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Protein

Cathelicidin antimicrobial peptide

Gene

CAMP

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.By similarity

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelicidin antimicrobial peptideBy similarity
Cleaved into the following 2 chains:
Antibacterial peptide FALL-39By similarity
Alternative name(s):
FALL-39 peptide antibioticBy similarity
Antibacterial peptide LL-37By similarity
Gene namesi
Name:CAMPBy similarity
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
PropeptideiPRO_000025177631 – 131By similarityAdd BLAST101
PeptideiPRO_0000251777132 – 170Antibacterial peptide FALL-39Add BLAST39
PeptideiPRO_0000251778134 – 170Antibacterial peptide LL-37Add BLAST37

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ1KLX1.
PRIDEiQ1KLX1.

Expressioni

Gene expression databases

BgeeiENSPTRG00000014880.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000025671.

Structurei

3D structure databases

ProteinModelPortaliQ1KLX1.
SMRiQ1KLX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiQ1KLX1.
KOiK13916.
OMAiTVCPKTT.
OrthoDBiEOG091G0X95.
TreeFamiTF338457.

Family and domain databases

InterProiView protein in InterPro
IPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiView protein in Pfam
PF12153. CAP18_C. 1 hit.
PROSITEiView protein in PROSITE
PS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1KLX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTQRDGHSL GRWSLVLLLL GLVMPLAIVA QVLSYKEAVL RAIDGINQRS
60 70 80 90 100
SDANLYRLLD LDPRPTMDGD PDTPKPVSFT VKETVCPRTT QQSPEDCDFK
110 120 130 140 150
KDGLVKRCMG TVTLNQARGS FDISCDKDNK RFALLGDFFR KSKEKIGKEF
160 170
KRIVQRIKDF LRNLVPRTES
Length:170
Mass (Da):19,287
Last modified:May 30, 2006 - v1
Checksum:iE98B07CAC584B2DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ471371 Genomic DNA. Translation: ABE96635.1.
RefSeqiNP_001065283.1. NM_001071815.1.
UniGeneiPtr.6338.

Genome annotation databases

EnsembliENSPTRT00000027834; ENSPTRP00000025671; ENSPTRG00000014880.
GeneIDi741881.
KEGGiptr:741881.

Similar proteinsi

Entry informationi

Entry nameiCAMP_PANTR
AccessioniPrimary (citable) accession number: Q1KLX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 30, 2006
Last modified: August 30, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families