Reviewed, UniProtKB/Swiss-Prot Q1KL14 (HXA5A_TAKRU)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A5a

Gene names

Name:

hoxa5a

Organism

Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Homeobox protein Hox-A5a		PRO_0000265967
Regions
	DNA binding	198 – 257	60	Homeobox
	Motif	180 – 185	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q1KL14-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 9C898A7161913F1E	FASTA	274	30,717
	10 20 30 40 50 60 MSSYFVNSFC GRYPNGADFQ LHNYGDHDTA DEQYRNSTTM HSTRYGYGYN GMDLTVGRDG 70 80 90 100 110 120 TGHFVGNERT RGYSENHSAT AASVESVRYN QTTNTTGTSS LSPPPDPLPC SSVSSASPVT 130 140 150 160 170 180 ETQPQHRVVK NSVTTPCSSS SGGTLLVNRD CASKSSPLEE EKPAGGATPQ NVNDSTQPQI 190 200 210 220 230 240 YPWMRKIHIS HELSGPEGKR ARTAYTRYQT LELEKEFHFN RYLTRRRRIE IAHALCLSER 250 260 270 QIKIWFQNRR MKWKKDNKLK SMNMASAGGG VYRP

References

[1]

"Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters." Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B. Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed: 16636282] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ481663 Genomic DNA. Translation: ABF22380.1.
3D structure databases
SMR	Q1KL14. Positions 199-260.
ModBase	Search...
Genome annotation databases
Ensembl	ENSTRUT00000046876; ENSTRUP00000046718; ENSTRUG00000018252; Takifugu rubripes. [Genome view]
Phylogenomic databases
HOVERGEN	Q1KL14.
OrthoDB	EOG9PCDB9
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA5A_TAKRU

Accession

Primary (citable) accession number: Q1KL14

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	May 30, 2006
Last modified:	November 24, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)