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Q1KQ07

- Q1KQ07_RAT

UniProt

Q1KQ07 - Q1KQ07_RAT

Protein

Signal transducer and activator of transcription

Gene

Stat6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    3. sequence-specific DNA binding Source: RGD
    4. sequence-specific DNA binding transcription factor activity Source: RGD
    5. signal transducer activity Source: InterPro

    GO - Biological processi

    1. cellular response to hydrogen peroxide Source: RGD
    2. cellular response to reactive nitrogen species Source: RGD
    3. cytokine-mediated signaling pathway Source: RGD
    4. interleukin-4-mediated signaling pathway Source: Ensembl
    5. mammary gland epithelial cell proliferation Source: Ensembl
    6. mammary gland morphogenesis Source: Ensembl
    7. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    8. negative regulation of type 2 immune response Source: Ensembl
    9. positive regulation of isotype switching to IgE isotypes Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter Source: RGD
    11. regulation of cell proliferation Source: Ensembl
    12. response to cytokine Source: RGD
    13. T-helper 1 cell lineage commitment Source: Ensembl
    14. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ActivatorUniRule annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_198377. STAT6-mediated induction of chemokines.
    REACT_206819. Downstream signal transduction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and activator of transcriptionUniRule annotation
    Gene namesi
    Name:Stat6Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi1309063. Stat6.

    Subcellular locationi

    Cytoplasm UniRule annotation
    Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane raft Source: RGD
    3. nuclear chromatin Source: Ensembl
    4. nucleus Source: RGD

    Keywords - Cellular componenti

    CytoplasmUniRule annotation, NucleusUniRule annotation

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ1KQ07.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.UniRule annotation
    Contains 1 SH2 domain.UniRule annotation

    Keywords - Domaini

    SH2 domainUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115175.
    HOGENOMiHOG000230988.
    HOVERGENiHBG107486.
    InParanoidiQ1KQ07.
    KOiK11225.
    OMAiKFQAGVR.
    OrthoDBiEOG73JKTT.
    TreeFamiTF318648.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR028187. STAT6_C.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF14596. STAT6_C. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1KQ07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLWSLVSKM SPEKLQRLYV DFPQHLRHLL AEWLENQPWE FLVGSDAFCY    50
    NMASALLSAT VQRLQASAGE QGKGSSLLQH ISTLESIYQR DPLKLVATIR 100
    QILQGEKKAV IEEFHHLPGP FHRKQEELKF TTALGRLQHR VRETRILRES 150
    LQQGTKTAQV SLKNLIDPPA NGTGPSEDLA TMLQGTVGDL EATQALVLKR 200
    IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ EIGAASGELE 250
    PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ 300
    FLGTSAKPPL VRADMVTEKQ ARELSLPQGS GAGVESTGEI MNNTVPLENS 350
    VPGNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFST SFMLGPNKHL 400
    IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK 450
    MCETLNLKFM AEVGTSRGLL PEHFLFLAQK IFNDNSLSIE AFQHRCVSWS 500
    QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL 550
    LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR 600
    SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV 650
    ERDQPLPTPE PQMPAMVAPY DLGMAPDASM QLSSDMVYPP QSHSIHSFQS 700
    IPLEESMSVL PPFQEPHLQM PPTMSQISMP FDQPHPQGLL QCQSQEHAVS 750
    SPEPLLCSDV TMAEDSCLTQ PVQGFPQGTW VSEGMYPPLM PPTEQDLTKL 800
    LLEGQGEGGG SIGTQPLLQP SSYGQSGISM SHLDLRTNPS W 841
    Length:841
    Mass (Da):93,870
    Last modified:May 30, 2006 - v1
    Checksum:i03E072CA817172F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06050244 Genomic DNA. No translation available.
    AABR06050245 Genomic DNA. No translation available.
    DQ462201 mRNA. Translation: ABE73454.1.
    RefSeqiNP_001037715.1. NM_001044250.1.
    UniGeneiRn.6880.

    Genome annotation databases

    EnsembliENSRNOT00000039306; ENSRNOP00000034983; ENSRNOG00000025023.
    GeneIDi362896.
    KEGGirno:362896.
    UCSCiRGD:1309063. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06050244 Genomic DNA. No translation available.
    AABR06050245 Genomic DNA. No translation available.
    DQ462201 mRNA. Translation: ABE73454.1 .
    RefSeqi NP_001037715.1. NM_001044250.1.
    UniGenei Rn.6880.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000039306 ; ENSRNOP00000034983 ; ENSRNOG00000025023 .
    GeneIDi 362896.
    KEGGi rno:362896.
    UCSCi RGD:1309063. rat.

    Organism-specific databases

    CTDi 6778.
    RGDi 1309063. Stat6.

    Phylogenomic databases

    GeneTreei ENSGT00740000115175.
    HOGENOMi HOG000230988.
    HOVERGENi HBG107486.
    InParanoidi Q1KQ07.
    KOi K11225.
    OMAi KFQAGVR.
    OrthoDBi EOG73JKTT.
    TreeFami TF318648.

    Enzyme and pathway databases

    Reactomei REACT_198377. STAT6-mediated induction of chemokines.
    REACT_206819. Downstream signal transduction.

    Miscellaneous databases

    NextBioi 681695.
    PROi Q1KQ07.

    Gene expression databases

    Genevestigatori Q1KQ07.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR028187. STAT6_C.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF14596. STAT6_C. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. "MEK-ERK signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells."
      Horiuchi M., Itoh A., Pleasure D., Itoh T.
      J. Biol. Chem. 281:20095-20106(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ1KQ07_RAT
    AccessioniPrimary (citable) accession number: Q1KQ07
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 30, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3