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Protein

Heterogeneous nuclear ribonucleoprotein U-like protein 2

Gene

HNRNPUL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein U-like protein 2
Alternative name(s):
Scaffold-attachment factor A2
Short name:
SAF-A2
Gene namesi
Name:HNRNPUL2
Synonyms:HNRPUL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25451. HNRNPUL2.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391554.

Polymorphism and mutation databases

BioMutaiHNRNPUL2.
DMDMi121940728.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Heterogeneous nuclear ribonucleoprotein U-like protein 2PRO_0000278142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei161 – 1611PhosphoserineBy similarity
Modified residuei228 – 2281Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ1KMD3.
PaxDbiQ1KMD3.
PeptideAtlasiQ1KMD3.
PRIDEiQ1KMD3.

PTM databases

PhosphoSiteiQ1KMD3.

Miscellaneous databases

PMAP-CutDBQ1KMD3.

Expressioni

Gene expression databases

BgeeiQ1KMD3.
CleanExiHS_HNRNPUL2.
GenevisibleiQ1KMD3. HS.

Organism-specific databases

HPAiHPA041632.

Interactioni

Subunit structurei

Binds to MLF1 and retains it in the nucleus.By similarity

Protein-protein interaction databases

BioGridi128685. 37 interactions.
IntActiQ1KMD3. 5 interactions.
MINTiMINT-4654781.
STRINGi9606.ENSP00000301785.

Structurei

3D structure databases

ProteinModelPortaliQ1KMD3.
SMRiQ1KMD3. Positions 1-37, 278-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 3735SAPPROSITE-ProRule annotationAdd
BLAST
Domaini226 – 419194B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 241167Glu-richSequence AnalysisAdd
BLAST
Compositional biasi668 – 74679Tyr-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 SAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG297571.
GeneTreeiENSGT00390000020210.
HOGENOMiHOG000253920.
HOVERGENiHBG061101.
InParanoidiQ1KMD3.
OMAiACKAEPR.
OrthoDBiEOG79CZ07.
PhylomeDBiQ1KMD3.
TreeFamiTF317301.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR027417. P-loop_NTPase.
IPR003034. SAP_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50800. SAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1KMD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKRLKVTE LRSELQRRGL DSRGLKVDLA QRLQEALDAE MLEDEAGGGG
60 70 80 90 100
AGPGGACKAE PRPVAASGGG PGGDEEEDEE EEEEDEEALL EDEDEEPPPA
110 120 130 140 150
QALGQAAQPP PEPPEAAAME AAAEPDASEK PAEATAGSGG VNGGEEQGLG
160 170 180 190 200
KREEDEPEER SGDETPGSEV PGDKAAEEQG DDQDSEKSKP AGSDGERRGV
210 220 230 240 250
KRQRDEKDEH GRAYYEFREE AYHSRSKSPL PPEEEAKDEE EDQTLVNLDT
260 270 280 290 300
YTSDLHFQVS KDRYGGQPLF SEKFPTLWSG ARSTYGVTKG KVCFEAKVTQ
310 320 330 340 350
NLPMKEGCTE VSLLRVGWSV DFSRPQLGED EFSYGFDGRG LKAENGQFEE
360 370 380 390 400
FGQTFGENDV IGCFANFETE EVELSFSKNG EDLGVAFWIS KDSLADRALL
410 420 430 440 450
PHVLCKNCVV ELNFGQKEEP FFPPPEEFVF IHAVPVEERV RTAVPPKTIE
460 470 480 490 500
ECEVILMVGL PGSGKTQWAL KYAKENPEKR YNVLGAETVL NQMRMKGLEE
510 520 530 540 550
PEMDPKSRDL LVQQASQCLS KLVQIASRTK RNFILDQCNV YNSGQRRKLL
560 570 580 590 600
LFKTFSRKVV VVVPNEEDWK KRLELRKEVE GDDVPESIML EMKANFSLPE
610 620 630 640 650
KCDYMDEVTY GELEKEEAQP IVTKYKEEAR KLLPPSEKRT NRRNNRNKRN
660 670 680 690 700
RQNRSRGQGY VGGQRRGYDN RAYGQQYWGQ PGNRGGYRNF YDRYRGDYDR
710 720 730 740
FYGRDYEYNR YRDYYRQYNR DWQSYYYHHP QDRDRYYRNY YGYQGYR
Length:747
Mass (Da):85,105
Last modified:May 30, 2006 - v1
Checksum:i7EAAC2F598330AAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ470474 mRNA. Translation: ABF00125.1.
AL834470 mRNA. Translation: CAD39129.2.
CCDSiCCDS41659.1.
RefSeqiNP_001073027.1. NM_001079559.2.
UniGeneiHs.657058.

Genome annotation databases

EnsembliENST00000301785; ENSP00000301785; ENSG00000214753.
GeneIDi221092.
KEGGihsa:221092.
UCSCiuc001nuw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ470474 mRNA. Translation: ABF00125.1.
AL834470 mRNA. Translation: CAD39129.2.
CCDSiCCDS41659.1.
RefSeqiNP_001073027.1. NM_001079559.2.
UniGeneiHs.657058.

3D structure databases

ProteinModelPortaliQ1KMD3.
SMRiQ1KMD3. Positions 1-37, 278-430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128685. 37 interactions.
IntActiQ1KMD3. 5 interactions.
MINTiMINT-4654781.
STRINGi9606.ENSP00000301785.

PTM databases

PhosphoSiteiQ1KMD3.

Polymorphism and mutation databases

BioMutaiHNRNPUL2.
DMDMi121940728.

Proteomic databases

MaxQBiQ1KMD3.
PaxDbiQ1KMD3.
PeptideAtlasiQ1KMD3.
PRIDEiQ1KMD3.

Protocols and materials databases

DNASUi221092.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301785; ENSP00000301785; ENSG00000214753.
GeneIDi221092.
KEGGihsa:221092.
UCSCiuc001nuw.3. human.

Organism-specific databases

CTDi221092.
GeneCardsiGC11M062493.
HGNCiHGNC:25451. HNRNPUL2.
HPAiHPA041632.
neXtProtiNX_Q1KMD3.
PharmGKBiPA162391554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG297571.
GeneTreeiENSGT00390000020210.
HOGENOMiHOG000253920.
HOVERGENiHBG061101.
InParanoidiQ1KMD3.
OMAiACKAEPR.
OrthoDBiEOG79CZ07.
PhylomeDBiQ1KMD3.
TreeFamiTF317301.

Miscellaneous databases

ChiTaRSiHNRNPUL2. human.
GenomeRNAii221092.
NextBioi91196.
PMAP-CutDBQ1KMD3.
PROiQ1KMD3.

Gene expression databases

BgeeiQ1KMD3.
CleanExiHS_HNRNPUL2.
GenevisibleiQ1KMD3. HS.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR027417. P-loop_NTPase.
IPR003034. SAP_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50800. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Scaffold attachment factor A2 (SAF-A2), a mobile isoform of a nucleoskeletal human protein."
    Herrmann F., Fackelmayer F.O.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-747.
    Tissue: Melanoma.
  3. Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 161-174; 213-218; 226-237; 264-282; 298-315; 379-391; 481-494; 497-506; 509-521; 558-570; 594-601; 721-733 AND 739-747, PHOSPHORYLATION AT SER-228, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHNRL2_HUMAN
AccessioniPrimary (citable) accession number: Q1KMD3
Secondary accession number(s): Q8N3B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 30, 2006
Last modified: June 24, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.