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Protein

Heterogeneous nuclear ribonucleoprotein U-like protein 2

Gene

HNRNPUL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein U-like protein 2
Alternative name(s):
Scaffold-attachment factor A2
Short name:
SAF-A2
Gene namesi
Name:HNRNPUL2
Synonyms:HNRPUL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000214753.2
HGNCiHGNC:25451 HNRNPUL2
neXtProtiNX_Q1KMD3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214753
PharmGKBiPA162391554

Polymorphism and mutation databases

BioMutaiHNRNPUL2
DMDMi121940728

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002781421 – 747Heterogeneous nuclear ribonucleoprotein U-like protein 2Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161PhosphoserineBy similarity1
Modified residuei165PhosphothreonineBy similarity1
Modified residuei168PhosphoserineBy similarity1
Modified residuei185PhosphoserineBy similarity1
Modified residuei188PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei228Phosphoserine1 Publication1
Modified residuei656Omega-N-methylarginineBy similarity1
Modified residuei684Omega-N-methylarginineBy similarity1
Modified residuei738Omega-N-methylarginineCombined sources1
Modified residuei747Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ1KMD3
MaxQBiQ1KMD3
PaxDbiQ1KMD3
PeptideAtlasiQ1KMD3
PRIDEiQ1KMD3

PTM databases

iPTMnetiQ1KMD3
PhosphoSitePlusiQ1KMD3
SwissPalmiQ1KMD3

Miscellaneous databases

PMAP-CutDBQ1KMD3

Expressioni

Gene expression databases

BgeeiENSG00000214753
CleanExiHS_HNRNPUL2
GenevisibleiQ1KMD3 HS

Organism-specific databases

HPAiHPA041632
HPA056696
HPA067699

Interactioni

Subunit structurei

Binds to MLF1 and retains it in the nucleus.By similarity

Protein-protein interaction databases

BioGridi128685, 68 interactors
IntActiQ1KMD3, 24 interactors
MINTiQ1KMD3
STRINGi9606.ENSP00000301785

Structurei

3D structure databases

ProteinModelPortaliQ1KMD3
SMRiQ1KMD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 37SAPPROSITE-ProRule annotationAdd BLAST35
Domaini226 – 419B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 241Glu-richSequence analysisAdd BLAST167
Compositional biasi668 – 746Tyr-richSequence analysisAdd BLAST79

Phylogenomic databases

eggNOGiENOG410IR1X Eukaryota
ENOG41101YN LUCA
GeneTreeiENSGT00390000020210
HOGENOMiHOG000253920
HOVERGENiHBG061101
InParanoidiQ1KMD3
OMAiACKAEPR
OrthoDBiEOG091G041T
PhylomeDBiQ1KMD3
TreeFamiTF317301

Family and domain databases

CDDicd12884 SPRY_hnRNP, 1 hit
Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR027417 P-loop_NTPase
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR003877 SPRY_dom
IPR035778 SPRY_hnRNP_U
PfamiView protein in Pfam
PF02037 SAP, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 1 hit
SSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50800 SAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q1KMD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKRLKVTE LRSELQRRGL DSRGLKVDLA QRLQEALDAE MLEDEAGGGG
60 70 80 90 100
AGPGGACKAE PRPVAASGGG PGGDEEEDEE EEEEDEEALL EDEDEEPPPA
110 120 130 140 150
QALGQAAQPP PEPPEAAAME AAAEPDASEK PAEATAGSGG VNGGEEQGLG
160 170 180 190 200
KREEDEPEER SGDETPGSEV PGDKAAEEQG DDQDSEKSKP AGSDGERRGV
210 220 230 240 250
KRQRDEKDEH GRAYYEFREE AYHSRSKSPL PPEEEAKDEE EDQTLVNLDT
260 270 280 290 300
YTSDLHFQVS KDRYGGQPLF SEKFPTLWSG ARSTYGVTKG KVCFEAKVTQ
310 320 330 340 350
NLPMKEGCTE VSLLRVGWSV DFSRPQLGED EFSYGFDGRG LKAENGQFEE
360 370 380 390 400
FGQTFGENDV IGCFANFETE EVELSFSKNG EDLGVAFWIS KDSLADRALL
410 420 430 440 450
PHVLCKNCVV ELNFGQKEEP FFPPPEEFVF IHAVPVEERV RTAVPPKTIE
460 470 480 490 500
ECEVILMVGL PGSGKTQWAL KYAKENPEKR YNVLGAETVL NQMRMKGLEE
510 520 530 540 550
PEMDPKSRDL LVQQASQCLS KLVQIASRTK RNFILDQCNV YNSGQRRKLL
560 570 580 590 600
LFKTFSRKVV VVVPNEEDWK KRLELRKEVE GDDVPESIML EMKANFSLPE
610 620 630 640 650
KCDYMDEVTY GELEKEEAQP IVTKYKEEAR KLLPPSEKRT NRRNNRNKRN
660 670 680 690 700
RQNRSRGQGY VGGQRRGYDN RAYGQQYWGQ PGNRGGYRNF YDRYRGDYDR
710 720 730 740
FYGRDYEYNR YRDYYRQYNR DWQSYYYHHP QDRDRYYRNY YGYQGYR
Length:747
Mass (Da):85,105
Last modified:May 30, 2006 - v1
Checksum:i7EAAC2F598330AAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ470474 mRNA Translation: ABF00125.1
AL834470 mRNA Translation: CAD39129.2
CCDSiCCDS41659.1
RefSeqiNP_001073027.1, NM_001079559.2
UniGeneiHs.657058

Genome annotation databases

EnsembliENST00000301785; ENSP00000301785; ENSG00000214753
GeneIDi221092
KEGGihsa:221092
UCSCiuc001nuw.4 human

Similar proteinsi

Entry informationi

Entry nameiHNRL2_HUMAN
AccessioniPrimary (citable) accession number: Q1KMD3
Secondary accession number(s): Q8N3B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 30, 2006
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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