Q1KQ07 (Q1KQ07_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Stat6 Ensembl ENSRNOP00000034983

Submitted name:
STAT6 EMBL ABE73454.1

Gene names

Name:

Stat6 RGD 1309063 EMBL ABE73454.1 Ensembl ENSRNOP00000034983

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	841 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T-helper 1 cell lineage commitment Inferred from electronic annotation. Source: Compara cytokine-mediated signaling pathway Inferred from mutant phenotype PubMed 18362439. Source: RGD mammary gland epithelial cell proliferation Inferred from electronic annotation. Source: Compara mammary gland morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara negative regulation of type 2 immune response Inferred from electronic annotation. Source: Compara positive regulation of isotype switching to IgE isotypes Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 15584925. Source: RGD regulation of cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nuclear chromatin Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay PubMed 16648019. Source: RGD
Molecular_function	RNA polymerase II core promoter sequence-specific DNA binding Inferred from electronic annotation. Source: Compara calcium ion binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from direct assay PubMed 16648019. Source: RGD sequence-specific DNA binding transcription factor activity Inferred from mutant phenotype PubMed 15584925. Source: RGD signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q1KQ07 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 03E072CA817172F5	FASTA	841	93,870
	10 20 30 40 50 60 MSLWSLVSKM SPEKLQRLYV DFPQHLRHLL AEWLENQPWE FLVGSDAFCY NMASALLSAT 70 80 90 100 110 120 VQRLQASAGE QGKGSSLLQH ISTLESIYQR DPLKLVATIR QILQGEKKAV IEEFHHLPGP 130 140 150 160 170 180 FHRKQEELKF TTALGRLQHR VRETRILRES LQQGTKTAQV SLKNLIDPPA NGTGPSEDLA 190 200 210 220 230 240 TMLQGTVGDL EATQALVLKR IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ 250 260 270 280 290 300 EIGAASGELE PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ 310 320 330 340 350 360 FLGTSAKPPL VRADMVTEKQ ARELSLPQGS GAGVESTGEI MNNTVPLENS VPGNCCSALF 370 380 390 400 410 420 KNLLLKKIKR CERKGTESVT EEKCAVLFST SFMLGPNKHL IQLQALSLPL VVIVHGNQDN 430 440 450 460 470 480 NAKATILWDN AFSEMDRVPF VVAERVPWEK MCETLNLKFM AEVGTSRGLL PEHFLFLAQK 490 500 510 520 530 540 IFNDNSLSIE AFQHRCVSWS QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG 550 560 570 580 590 600 FISKQYVTSL LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR 610 620 630 640 650 660 SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV ERDQPLPTPE 670 680 690 700 710 720 PQMPAMVAPY DLGMAPDASM QLSSDMVYPP QSHSIHSFQS IPLEESMSVL PPFQEPHLQM 730 740 750 760 770 780 PPTMSQISMP FDQPHPQGLL QCQSQEHAVS SPEPLLCSDV TMAEDSCLTQ PVQGFPQGTW 790 800 810 820 830 840 VSEGMYPPLM PPTEQDLTKL LLEGQGEGGG SIGTQPLLQP SSYGQSGISM SHLDLRTNPS W

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000034983.
[2]	"MEK-ERK signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells." Horiuchi M., Itoh A., Pleasure D., Itoh T. J. Biol. Chem. 281:20095-20106(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL ABE73454.1.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000034983.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06050244 Genomic DNA. No translation available. AABR06050245 Genomic DNA. No translation available. DQ462201 mRNA. Translation: ABE73454.1.
IPI	IPI00389459.
RefSeq	NP_001037715.1. NM_001044250.1.
UniGene	Rn.6880.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000039306; ENSRNOP00000034983; ENSRNOG00000025023.
GeneID	362896.
KEGG	rno:362896.
UCSC	RGD:1309063. rat.
Organism-specific databases
CTD	6778.
RGD	1309063. Stat6.
Phylogenomic databases
GeneTree	ENSGT00550000074337.
HOGENOM	HOG000230988.
HOVERGEN	HBG107486.
InParanoid	Q1KQ07.
KO	K11225.
OMA	KFQAGVR.
Gene expression databases
Genevestigator	Q1KQ07.
Family and domain databases
Gene3D	1.10.238.10. 1 hit. 1.10.532.10. 1 hit. 1.20.1050.20. 1 hit. 2.60.40.630. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR008967. p53-like_TF_DNA-bd. IPR000980. SH2. IPR013800. STAT_TF_alpha. IPR015988. STAT_TF_coiled-coil. IPR001217. STAT_TF_core. IPR013801. STAT_TF_DNA-bd. IPR012345. STAT_TF_DNA-bd_sub. IPR013799. STAT_TF_prot_interaction. [Graphical view]
PANTHER	PTHR11801. PTHR11801. 1 hit.
Pfam	PF00017. SH2. 1 hit. PF01017. STAT_alpha. 1 hit. PF02864. STAT_bind. 1 hit. PF02865. STAT_int. 1 hit. [Graphical view]
SMART	SM00252. SH2. 1 hit. SM00964. STAT_int. 1 hit. [Graphical view]
SUPFAM	SSF49417. P53_like_DNA_bnd. 1 hit. SSF47655. STAT. 1 hit. SSF48092. STAT. 1 hit.
PROSITE	PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	681695.

Entry information

Entry name

Q1KQ07_RAT

Accession

Primary (citable) accession number: Q1KQ07

Entry history

Integrated into UniProtKB/TrEMBL:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)