KZG4; 2-131.
DR   Ensembl; ENSBTAG00000014418; Bos taurus.
DR   GeneID; 692183; -.
DR   KEGG; bta:692183; -.
DR   HOVERGEN; Q1KZG4; -.
DR   OMA; Q1KZG4; HILPRKA.
DR   BRENDA; 3.6.1.29; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0047710; F:bis(5'-adenosyl)-triphosphatase activity; IEA:EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR011151; His_triad_motif.
DR   InterPro; IPR019808; Histidine_triad_CS.
DR   InterPro; IPR001310; Histidine_triad_HIT.
DR   Gene3D; G3DSA:3.30.428.10; His_triad_motif; 1.
DR   PANTHER; PTHR23089; HIT; 1.
DR   Pfam; PF01230; HIT; 1.
DR   PROSITE; PS00892; HIT_1; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Magnesium; Manganese; Phosphoprotein.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    149       Bis(5'-adenosyl)-triphosphatase.
FT                                /FTId=PRO_0000288472.
FT   DOMAIN        2    109       HIT.
SQ   SEQUENCE   149 AA;  16951 MW;  C7E39594A5982F24 CRC64;
     MSFRFGQHLI KPSVVFLKTE LSFALVNRKP VVPGHVLVCP LRPVERFRDM SPEEVADLFQ
     AAQRVGTVVE KHFQGTSLTF SMQDGPEAGQ TVKHVHVHIL PRKAGDFHRN DSIYDALEKH
     DREDKDSPAL WRSEEEMAAE AAALRVYFQ
//