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Protein

Cathelicidin antimicrobial peptide

Gene

CAMP

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelicidin antimicrobial peptideBy similarity
Cleaved into the following 2 chains:
Antibacterial peptide FALL-39By similarity
Alternative name(s):
FALL-39 peptide antibioticBy similarity
Antibacterial peptide LL-37By similarity
Gene namesi
Name:CAMPBy similarity
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Propeptidei31 – 131101By similarityPRO_0000251776Add
BLAST
Peptidei132 – 17039Antibacterial peptide FALL-39PRO_0000251777Add
BLAST
Peptidei134 – 17037Antibacterial peptide LL-37PRO_0000251778Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ1KLX1.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000025671.

Structurei

3D structure databases

ProteinModelPortaliQ1KLX1.
SMRiQ1KLX1. Positions 31-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiQ1KLX1.
KOiK13916.
OMAiCDFKKDG.
OrthoDBiEOG793B9Q.
TreeFamiTF338457.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
[Graphical view]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1KLX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTQRDGHSL GRWSLVLLLL GLVMPLAIVA QVLSYKEAVL RAIDGINQRS
60 70 80 90 100
SDANLYRLLD LDPRPTMDGD PDTPKPVSFT VKETVCPRTT QQSPEDCDFK
110 120 130 140 150
KDGLVKRCMG TVTLNQARGS FDISCDKDNK RFALLGDFFR KSKEKIGKEF
160 170
KRIVQRIKDF LRNLVPRTES
Length:170
Mass (Da):19,287
Last modified:May 30, 2006 - v1
Checksum:iE98B07CAC584B2DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ471371 Genomic DNA. Translation: ABE96635.1.
RefSeqiNP_001065283.1. NM_001071815.1.
UniGeneiPtr.6338.

Genome annotation databases

EnsembliENSPTRT00000027834; ENSPTRP00000025671; ENSPTRG00000014880.
GeneIDi741881.
KEGGiptr:741881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ471371 Genomic DNA. Translation: ABE96635.1.
RefSeqiNP_001065283.1. NM_001071815.1.
UniGeneiPtr.6338.

3D structure databases

ProteinModelPortaliQ1KLX1.
SMRiQ1KLX1. Positions 31-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000025671.

Proteomic databases

PaxDbiQ1KLX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000027834; ENSPTRP00000025671; ENSPTRG00000014880.
GeneIDi741881.
KEGGiptr:741881.

Organism-specific databases

CTDi820.

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiQ1KLX1.
KOiK13916.
OMAiCDFKKDG.
OrthoDBiEOG793B9Q.
TreeFamiTF338457.

Miscellaneous databases

NextBioi20908978.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
[Graphical view]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity."
    Zelezetsky I., Pontillo A., Puzzi L., Antcheva N., Segat L., Pacor S., Crovella S., Tossi A.
    J. Biol. Chem. 281:19861-19871(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCAMP_PANTR
AccessioniPrimary (citable) accession number: Q1KLX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 30, 2006
Last modified: May 11, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.