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Q1KL14 (HXA5A_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Homeobox protein Hox-A5a
PRO_0000265967

Regions

DNA binding198 – 25760Homeobox
Motif180 – 1856Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
Q1KL14 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 9C898A7161913F1E

FASTA27430,717
        10         20         30         40         50         60 
MSSYFVNSFC GRYPNGADFQ LHNYGDHDTA DEQYRNSTTM HSTRYGYGYN GMDLTVGRDG 

        70         80         90        100        110        120 
TGHFVGNERT RGYSENHSAT AASVESVRYN QTTNTTGTSS LSPPPDPLPC SSVSSASPVT 

       130        140        150        160        170        180 
ETQPQHRVVK NSVTTPCSSS SGGTLLVNRD CASKSSPLEE EKPAGGATPQ NVNDSTQPQI 

       190        200        210        220        230        240 
YPWMRKIHIS HELSGPEGKR ARTAYTRYQT LELEKEFHFN RYLTRRRRIE IAHALCLSER 

       250        260        270 
QIKIWFQNRR MKWKKDNKLK SMNMASAGGG VYRP 

« Hide

References

[1]"Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ481663 Genomic DNA. Translation: ABF22380.1.

3D structure databases

ProteinModelPortalQ1KL14.
SMRQ1KL14. Positions 178-258.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING31033.ENSTRUP00000046718.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSTRUT00000046876; ENSTRUP00000046718; ENSTRUG00000018252.

Phylogenomic databases

eggNOGNOG236516.
GeneTreeENSGT00750000117269.
InParanoidQ1KL14.
OMASVSEQYR.
OrthoDBEOG780RP4.
TreeFamTF316310.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXA5A_TAKRU
AccessionPrimary (citable) accession number: Q1KL14
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries