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Q1KTF2

- HOG1_MYCGM

UniProt

Q1KTF2 - HOG1_MYCGM

Protein

Mitogen-activated protein kinase Hog1

Gene

Hog1

Organism
Mycosphaerella graminicola (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by tyrosine and threonine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491ATPPROSITE-ProRule annotation
    Active sitei141 – 1411Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase Hog1 (EC:2.7.11.24)
    Short name:
    MAP kinase Hog1
    Short name:
    MgHog1
    Gene namesi
    Name:Hog1
    ORF Names:MYCGRDRAFT_76502
    OrganismiMycosphaerella graminicola (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
    Taxonomic identifieri336722 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeCapnodialesMycosphaerellaceaeZymoseptoria
    ProteomesiUP000008062: Chromosome 10

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Mitogen-activated protein kinase Hog1PRO_0000289696Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei171 – 1711PhosphothreonineBy similarity
    Modified residuei173 – 1731PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ1KTF2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1KTF2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 299280Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi171 – 1733TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK04441.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008352. MAPK_p38.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR01773. P38MAPKINASE.
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1KTF2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEFVRAQIF GTTFEITSRY TDLQPVGMGA FGLVCSAKDQ LTGQAVAVKK    50
    IMKPFSTPVL SKRTYRELKL LKHLKHENVI SLSDIFISPL EDIYFVTELL 100
    GTDLHRLLTS RPLEKQFIQY FLYQILRGLK YVHSAGVVHR DLKPSNILVN 150
    ENCDLKICDF GLARIQDPQM TGYVSTRYYR APEIMLTWQK YDVEVDIWSA 200
    GCIFAEMLEG KPLFPGKDHV NQFSIITDLL GTPPDDVIST ICSENTLRFV 250
    QSLPKRERQP LKNKFKNADP QAIELLERML VFDPRKRVKA GEALADPYLS 300
    PYHDPTDEPE AEEKFDWSFN DADLPVDTWK IMMYSEILDY HNVDSANNGE 350
    GQENGGA 357
    Length:357
    Mass (Da):40,768
    Last modified:June 27, 2006 - v2
    Checksum:i37B884F1A4B877D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ432031 Genomic DNA. Translation: ABD92790.2.
    CM001205 Genomic DNA. Translation: EGP84044.1.
    RefSeqiXP_003849068.1. XM_003849020.1.

    Genome annotation databases

    EnsemblFungiiMycgr3T76502; Mycgr3P76502; Mycgr3G76502.
    GeneIDi13398465.
    KEGGiztr:MYCGRDRAFT_76502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ432031 Genomic DNA. Translation: ABD92790.2 .
    CM001205 Genomic DNA. Translation: EGP84044.1 .
    RefSeqi XP_003849068.1. XM_003849020.1.

    3D structure databases

    ProteinModelPortali Q1KTF2.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q1KTF2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii Mycgr3T76502 ; Mycgr3P76502 ; Mycgr3G76502 .
    GeneIDi 13398465.
    KEGGi ztr:MYCGRDRAFT_76502.

    Phylogenomic databases

    KOi K04441.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008352. MAPK_p38.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR01773. P38MAPKINASE.
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MgHog1 regulates dimorphism and pathogenicity in the fungal wheat pathogen Mycosphaerella graminicola."
      Mehrabi R., Zwiers L.H., de Waard M.A., Kema G.H.
      Mol. Plant Microbe Interact. 19:1262-1269(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
      Strain: CBS 115943 / IPO323.
    2. "Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis."
      Goodwin S.B., Ben M'barek S., Dhillon B., Wittenberg A.H.J., Crane C.F., Hane J.K., Foster A.J., Van der Lee T.A.J., Grimwood J., Aerts A., Antoniw J., Bailey A., Bluhm B., Bowler J., Bristow J., van der Burgt A., Canto-Canche B., Churchill A.C.L.
      , Conde-Ferraez L., Cools H.J., Coutinho P.M., Csukai M., Dehal P., De Wit P., Donzelli B., van de Geest H.C., van Ham R.C.H.J., Hammond-Kosack K.E., Henrissat B., Kilian A., Kobayashi A.K., Koopmann E., Kourmpetis Y., Kuzniar A., Lindquist E., Lombard V., Maliepaard C., Martins N., Mehrabi R., Nap J.P.H., Ponomarenko A., Rudd J.J., Salamov A., Schmutz J., Schouten H.J., Shapiro H., Stergiopoulos I., Torriani S.F.F., Tu H., de Vries R.P., Waalwijk C., Ware S.B., Wiebenga A., Zwiers L.-H., Oliver R.P., Grigoriev I.V., Kema G.H.J.
      PLoS Genet. 7:E1002070-E1002070(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBS 115943 / IPO323.

    Entry informationi

    Entry nameiHOG1_MYCGM
    AccessioniPrimary (citable) accession number: Q1KTF2
    Secondary accession number(s): F9XLR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3