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Q1KQ07 (Q1KQ07_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Signal transducer and activator of transcription RuleBase RU046415
Gene names
Name:Stat6 RGD 1309063 EMBL ABE73454.1 Ensembl ENSRNOP00000034983
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length841 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasm By similarity RuleBase RU046415.

Nucleus By similarity RuleBase RU046415.

Sequence similarities

Belongs to the transcription factor STAT family. RuleBase RU046415

Contains 1 SH2 domain. RuleBase RU046415

Ontologies

Keywords
   Biological processTranscription
Transcription regulation RuleBase RU046415
   Cellular componentCytoplasm RuleBase RU046415
Nucleus RuleBase RU046415
   DomainSH2 domain RuleBase RU046415
   LigandDNA-binding RuleBase RU046415
   Molecular functionActivator RuleBase RU046415
   PTMPhosphoprotein RuleBase RU046415
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT-helper 1 cell lineage commitment

Inferred from electronic annotation. Source: Ensembl

cellular response to hydrogen peroxide

Inferred from direct assay PubMed 22504638. Source: RGD

cellular response to reactive nitrogen species

Inferred from direct assay PubMed 22504638. Source: RGD

cytokine-mediated signaling pathway

Inferred from mutant phenotype PubMed 18362439. Source: RGD

interleukin-4-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

mammary gland epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

mammary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of type 2 immune response

Inferred from electronic annotation. Source: Ensembl

positive regulation of isotype switching to IgE isotypes

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 15584925. Source: RGD

regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

response to cytokine

Inferred from mutant phenotype PubMed 18362439. Source: RGD

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane raft

Inferred from direct assay PubMed 22504638. Source: RGD

nuclear chromatin

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 16648019. Source: RGD

   Molecular_functionRNA polymerase II core promoter sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

calcium ion binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding

Inferred from direct assay PubMed 16648019. Source: RGD

sequence-specific DNA binding transcription factor activity

Inferred from mutant phenotype PubMed 15584925. Source: RGD

signal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q1KQ07 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 03E072CA817172F5

FASTA84193,870
        10         20         30         40         50         60 
MSLWSLVSKM SPEKLQRLYV DFPQHLRHLL AEWLENQPWE FLVGSDAFCY NMASALLSAT 

        70         80         90        100        110        120 
VQRLQASAGE QGKGSSLLQH ISTLESIYQR DPLKLVATIR QILQGEKKAV IEEFHHLPGP 

       130        140        150        160        170        180 
FHRKQEELKF TTALGRLQHR VRETRILRES LQQGTKTAQV SLKNLIDPPA NGTGPSEDLA 

       190        200        210        220        230        240 
TMLQGTVGDL EATQALVLKR IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ 

       250        260        270        280        290        300 
EIGAASGELE PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ 

       310        320        330        340        350        360 
FLGTSAKPPL VRADMVTEKQ ARELSLPQGS GAGVESTGEI MNNTVPLENS VPGNCCSALF 

       370        380        390        400        410        420 
KNLLLKKIKR CERKGTESVT EEKCAVLFST SFMLGPNKHL IQLQALSLPL VVIVHGNQDN 

       430        440        450        460        470        480 
NAKATILWDN AFSEMDRVPF VVAERVPWEK MCETLNLKFM AEVGTSRGLL PEHFLFLAQK 

       490        500        510        520        530        540 
IFNDNSLSIE AFQHRCVSWS QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG 

       550        560        570        580        590        600 
FISKQYVTSL LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR 

       610        620        630        640        650        660 
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV ERDQPLPTPE 

       670        680        690        700        710        720 
PQMPAMVAPY DLGMAPDASM QLSSDMVYPP QSHSIHSFQS IPLEESMSVL PPFQEPHLQM 

       730        740        750        760        770        780 
PPTMSQISMP FDQPHPQGLL QCQSQEHAVS SPEPLLCSDV TMAEDSCLTQ PVQGFPQGTW 

       790        800        810        820        830        840 
VSEGMYPPLM PPTEQDLTKL LLEGQGEGGG SIGTQPLLQP SSYGQSGISM SHLDLRTNPS 


W 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000034983.
[2]"MEK-ERK signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells."
Horiuchi M., Itoh A., Pleasure D., Itoh T.
J. Biol. Chem. 281:20095-20106(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Sprague-Dawley EMBL ABE73454.1.
[3]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000034983.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06050244 Genomic DNA. No translation available.
AABR06050245 Genomic DNA. No translation available.
DQ462201 mRNA. Translation: ABE73454.1.
RefSeqNP_001037715.1. NM_001044250.1.
UniGeneRn.6880.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000039306; ENSRNOP00000034983; ENSRNOG00000025023.
GeneID362896.
KEGGrno:362896.
UCSCRGD:1309063. rat.

Organism-specific databases

CTD6778.
RGD1309063. Stat6.

Phylogenomic databases

GeneTreeENSGT00740000115175.
HOGENOMHOG000230988.
HOVERGENHBG107486.
InParanoidQ1KQ07.
KOK11225.
OMAKFQAGVR.
OrthoDBEOG73JKTT.
TreeFamTF318648.

Gene expression databases

GenevestigatorQ1KQ07.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR028187. STAT6_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERPTHR11801. PTHR11801. 1 hit.
PfamPF00017. SH2. 1 hit.
PF14596. STAT6_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio681695.
PROQ1KQ07.

Entry information

Entry nameQ1KQ07_RAT
AccessionPrimary (citable) accession number: Q1KQ07
Entry history
Integrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)