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Protein

Signal transducer and activator of transcription

Gene

Stat6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding Source: RGD
  3. sequence-specific DNA binding transcription factor activity Source: RGD
  4. signal transducer activity Source: InterPro

GO - Biological processi

  1. cellular response to hydrogen peroxide Source: RGD
  2. cellular response to reactive nitrogen species Source: RGD
  3. cytokine-mediated signaling pathway Source: RGD
  4. interleukin-4-mediated signaling pathway Source: Ensembl
  5. mammary gland epithelial cell proliferation Source: Ensembl
  6. mammary gland morphogenesis Source: Ensembl
  7. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  8. negative regulation of type 2 immune response Source: Ensembl
  9. positive regulation of isotype switching to IgE isotypes Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: RGD
  11. regulation of cell proliferation Source: Ensembl
  12. response to cytokine Source: RGD
  13. T-helper 1 cell lineage commitment Source: Ensembl
  14. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_273670. STAT6-mediated induction of chemokines.
REACT_301200. Downstream signal transduction.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:Stat6Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1309063. Stat6.

Subcellular locationi

  1. Cytoplasm UniRule annotation
  1. Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. membrane raft Source: RGD
  3. nuclear chromatin Source: Ensembl
  4. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

GenevestigatoriQ1KQ07.

Family & Domainsi

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation
Contains 1 SH2 domain.UniRule annotation

Keywords - Domaini

SH2 domainUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119236.
HOGENOMiHOG000230988.
HOVERGENiHBG107486.
KOiK11225.
OMAiKFQAGVR.
OrthoDBiEOG73JKTT.
TreeFamiTF318648.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR028187. STAT6_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF14596. STAT6_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1KQ07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLWSLVSKM SPEKLQRLYV DFPQHLRHLL AEWLENQPWE FLVGSDAFCY
60 70 80 90 100
NMASALLSAT VQRLQASAGE QGKGSSLLQH ISTLESIYQR DPLKLVATIR
110 120 130 140 150
QILQGEKKAV IEEFHHLPGP FHRKQEELKF TTALGRLQHR VRETRILRES
160 170 180 190 200
LQQGTKTAQV SLKNLIDPPA NGTGPSEDLA TMLQGTVGDL EATQALVLKR
210 220 230 240 250
IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ EIGAASGELE
260 270 280 290 300
PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ
310 320 330 340 350
FLGTSAKPPL VRADMVTEKQ ARELSLPQGS GAGVESTGEI MNNTVPLENS
360 370 380 390 400
VPGNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFST SFMLGPNKHL
410 420 430 440 450
IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK
460 470 480 490 500
MCETLNLKFM AEVGTSRGLL PEHFLFLAQK IFNDNSLSIE AFQHRCVSWS
510 520 530 540 550
QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL
560 570 580 590 600
LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR
610 620 630 640 650
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV
660 670 680 690 700
ERDQPLPTPE PQMPAMVAPY DLGMAPDASM QLSSDMVYPP QSHSIHSFQS
710 720 730 740 750
IPLEESMSVL PPFQEPHLQM PPTMSQISMP FDQPHPQGLL QCQSQEHAVS
760 770 780 790 800
SPEPLLCSDV TMAEDSCLTQ PVQGFPQGTW VSEGMYPPLM PPTEQDLTKL
810 820 830 840
LLEGQGEGGG SIGTQPLLQP SSYGQSGISM SHLDLRTNPS W
Length:841
Mass (Da):93,870
Last modified:May 30, 2006 - v1
Checksum:i03E072CA817172F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06050244 Genomic DNA. No translation available.
AABR06050245 Genomic DNA. No translation available.
DQ462201 mRNA. Translation: ABE73454.1.
RefSeqiNP_001037715.1. NM_001044250.1.
UniGeneiRn.6880.

Genome annotation databases

EnsembliENSRNOT00000039306; ENSRNOP00000034983; ENSRNOG00000025023.
GeneIDi362896.
KEGGirno:362896.
UCSCiRGD:1309063. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06050244 Genomic DNA. No translation available.
AABR06050245 Genomic DNA. No translation available.
DQ462201 mRNA. Translation: ABE73454.1.
RefSeqiNP_001037715.1. NM_001044250.1.
UniGeneiRn.6880.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039306; ENSRNOP00000034983; ENSRNOG00000025023.
GeneIDi362896.
KEGGirno:362896.
UCSCiRGD:1309063. rat.

Organism-specific databases

CTDi6778.
RGDi1309063. Stat6.

Phylogenomic databases

GeneTreeiENSGT00760000119236.
HOGENOMiHOG000230988.
HOVERGENiHBG107486.
KOiK11225.
OMAiKFQAGVR.
OrthoDBiEOG73JKTT.
TreeFamiTF318648.

Enzyme and pathway databases

ReactomeiREACT_273670. STAT6-mediated induction of chemokines.
REACT_301200. Downstream signal transduction.

Miscellaneous databases

NextBioi681695.
PROiQ1KQ07.

Gene expression databases

GenevestigatoriQ1KQ07.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR028187. STAT6_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF14596. STAT6_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. "MEK-ERK signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells."
    Horiuchi M., Itoh A., Pleasure D., Itoh T.
    J. Biol. Chem. 281:20095-20106(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ1KQ07_RAT
AccessioniPrimary (citable) accession number: Q1KQ07
Entry historyi
Integrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: April 29, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.