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Q1KTF2

- HOG1_MYCGM

UniProt

Q1KTF2 - HOG1_MYCGM

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Protein

Mitogen-activated protein kinase Hog1

Gene

Hog1

Organism
Mycosphaerella graminicola (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei141 – 1411Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase Hog1 (EC:2.7.11.24)
Short name:
MAP kinase Hog1
Short name:
MgHog1
Gene namesi
Name:Hog1
ORF Names:MYCGRDRAFT_76502
OrganismiMycosphaerella graminicola (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
Taxonomic identifieri336722 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeCapnodialesMycosphaerellaceaeZymoseptoria
ProteomesiUP000008062: Chromosome 10

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Mitogen-activated protein kinase Hog1PRO_0000289696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711PhosphothreonineBy similarity
Modified residuei173 – 1731PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ1KTF2.

Structurei

3D structure databases

ProteinModelPortaliQ1KTF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 299280Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi171 – 1733TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ1KTF2.
KOiK04441.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1KTF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEFVRAQIF GTTFEITSRY TDLQPVGMGA FGLVCSAKDQ LTGQAVAVKK
60 70 80 90 100
IMKPFSTPVL SKRTYRELKL LKHLKHENVI SLSDIFISPL EDIYFVTELL
110 120 130 140 150
GTDLHRLLTS RPLEKQFIQY FLYQILRGLK YVHSAGVVHR DLKPSNILVN
160 170 180 190 200
ENCDLKICDF GLARIQDPQM TGYVSTRYYR APEIMLTWQK YDVEVDIWSA
210 220 230 240 250
GCIFAEMLEG KPLFPGKDHV NQFSIITDLL GTPPDDVIST ICSENTLRFV
260 270 280 290 300
QSLPKRERQP LKNKFKNADP QAIELLERML VFDPRKRVKA GEALADPYLS
310 320 330 340 350
PYHDPTDEPE AEEKFDWSFN DADLPVDTWK IMMYSEILDY HNVDSANNGE

GQENGGA
Length:357
Mass (Da):40,768
Last modified:June 27, 2006 - v2
Checksum:i37B884F1A4B877D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ432031 Genomic DNA. Translation: ABD92790.2.
CM001205 Genomic DNA. Translation: EGP84044.1.
RefSeqiXP_003849068.1. XM_003849020.1.

Genome annotation databases

EnsemblFungiiMycgr3T76502; Mycgr3P76502; Mycgr3G76502.
GeneIDi13398465.
KEGGiztr:MYCGRDRAFT_76502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ432031 Genomic DNA. Translation: ABD92790.2 .
CM001205 Genomic DNA. Translation: EGP84044.1 .
RefSeqi XP_003849068.1. XM_003849020.1.

3D structure databases

ProteinModelPortali Q1KTF2.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q1KTF2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii Mycgr3T76502 ; Mycgr3P76502 ; Mycgr3G76502 .
GeneIDi 13398465.
KEGGi ztr:MYCGRDRAFT_76502.

Phylogenomic databases

InParanoidi Q1KTF2.
KOi K04441.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01773. P38MAPKINASE.
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MgHog1 regulates dimorphism and pathogenicity in the fungal wheat pathogen Mycosphaerella graminicola."
    Mehrabi R., Zwiers L.H., de Waard M.A., Kema G.H.
    Mol. Plant Microbe Interact. 19:1262-1269(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: CBS 115943 / IPO323.
  2. "Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis."
    Goodwin S.B., Ben M'barek S., Dhillon B., Wittenberg A.H.J., Crane C.F., Hane J.K., Foster A.J., Van der Lee T.A.J., Grimwood J., Aerts A., Antoniw J., Bailey A., Bluhm B., Bowler J., Bristow J., van der Burgt A., Canto-Canche B., Churchill A.C.L.
    , Conde-Ferraez L., Cools H.J., Coutinho P.M., Csukai M., Dehal P., De Wit P., Donzelli B., van de Geest H.C., van Ham R.C.H.J., Hammond-Kosack K.E., Henrissat B., Kilian A., Kobayashi A.K., Koopmann E., Kourmpetis Y., Kuzniar A., Lindquist E., Lombard V., Maliepaard C., Martins N., Mehrabi R., Nap J.P.H., Ponomarenko A., Rudd J.J., Salamov A., Schmutz J., Schouten H.J., Shapiro H., Stergiopoulos I., Torriani S.F.F., Tu H., de Vries R.P., Waalwijk C., Ware S.B., Wiebenga A., Zwiers L.-H., Oliver R.P., Grigoriev I.V., Kema G.H.J.
    PLoS Genet. 7:E1002070-E1002070(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 115943 / IPO323.

Entry informationi

Entry nameiHOG1_MYCGM
AccessioniPrimary (citable) accession number: Q1KTF2
Secondary accession number(s): F9XLR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 27, 2006
Last modified: November 26, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3