Q1KL13 (HXA4A_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A4a

Gene names

Name:

hoxa4a

Organism

Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Homeobox protein Hox-A4a		PRO_0000265966
Regions
	DNA binding	149 – 208	60	Homeobox
	Motif	128 – 133	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q1KL13 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: BB601681485DD03F	FASTA	255	28,699
	10 20 30 40 50 60 MTMSSYLINS NYIEPSFPPC DEYQQSGYIP NHGDYYERPK DTGFPHHSEP SYPRSNYTES 70 80 90 100 110 120 GYDYGNVPTT GLEDFNDGHH AQPQPVPQSH GPRLSAAPDG GAGAIASKDC SIASEVYPGV 130 140 150 160 170 180 AKGKEPVVYP WMKKVHATNI TAGYNGGVPK RSRTAYTRQQ ALELEKEFHF NRYLTRRRRV 190 200 210 220 230 240 EIAHTMCLSE RQVKIWFQNR RMKWKKEHKL PNTKIRSSSS ASSSASGAQQ HQQQQQQLQI 250 KSGQQLVPTP SAVSL

References

[1]

"Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters." Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B. Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed: 16636282] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ481663 Genomic DNA. Translation: ABF22381.1.
3D structure databases
ProteinModelPortal	Q1KL13.
SMR	Q1KL13. Positions 122-209.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1KL13.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	fiNOG06757.
PhylomeDB	Q1KL13.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA4A_TAKRU

Accession

Primary (citable) accession number: Q1KL13

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	May 30, 2006
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program