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Q1KMD3

- HNRL2_HUMAN

UniProt

Q1KMD3 - HNRL2_HUMAN

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Protein
Heterogeneous nuclear ribonucleoprotein U-like protein 2
Gene
HNRNPUL2, HNRPUL2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein U-like protein 2
Alternative name(s):
Scaffold-attachment factor A2
Short name:
SAF-A2
Gene namesi
Synonyms:HNRPUL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:25451. HNRNPUL2.

Subcellular locationi

Nucleus By similarity By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Heterogeneous nuclear ribonucleoprotein U-like protein 2
PRO_0000278142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei161 – 1611Phosphoserine By similarity1 Publication
Modified residuei228 – 2281Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ1KMD3.
PaxDbiQ1KMD3.
PeptideAtlasiQ1KMD3.
PRIDEiQ1KMD3.

PTM databases

PhosphoSiteiQ1KMD3.

Miscellaneous databases

PMAP-CutDBQ1KMD3.

Expressioni

Gene expression databases

BgeeiQ1KMD3.
CleanExiHS_HNRNPUL2.
GenevestigatoriQ1KMD3.

Organism-specific databases

HPAiHPA041632.

Interactioni

Subunit structurei

Binds to MLF1 and retains it in the nucleus By similarity.By similarity

Protein-protein interaction databases

BioGridi128685. 32 interactions.
IntActiQ1KMD3. 4 interactions.
MINTiMINT-4654781.
STRINGi9606.ENSP00000301785.

Structurei

3D structure databases

ProteinModelPortaliQ1KMD3.
SMRiQ1KMD3. Positions 1-37.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 3735SAP
Add
BLAST
Domaini226 – 419194B30.2/SPRY
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 241167Glu-rich
Add
BLAST
Compositional biasi668 – 74679Tyr-rich
Add
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.
Contains 1 SAP domain.

Phylogenomic databases

eggNOGiNOG297571.
HOGENOMiHOG000253920.
HOVERGENiHBG061101.
InParanoidiQ1KMD3.
OMAiACKAEPR.
OrthoDBiEOG79CZ07.
PhylomeDBiQ1KMD3.
TreeFamiTF317301.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR027417. P-loop_NTPase.
IPR003034. SAP_dom.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50800. SAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1KMD3-1 [UniParc]FASTAAdd to Basket

« Hide

MEVKRLKVTE LRSELQRRGL DSRGLKVDLA QRLQEALDAE MLEDEAGGGG    50
AGPGGACKAE PRPVAASGGG PGGDEEEDEE EEEEDEEALL EDEDEEPPPA 100
QALGQAAQPP PEPPEAAAME AAAEPDASEK PAEATAGSGG VNGGEEQGLG 150
KREEDEPEER SGDETPGSEV PGDKAAEEQG DDQDSEKSKP AGSDGERRGV 200
KRQRDEKDEH GRAYYEFREE AYHSRSKSPL PPEEEAKDEE EDQTLVNLDT 250
YTSDLHFQVS KDRYGGQPLF SEKFPTLWSG ARSTYGVTKG KVCFEAKVTQ 300
NLPMKEGCTE VSLLRVGWSV DFSRPQLGED EFSYGFDGRG LKAENGQFEE 350
FGQTFGENDV IGCFANFETE EVELSFSKNG EDLGVAFWIS KDSLADRALL 400
PHVLCKNCVV ELNFGQKEEP FFPPPEEFVF IHAVPVEERV RTAVPPKTIE 450
ECEVILMVGL PGSGKTQWAL KYAKENPEKR YNVLGAETVL NQMRMKGLEE 500
PEMDPKSRDL LVQQASQCLS KLVQIASRTK RNFILDQCNV YNSGQRRKLL 550
LFKTFSRKVV VVVPNEEDWK KRLELRKEVE GDDVPESIML EMKANFSLPE 600
KCDYMDEVTY GELEKEEAQP IVTKYKEEAR KLLPPSEKRT NRRNNRNKRN 650
RQNRSRGQGY VGGQRRGYDN RAYGQQYWGQ PGNRGGYRNF YDRYRGDYDR 700
FYGRDYEYNR YRDYYRQYNR DWQSYYYHHP QDRDRYYRNY YGYQGYR 747
Length:747
Mass (Da):85,105
Last modified:May 30, 2006 - v1
Checksum:i7EAAC2F598330AAA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ470474 mRNA. Translation: ABF00125.1.
AL834470 mRNA. Translation: CAD39129.2.
CCDSiCCDS41659.1.
RefSeqiNP_001073027.1. NM_001079559.2.
UniGeneiHs.657058.

Genome annotation databases

EnsembliENST00000301785; ENSP00000301785; ENSG00000214753.
GeneIDi221092.
KEGGihsa:221092.
UCSCiuc001nuw.3. human.

Polymorphism databases

DMDMi121940728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ470474 mRNA. Translation: ABF00125.1 .
AL834470 mRNA. Translation: CAD39129.2 .
CCDSi CCDS41659.1.
RefSeqi NP_001073027.1. NM_001079559.2.
UniGenei Hs.657058.

3D structure databases

ProteinModelPortali Q1KMD3.
SMRi Q1KMD3. Positions 1-37.
ModBasei Search...

Protein-protein interaction databases

BioGridi 128685. 32 interactions.
IntActi Q1KMD3. 4 interactions.
MINTi MINT-4654781.
STRINGi 9606.ENSP00000301785.

PTM databases

PhosphoSitei Q1KMD3.

Polymorphism databases

DMDMi 121940728.

Proteomic databases

MaxQBi Q1KMD3.
PaxDbi Q1KMD3.
PeptideAtlasi Q1KMD3.
PRIDEi Q1KMD3.

Protocols and materials databases

DNASUi 221092.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301785 ; ENSP00000301785 ; ENSG00000214753 .
GeneIDi 221092.
KEGGi hsa:221092.
UCSCi uc001nuw.3. human.

Organism-specific databases

CTDi 221092.
GeneCardsi GC11M062482.
HGNCi HGNC:25451. HNRNPUL2.
HPAi HPA041632.
neXtProti NX_Q1KMD3.
PharmGKBi PA162391554.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297571.
HOGENOMi HOG000253920.
HOVERGENi HBG061101.
InParanoidi Q1KMD3.
OMAi ACKAEPR.
OrthoDBi EOG79CZ07.
PhylomeDBi Q1KMD3.
TreeFami TF317301.

Miscellaneous databases

ChiTaRSi HNRNPUL2. human.
GenomeRNAii 221092.
NextBioi 91196.
PMAP-CutDB Q1KMD3.
PROi Q1KMD3.

Gene expression databases

Bgeei Q1KMD3.
CleanExi HS_HNRNPUL2.
Genevestigatori Q1KMD3.

Family and domain databases

Gene3Di 1.10.720.30. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR027417. P-loop_NTPase.
IPR003034. SAP_dom.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view ]
Pfami PF02037. SAP. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view ]
SMARTi SM00513. SAP. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50800. SAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Scaffold attachment factor A2 (SAF-A2), a mobile isoform of a nucleoskeletal human protein."
    Herrmann F., Fackelmayer F.O.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-747.
    Tissue: Melanoma.
  3. Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 161-174; 213-218; 226-237; 264-282; 298-315; 379-391; 481-494; 497-506; 509-521; 558-570; 594-601; 721-733 AND 739-747, PHOSPHORYLATION AT SER-228, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHNRL2_HUMAN
AccessioniPrimary (citable) accession number: Q1KMD3
Secondary accession number(s): Q8N3B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 30, 2006
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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