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Q1KMD3

- HNRL2_HUMAN

UniProt

Q1KMD3 - HNRL2_HUMAN

Protein

Heterogeneous nuclear ribonucleoprotein U-like protein 2

Gene

HNRNPUL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein U-like protein 2
    Alternative name(s):
    Scaffold-attachment factor A2
    Short name:
    SAF-A2
    Gene namesi
    Name:HNRNPUL2
    Synonyms:HNRPUL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:25451. HNRNPUL2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162391554.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 747747Heterogeneous nuclear ribonucleoprotein U-like protein 2PRO_0000278142Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei161 – 1611PhosphoserineBy similarity
    Modified residuei228 – 2281Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ1KMD3.
    PaxDbiQ1KMD3.
    PeptideAtlasiQ1KMD3.
    PRIDEiQ1KMD3.

    PTM databases

    PhosphoSiteiQ1KMD3.

    Miscellaneous databases

    PMAP-CutDBQ1KMD3.

    Expressioni

    Gene expression databases

    BgeeiQ1KMD3.
    CleanExiHS_HNRNPUL2.
    GenevestigatoriQ1KMD3.

    Organism-specific databases

    HPAiHPA041632.

    Interactioni

    Subunit structurei

    Binds to MLF1 and retains it in the nucleus.By similarity

    Protein-protein interaction databases

    BioGridi128685. 32 interactions.
    IntActiQ1KMD3. 4 interactions.
    MINTiMINT-4654781.
    STRINGi9606.ENSP00000301785.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1KMD3.
    SMRiQ1KMD3. Positions 1-37.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 3735SAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini226 – 419194B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi75 – 241167Glu-richSequence AnalysisAdd
    BLAST
    Compositional biasi668 – 74679Tyr-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 SAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG297571.
    HOGENOMiHOG000253920.
    HOVERGENiHBG061101.
    InParanoidiQ1KMD3.
    OMAiACKAEPR.
    OrthoDBiEOG79CZ07.
    PhylomeDBiQ1KMD3.
    TreeFamiTF317301.

    Family and domain databases

    Gene3Di1.10.720.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR027417. P-loop_NTPase.
    IPR003034. SAP_dom.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF02037. SAP. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view]
    SMARTiSM00513. SAP. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50800. SAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1KMD3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVKRLKVTE LRSELQRRGL DSRGLKVDLA QRLQEALDAE MLEDEAGGGG    50
    AGPGGACKAE PRPVAASGGG PGGDEEEDEE EEEEDEEALL EDEDEEPPPA 100
    QALGQAAQPP PEPPEAAAME AAAEPDASEK PAEATAGSGG VNGGEEQGLG 150
    KREEDEPEER SGDETPGSEV PGDKAAEEQG DDQDSEKSKP AGSDGERRGV 200
    KRQRDEKDEH GRAYYEFREE AYHSRSKSPL PPEEEAKDEE EDQTLVNLDT 250
    YTSDLHFQVS KDRYGGQPLF SEKFPTLWSG ARSTYGVTKG KVCFEAKVTQ 300
    NLPMKEGCTE VSLLRVGWSV DFSRPQLGED EFSYGFDGRG LKAENGQFEE 350
    FGQTFGENDV IGCFANFETE EVELSFSKNG EDLGVAFWIS KDSLADRALL 400
    PHVLCKNCVV ELNFGQKEEP FFPPPEEFVF IHAVPVEERV RTAVPPKTIE 450
    ECEVILMVGL PGSGKTQWAL KYAKENPEKR YNVLGAETVL NQMRMKGLEE 500
    PEMDPKSRDL LVQQASQCLS KLVQIASRTK RNFILDQCNV YNSGQRRKLL 550
    LFKTFSRKVV VVVPNEEDWK KRLELRKEVE GDDVPESIML EMKANFSLPE 600
    KCDYMDEVTY GELEKEEAQP IVTKYKEEAR KLLPPSEKRT NRRNNRNKRN 650
    RQNRSRGQGY VGGQRRGYDN RAYGQQYWGQ PGNRGGYRNF YDRYRGDYDR 700
    FYGRDYEYNR YRDYYRQYNR DWQSYYYHHP QDRDRYYRNY YGYQGYR 747
    Length:747
    Mass (Da):85,105
    Last modified:May 30, 2006 - v1
    Checksum:i7EAAC2F598330AAA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ470474 mRNA. Translation: ABF00125.1.
    AL834470 mRNA. Translation: CAD39129.2.
    CCDSiCCDS41659.1.
    RefSeqiNP_001073027.1. NM_001079559.2.
    UniGeneiHs.657058.

    Genome annotation databases

    EnsembliENST00000301785; ENSP00000301785; ENSG00000214753.
    GeneIDi221092.
    KEGGihsa:221092.
    UCSCiuc001nuw.3. human.

    Polymorphism databases

    DMDMi121940728.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ470474 mRNA. Translation: ABF00125.1 .
    AL834470 mRNA. Translation: CAD39129.2 .
    CCDSi CCDS41659.1.
    RefSeqi NP_001073027.1. NM_001079559.2.
    UniGenei Hs.657058.

    3D structure databases

    ProteinModelPortali Q1KMD3.
    SMRi Q1KMD3. Positions 1-37.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128685. 32 interactions.
    IntActi Q1KMD3. 4 interactions.
    MINTi MINT-4654781.
    STRINGi 9606.ENSP00000301785.

    PTM databases

    PhosphoSitei Q1KMD3.

    Polymorphism databases

    DMDMi 121940728.

    Proteomic databases

    MaxQBi Q1KMD3.
    PaxDbi Q1KMD3.
    PeptideAtlasi Q1KMD3.
    PRIDEi Q1KMD3.

    Protocols and materials databases

    DNASUi 221092.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301785 ; ENSP00000301785 ; ENSG00000214753 .
    GeneIDi 221092.
    KEGGi hsa:221092.
    UCSCi uc001nuw.3. human.

    Organism-specific databases

    CTDi 221092.
    GeneCardsi GC11M062482.
    HGNCi HGNC:25451. HNRNPUL2.
    HPAi HPA041632.
    neXtProti NX_Q1KMD3.
    PharmGKBi PA162391554.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297571.
    HOGENOMi HOG000253920.
    HOVERGENi HBG061101.
    InParanoidi Q1KMD3.
    OMAi ACKAEPR.
    OrthoDBi EOG79CZ07.
    PhylomeDBi Q1KMD3.
    TreeFami TF317301.

    Miscellaneous databases

    ChiTaRSi HNRNPUL2. human.
    GenomeRNAii 221092.
    NextBioi 91196.
    PMAP-CutDB Q1KMD3.
    PROi Q1KMD3.

    Gene expression databases

    Bgeei Q1KMD3.
    CleanExi HS_HNRNPUL2.
    Genevestigatori Q1KMD3.

    Family and domain databases

    Gene3Di 1.10.720.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR027417. P-loop_NTPase.
    IPR003034. SAP_dom.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF02037. SAP. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view ]
    SMARTi SM00513. SAP. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50800. SAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Scaffold attachment factor A2 (SAF-A2), a mobile isoform of a nucleoskeletal human protein."
      Herrmann F., Fackelmayer F.O.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-747.
      Tissue: Melanoma.
    3. Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 161-174; 213-218; 226-237; 264-282; 298-315; 379-391; 481-494; 497-506; 509-521; 558-570; 594-601; 721-733 AND 739-747, PHOSPHORYLATION AT SER-228, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHNRL2_HUMAN
    AccessioniPrimary (citable) accession number: Q1KMD3
    Secondary accession number(s): Q8N3B3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3