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Q1KMD3 (HNRL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heterogeneous nuclear ribonucleoprotein U-like protein 2
Alternative name(s):
Scaffold-attachment factor A2
Short name=SAF-A2
Gene names
Name:HNRNPUL2
Synonyms:HNRPUL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length747 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Binds to MLF1 and retains it in the nucleus By similarity. UniProtKB Q00PI9

Subcellular location

Nucleus By similarity UniProtKB Q00PI9.

Sequence similarities

Contains 1 B30.2/SPRY domain.

Contains 1 SAP domain.

Ontologies

Keywords
   Cellular componentNucleus
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 747747Heterogeneous nuclear ribonucleoprotein U-like protein 2
PRO_0000278142

Regions

Domain3 – 3735SAP
Domain226 – 419194B30.2/SPRY
Compositional bias75 – 241167Glu-rich
Compositional bias668 – 74679Tyr-rich

Amino acid modifications

Modified residue1611Phosphoserine By similarity PubMed 16964243
Modified residue2281Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q1KMD3 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 7EAAC2F598330AAA

FASTA74785,105
        10         20         30         40         50         60 
MEVKRLKVTE LRSELQRRGL DSRGLKVDLA QRLQEALDAE MLEDEAGGGG AGPGGACKAE 

        70         80         90        100        110        120 
PRPVAASGGG PGGDEEEDEE EEEEDEEALL EDEDEEPPPA QALGQAAQPP PEPPEAAAME 

       130        140        150        160        170        180 
AAAEPDASEK PAEATAGSGG VNGGEEQGLG KREEDEPEER SGDETPGSEV PGDKAAEEQG 

       190        200        210        220        230        240 
DDQDSEKSKP AGSDGERRGV KRQRDEKDEH GRAYYEFREE AYHSRSKSPL PPEEEAKDEE 

       250        260        270        280        290        300 
EDQTLVNLDT YTSDLHFQVS KDRYGGQPLF SEKFPTLWSG ARSTYGVTKG KVCFEAKVTQ 

       310        320        330        340        350        360 
NLPMKEGCTE VSLLRVGWSV DFSRPQLGED EFSYGFDGRG LKAENGQFEE FGQTFGENDV 

       370        380        390        400        410        420 
IGCFANFETE EVELSFSKNG EDLGVAFWIS KDSLADRALL PHVLCKNCVV ELNFGQKEEP 

       430        440        450        460        470        480 
FFPPPEEFVF IHAVPVEERV RTAVPPKTIE ECEVILMVGL PGSGKTQWAL KYAKENPEKR 

       490        500        510        520        530        540 
YNVLGAETVL NQMRMKGLEE PEMDPKSRDL LVQQASQCLS KLVQIASRTK RNFILDQCNV 

       550        560        570        580        590        600 
YNSGQRRKLL LFKTFSRKVV VVVPNEEDWK KRLELRKEVE GDDVPESIML EMKANFSLPE 

       610        620        630        640        650        660 
KCDYMDEVTY GELEKEEAQP IVTKYKEEAR KLLPPSEKRT NRRNNRNKRN RQNRSRGQGY 

       670        680        690        700        710        720 
VGGQRRGYDN RAYGQQYWGQ PGNRGGYRNF YDRYRGDYDR FYGRDYEYNR YRDYYRQYNR 

       730        740 
DWQSYYYHHP QDRDRYYRNY YGYQGYR 

« Hide

References

« Hide 'large scale' references
[1]"Scaffold attachment factor A2 (SAF-A2), a mobile isoform of a nucleoskeletal human protein."
Herrmann F., Fackelmayer F.O.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-747.
Tissue: Melanoma.
[3]Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
Submitted (DEC-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 161-174; 213-218; 226-237; 264-282; 298-315; 379-391; 481-494; 497-506; 509-521; 558-570; 594-601; 721-733 AND 739-747, PHOSPHORYLATION AT SER-228, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Ovarian carcinoma.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ470474 mRNA. Translation: ABF00125.1.
AL834470 mRNA. Translation: CAD39129.2.
RefSeqNP_001073027.1. NM_001079559.2.
UniGeneHs.657058.

3D structure databases

ProteinModelPortalQ1KMD3.
SMRQ1KMD3. Positions 1-37, 452-579.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128685. 26 interactions.
IntActQ1KMD3. 4 interactions.
MINTMINT-4654781.
STRING9606.ENSP00000301785.

PTM databases

PhosphoSiteQ1KMD3.

Polymorphism databases

DMDM121940728.

Proteomic databases

PaxDbQ1KMD3.
PeptideAtlasQ1KMD3.
PRIDEQ1KMD3.

Protocols and materials databases

DNASU221092.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301785; ENSP00000301785; ENSG00000214753.
GeneID221092.
KEGGhsa:221092.
UCSCuc001nuw.3. human.

Organism-specific databases

CTD221092.
GeneCardsGC11M062482.
HGNCHGNC:25451. HNRNPUL2.
HPAHPA041632.
neXtProtNX_Q1KMD3.
PharmGKBPA162391554.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG297571.
HOGENOMHOG000253920.
HOVERGENHBG061101.
InParanoidQ1KMD3.
OMADYEYNRY.
OrthoDBEOG79CZ07.
PhylomeDBQ1KMD3.
TreeFamTF317301.

Gene expression databases

BgeeQ1KMD3.
CleanExHS_HNRNPUL2.
GenevestigatorQ1KMD3.

Family and domain databases

Gene3D1.10.720.30. 1 hit.
3.40.50.300. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR026745. hnRNP_U.
IPR027417. P-loop_NTPase.
IPR003034. SAP_dom.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PANTHERPTHR12381:SF11. PTHR12381:SF11. 1 hit.
PfamPF02037. SAP. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTSM00513. SAP. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50800. SAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHNRNPUL2. human.
GenomeRNAi221092.
NextBio91196.
PMAP-CutDBQ1KMD3.
PROQ1KMD3.

Entry information

Entry nameHNRL2_HUMAN
AccessionPrimary (citable) accession number: Q1KMD3
Secondary accession number(s): Q8N3B3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM