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Q1KMR4 (PDK4_RHIFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 31, 2011. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
EC=2.7.11.2
Alternative name(s):
Pyruvate dehydrogenase kinase isoform 4
Gene names
Name:PDK4
OrganismRhinolophus ferrumequinum (Greater horseshoe bat)
Taxonomic identifier59479 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Chiroptera › Microchiroptera › Rhinolophidae › Rhinolophinae › Rhinolophus

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism By similarity.

Catalytic activity

ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the PDK/BCKDK protein kinase family.

Contains 1 histidine kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 412[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialPRO_0000261316

Regions

Domain138 – 368231Histidine kinase
Nucleotide binding254 – 2618ATP By similarity
Nucleotide binding312 – 3132ATP By similarity
Nucleotide binding329 – 3346ATP By similarity

Sites

Binding site2931ATP By similarity

Amino acid modifications

Modified residue1271Phosphohistidine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1KMR4 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: D8A4EBA1F50F7316

FASTA41246,654
        10         20         30         40         50         60 
MKAARFVMRS ARSLSSAGLV PREVEHFSRY SPSPLSMKQL LDFGSENACE RTSSAFLRQE 

        70         80         90        100        110        120 
LPVRLANILK EIDILPDRLV NTSSVQLVKS WYIQSLMELV EFHERSPDDQ KVLSDFVDTL 

       130        140        150        160        170        180 
ITVRNRHHNV VPTMAQGIIE YKDSCTVDPV TNQNLQYFLD RFYMNRISTR MLMNQHILIF 

       190        200        210        220        230        240 
SDSQTGNPSH IGSIDPNCNV AAVVQDAFEC SRMLCDQYYL TSPELKLTQV NGKFPGEPIH 

       250        260        270        280        290        300 
IVYVPSHLHH MLFELFKNAM RATVEHQENE PSLTPVEVTV VLGKEDLTIK ISDRGGGVPL 

       310        320        330        340        350        360 
RITDRLFSYM YSTAPTPVMD NSRNAPLAGF GYGLPISRLY AKYFQGDLHL YSLSGYGTDA 

       370        380        390        400        410 
IIYLKALSSE SVEKLPVFNK SAFKHYQMSI EADDWCIPSK EPKNLAKEKV AV

« Hide

References

[1]"Sequence and expression of transcription factor genes, pyruvate dehydrogenase kinase isoenzyme 4 (PDK4), from the hibernating bat (Rhinolophus ferrumequinum)."
Chen J., Sun M., Wu D., Zhang S.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ468386 mRNA. Translation: ABF13212.1.

3D structure databases

ProteinModelPortalQ1KMR4.
SMRQ1KMR4. Positions 20-386.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000511.

Enzyme and pathway databases

BRENDA2.7.11.2. 9215.

Family and domain databases

InterProIPR003594. ATPase-like_ATP-bd.
IPR018955. BCDHK/PDK_N.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view]
Gene3DG3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
G3DSA:1.20.140.20. BCDHK/PDK_N. 1 hit.
PfamPF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view]
SMARTSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMSSF55874. ATP_bd_ATPase. 1 hit.
SSF69012. BCDHK/PDK_N. 1 hit.
PROSITEPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDK4_RHIFE
AccessionPrimary (citable) accession number: Q1KMR4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 30, 2006
Last modified: May 31, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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