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Protein

Signal transducer and activator of transcription

Gene

Stat6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-186763. Downstream signal transduction.
R-RNO-3249367. STAT6-mediated induction of chemokines.
R-RNO-6785807. Interleukin-4 and 13 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:Stat6Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1309063. Stat6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000025023.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034983.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini517 – 632SH2InterPro annotationAdd BLAST116

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
GeneTreeiENSGT00760000119236.
HOGENOMiHOG000230988.
HOVERGENiHBG107486.
KOiK11225.
OMAiENSIPGN.
TreeFamiTF318648.

Family and domain databases

CDDicd10377. SH2_STAT6. 1 hit.
Gene3Di1.10.532.10. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR028187. STAT6_C.
IPR035857. STAT6_SH2.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF14596. STAT6_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1KQ07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLWSLVSKM SPEKLQRLYV DFPQHLRHLL AEWLENQPWE FLVGSDAFCY
60 70 80 90 100
NMASALLSAT VQRLQASAGE QGKGSSLLQH ISTLESIYQR DPLKLVATIR
110 120 130 140 150
QILQGEKKAV IEEFHHLPGP FHRKQEELKF TTALGRLQHR VRETRILRES
160 170 180 190 200
LQQGTKTAQV SLKNLIDPPA NGTGPSEDLA TMLQGTVGDL EATQALVLKR
210 220 230 240 250
IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ EIGAASGELE
260 270 280 290 300
PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ
310 320 330 340 350
FLGTSAKPPL VRADMVTEKQ ARELSLPQGS GAGVESTGEI MNNTVPLENS
360 370 380 390 400
VPGNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFST SFMLGPNKHL
410 420 430 440 450
IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK
460 470 480 490 500
MCETLNLKFM AEVGTSRGLL PEHFLFLAQK IFNDNSLSIE AFQHRCVSWS
510 520 530 540 550
QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL
560 570 580 590 600
LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR
610 620 630 640 650
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV
660 670 680 690 700
ERDQPLPTPE PQMPAMVAPY DLGMAPDASM QLSSDMVYPP QSHSIHSFQS
710 720 730 740 750
IPLEESMSVL PPFQEPHLQM PPTMSQISMP FDQPHPQGLL QCQSQEHAVS
760 770 780 790 800
SPEPLLCSDV TMAEDSCLTQ PVQGFPQGTW VSEGMYPPLM PPTEQDLTKL
810 820 830 840
LLEGQGEGGG SIGTQPLLQP SSYGQSGISM SHLDLRTNPS W
Length:841
Mass (Da):93,870
Last modified:May 30, 2006 - v1
Checksum:i03E072CA817172F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07057431 Genomic DNA. No translation available.
DQ462201 mRNA. Translation: ABE73454.1.
RefSeqiNP_001037715.1. NM_001044250.1.
UniGeneiRn.6880.

Genome annotation databases

EnsembliENSRNOT00000039306; ENSRNOP00000034983; ENSRNOG00000025023.
ENSRNOT00000085350; ENSRNOP00000072301; ENSRNOG00000025023.
GeneIDi362896.
KEGGirno:362896.
UCSCiRGD:1309063. rat.

Similar proteinsi

Entry informationi

Entry nameiQ1KQ07_RAT
AccessioniPrimary (citable) accession number: Q1KQ07
Entry historyiIntegrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: September 27, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported