Q1KMD3 (HNRL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heterogeneous nuclear ribonucleoprotein U-like protein 2

Alternative name(s):
Scaffold-attachment factor A2
Short name=SAF-A2

Gene names

Name:	HNRNPUL2
Synonyms:	HNRPUL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	747 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Binds to MLF1 and retains it in the nucleus By similarity. UniProtKB Q00PI9
Subcellular location	Nucleus By similarity UniProtKB Q00PI9.
Sequence similarities	Contains 1 B30.2/SPRY domain. Contains 1 SAP domain.

Ontologies

Keywords
Cellular component	Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 747	747	Heterogeneous nuclear ribonucleoprotein U-like protein 2		PRO_0000278142
Regions
	Domain	3 – 37	35	SAP
	Domain	226 – 419	194	B30.2/SPRY
	Compositional bias	75 – 241	167	Glu-rich
	Compositional bias	668 – 746	79	Tyr-rich
Amino acid modifications
	Modified residue	161	1	Phosphoserine By similarity
	Modified residue	188	1	Phosphoserine By similarity
	Modified residue	228	1	Phosphoserine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q1KMD3 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 7EAAC2F598330AAA	FASTA	747	85,105
	10 20 30 40 50 60 MEVKRLKVTE LRSELQRRGL DSRGLKVDLA QRLQEALDAE MLEDEAGGGG AGPGGACKAE 70 80 90 100 110 120 PRPVAASGGG PGGDEEEDEE EEEEDEEALL EDEDEEPPPA QALGQAAQPP PEPPEAAAME 130 140 150 160 170 180 AAAEPDASEK PAEATAGSGG VNGGEEQGLG KREEDEPEER SGDETPGSEV PGDKAAEEQG 190 200 210 220 230 240 DDQDSEKSKP AGSDGERRGV KRQRDEKDEH GRAYYEFREE AYHSRSKSPL PPEEEAKDEE 250 260 270 280 290 300 EDQTLVNLDT YTSDLHFQVS KDRYGGQPLF SEKFPTLWSG ARSTYGVTKG KVCFEAKVTQ 310 320 330 340 350 360 NLPMKEGCTE VSLLRVGWSV DFSRPQLGED EFSYGFDGRG LKAENGQFEE FGQTFGENDV 370 380 390 400 410 420 IGCFANFETE EVELSFSKNG EDLGVAFWIS KDSLADRALL PHVLCKNCVV ELNFGQKEEP 430 440 450 460 470 480 FFPPPEEFVF IHAVPVEERV RTAVPPKTIE ECEVILMVGL PGSGKTQWAL KYAKENPEKR 490 500 510 520 530 540 YNVLGAETVL NQMRMKGLEE PEMDPKSRDL LVQQASQCLS KLVQIASRTK RNFILDQCNV 550 560 570 580 590 600 YNSGQRRKLL LFKTFSRKVV VVVPNEEDWK KRLELRKEVE GDDVPESIML EMKANFSLPE 610 620 630 640 650 660 KCDYMDEVTY GELEKEEAQP IVTKYKEEAR KLLPPSEKRT NRRNNRNKRN RQNRSRGQGY 670 680 690 700 710 720 VGGQRRGYDN RAYGQQYWGQ PGNRGGYRNF YDRYRGDYDR FYGRDYEYNR YRDYYRQYNR 730 740 DWQSYYYHHP QDRDRYYRNY YGYQGYR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Scaffold attachment factor A2 (SAF-A2), a mobile isoform of a nucleoskeletal human protein." Herrmann F., Fackelmayer F.O. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-747. Tissue: Melanoma.
[3]	Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 161-174; 213-218; 226-237; 264-282; 298-315; 379-391; 481-494; 497-506; 509-521; 558-570; 594-601; 721-733 AND 739-747, PHOSPHORYLATION AT SER-228, MASS SPECTROMETRY. Tissue: Ovarian carcinoma.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ470474 mRNA. Translation: ABF00125.1. AL834470 mRNA. Translation: CAD39129.2.
IPI	IPI00456887.
RefSeq	NP_001073027.1. NM_001079559.2.
UniGene	Hs.657058.
3D structure databases
ProteinModelPortal	Q1KMD3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q1KMD3. 2 interactions.
STRING	9606.ENSP00000301785.
PTM databases
PhosphoSite	Q1KMD3.
Polymorphism databases
DMDM	121940728.
Proteomic databases
PaxDb	Q1KMD3.
PeptideAtlas	Q1KMD3.
PRIDE	Q1KMD3.
Protocols and materials databases
DNASU	221092.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301785; ENSP00000301785; ENSG00000214753.
GeneID	221092.
KEGG	hsa:221092.
UCSC	uc001nuw.3. human.
Organism-specific databases
CTD	221092.
GeneCards	GC11M062482.
HGNC	HGNC:25451. HNRNPUL2.
HPA	HPA041632.
neXtProt	NX_Q1KMD3.
PharmGKB	PA162391554.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG297571.
HOGENOM	HOG000253920.
HOVERGEN	HBG061101.
InParanoid	Q1KMD3.
OMA	DYEYNRY.
OrthoDB	EOG4N30NM.
Gene expression databases
Bgee	Q1KMD3.
CleanEx	HS_HNRNPUL2.
Genevestigator	Q1KMD3.
Family and domain databases
Gene3D	1.10.720.30. 1 hit.
InterPro	IPR001870. B30.2/SPRY. IPR008985. ConA-like_lec_gl_sf. IPR027026. hnRNP_U_like_2. IPR003034. SAP_dom. IPR018355. SPla/RYanodine_receptor_subgr. IPR003877. SPRY_rcpt. [Graphical view]
PANTHER	PTHR12381:SF12. PTHR12381:SF12. 1 hit.
Pfam	PF02037. SAP. 1 hit. PF00622. SPRY. 1 hit. [Graphical view]
SMART	SM00513. SAP. 1 hit. SM00449. SPRY. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS50800. SAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HNRNPUL2. human.
GenomeRNAi	221092.
NextBio	91196.
PMAP-CutDB	Q1KMD3.

Entry information

Entry name

HNRL2_HUMAN

Accession

Primary (citable) accession number: Q1KMD3
Secondary accession number(s): Q8N3B3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	May 30, 2006
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.